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P45213 (MSRAB_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Peptide methionine sulfoxide reductase MsrA/MsrB

Including the following 2 domains:

  1. Peptide methionine sulfoxide reductase MsrA
    Short name=Protein-methionine-S-oxide reductase
    EC=1.8.4.11
    Alternative name(s):
    Peptide-methionine (S)-S-oxide reductase
    Short name=Peptide Met(O) reductase
  2. Peptide methionine sulfoxide reductase MsrB
    EC=1.8.4.12
    Alternative name(s):
    Peptide-methionine (R)-S-oxide reductase
Gene names
Name:msrAB
Ordered Locus Names:HI_1455
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length353 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP MF_01400

Catalytic activity

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01400

L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01400

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin.

Sequence similarities

In the N-terminal section; belongs to the MsrA Met sulfoxide reductase family.

In the C-terminal section; belongs to the MsrB Met sulfoxide reductase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 353353Peptide methionine sulfoxide reductase MsrA/MsrB HAMAP MF_01400
PRO_0000138513

Regions

Region43 – 196154Peptide methionine sulfoxide reductase A HAMAP MF_01400
Region213 – 336124Peptide methionine sulfoxide reductase B HAMAP MF_01400

Sites

Active site511 By similarity
Active site3251 By similarity

Sequences

Sequence LengthMass (Da)Tools
P45213 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: ADBCDDB4D90A8B1E

FASTA35339,864
        10         20         30         40         50         60 
MKLSKTFLFI TALCCATPTL AIQNSTSSSG EQKMAMENTQ NIREIYLAGG CFWGMEAYME 

        70         80         90        100        110        120 
RIHGVKDAIS GYANGNTEKT SYQMIGLTDH AETVKVTYDA NQISLDKLLK YYFKVIDPTS 

       130        140        150        160        170        180 
VNKQGNDRGR QYRTGIYYQD GADKAVIGQA LAQLQTKYKK PVQIEVQPLK NYIVAEEYHQ 

       190        200        210        220        230        240 
DYLKKNPNGY CHIDITKADE PVIDEKDYPK PSDAELKAKL TPLQYSVTQN KHTERSFSNE 

       250        260        270        280        290        300 
YWDNFQPGIY VDITTGEPVF SSNDKFESGC GWPSFTKPII KDVVHYETDN SFNMQRTEVL 

       310        320        330        340        350 
SRAGNAHLGH VFDDGPKDKG GLRYCINSAS IKFIPLAEME KAGYGYLIQS IKK

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L42023 Genomic DNA. Translation: AAC23103.1.
PIRE64124.
RefSeqNP_439606.1. NC_000907.1.

3D structure databases

ProteinModelPortalP45213.
SMRP45213. Positions 41-202, 208-347.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID950358.
GenomeReviewsGene locus HI_1455 in contig L42023_GR.
KEGGhin:HI1455.
NMPDRfig|71421.1.peg.1388.
PATRIC20191613. VBIHaeInf48452_1516.
TIGRHI_1455.

Phylogenomic databases

HOGENOMHBG715255.
OMAGIYYTDK.
PhylomeDBP45213.
ProtClustDBCLSK808528.

Enzyme and pathway databases

BioCycHINF71421:HI_1455-MONOMER.

Family and domain databases

HAMAPMF_01400. MsrB. Fused.
[Tree]
MF_01401. MsrA. Fused.
[Tree]
InterProIPR002579. Methionine_sulphoxide_MsrB.
IPR011057. Mss4-like.
IPR002569. Peptide_Met_Sox_Rdtase_MsrA.
[Graphical view]
Gene3DG3DSA:3.30.1060.10. MsrA. 1 hit.
G3DSA:2.170.150.20. MsrB. 1 hit.
KOK12267.
PfamPF01625. PMSR. 1 hit.
PF01641. SelR. 1 hit.
[Graphical view]
SUPFAMSSF55068. MsrA. 1 hit.
SSF51316. Mss4_like. 1 hit.
TIGRFAMsTIGR00401. MsrA. 1 hit.
TIGR00357. TIGR00357. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMSRAB_HAEIN
AccessionPrimary (citable) accession number: P45213
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: January 25, 2012
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names

SIMILARITY comments

Index of protein domains and families

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