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P45208 (METF_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
5,10-methylenetetrahydrofolate reductase

EC=1.5.1.20
Gene names
Name:metF
Ordered Locus Names:HI_1444
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length292 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H.

Cofactor

FAD By similarity.

Pathway

One-carbon metabolism; tetrahydrofolate interconversion.

Sequence similarities

Belongs to the methylenetetrahydrofolate reductase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2922925,10-methylenetetrahydrofolate reductase
PRO_0000190263

Regions

Nucleotide binding26 – 316NAD By similarity
Nucleotide binding57 – 604FAD By similarity
Nucleotide binding57 – 582NAD By similarity
Nucleotide binding116 – 1183FAD By similarity
Nucleotide binding129 – 1302FAD By similarity
Nucleotide binding154 – 1574FAD By similarity
Nucleotide binding163 – 1708FAD By similarity

Sites

Active site261Proton donor/acceptor By similarity
Binding site861FAD By similarity
Binding site1181Substrate By similarity
Binding site1501FAD By similarity
Binding site1811Substrate By similarity
Binding site2171Substrate By similarity
Binding site2731Substrate By similarity
Binding site2771Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P45208 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: C6DCC9BC80CFF9B4

FASTA29233,020
        10         20         30         40         50         60 
MSYAKEIDTL NQHIADFNKK INVSFEFFPP KNEKMETLLW DSIHRLKVLK PKFVSVTYGA 

        70         80         90        100        110        120 
NSGERDRTHG IVKAIKQETG LEAAPHLTGI DATPEELKQI ARDYWDSGIR RIVALRGDEP 

       130        140        150        160        170        180 
KGYAKKPFYA SDLVELLRSV ADFDISVAAY PEVHPEAKSA QADLINLKRK IDAGANHVIT 

       190        200        210        220        230        240 
QFFFDIENYL RFRDRCASIG IDTEIVPGIL PVTNFKQLQK MASFTNVKIP AWLVKAYDGL 

       250        260        270        280        290 
DNDPTTRNLV AASVAMDMVK ILSREGVNDF HFYTLNRSEL TYAICHMLGV RP 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC23094.1.
PIRH64123.
RefSeqNP_439596.1. NC_000907.1.

3D structure databases

ProteinModelPortalP45208.
SMRP45208. Positions 3-292.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI1444.

Proteomic databases

PRIDEP45208.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC23094; AAC23094; HI_1444.
GeneID950344.
KEGGhin:HI1444.
PATRIC20191593. VBIHaeInf48452_1506.

Phylogenomic databases

eggNOGCOG0685.
KOK00297.
OMAFIRAETG.
OrthoDBEOG6D2KVW.
ProtClustDBPRK09432.

Enzyme and pathway databases

UniPathwayUPA00193.

Family and domain databases

InterProIPR003171. Mehydrof_redctse.
IPR004620. MTHF_reductase_bac.
[Graphical view]
PfamPF02219. MTHFR. 1 hit.
[Graphical view]
TIGRFAMsTIGR00676. fadh2. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMETF_HAEIN
AccessionPrimary (citable) accession number: P45208
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: December 11, 2013
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names