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Protein

Stringent starvation protein B homolog

Gene

sspB

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enhances recognition of ssrA-tagged proteins by the ClpX-ClpP protease; the ssrA degradation tag (AANDENYALAA) is added trans-translationally to proteins that are stalled on the ribosome, freeing the ribosome and targeting stalled peptides for degradation. SspB activates the ATPase activity of ClpX. Seems to act in concert with SspA in the regulation of several proteins during exponential and stationary-phase growth (By similarity).By similarity
Also stimulates degradation of the N-terminus of RseA (residues 1-108, alone or in complex with sigma-E) by ClpX-ClpP in a non-ssrA-mediated fashion.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Stringent starvation protein B homolog
Alternative name(s):
Adapter protein SspB
Specificity-enhancing factor SspB
Gene namesi
Name:sspB
Ordered Locus Names:HI_1440
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000722201 – 150Stringent starvation protein B homologAdd BLAST150

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi71421.HI1440.

Structurei

Secondary structure

1150
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi9 – 22Combined sources14
Beta strandi27 – 32Combined sources6
Beta strandi33 – 35Combined sources3
Helixi42 – 44Combined sources3
Beta strandi46 – 48Combined sources3
Beta strandi49 – 53Combined sources5
Turni56 – 58Combined sources3
Beta strandi60 – 64Combined sources5
Beta strandi66 – 75Combined sources10
Beta strandi78 – 85Combined sources8
Helixi86 – 88Combined sources3
Beta strandi89 – 94Combined sources6
Turni95 – 97Combined sources3
Beta strandi100 – 102Combined sources3
Helixi107 – 109Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OU8X-ray1.60A/B1-111[»]
1OU9X-ray1.80A/B/C1-129[»]
1OULX-ray2.20A/B1-129[»]
1TWBX-ray1.90A/B1-110[»]
1ZSZX-ray2.00A1-110[»]
B1-111[»]
C1-129[»]
ProteinModelPortaliP45206.
SMRiP45206.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP45206.

Family & Domainsi

Sequence similaritiesi

Belongs to the SspB family.Curated

Phylogenomic databases

eggNOGiENOG4105KB2. Bacteria.
COG2969. LUCA.
KOiK03600.
OMAiNDFISFT.
PhylomeDBiP45206.

Family and domain databases

Gene3Di2.30.30.220. 1 hit.
InterProiIPR007481. SspB.
[Graphical view]
PfamiPF04386. SspB. 1 hit.
[Graphical view]
PIRSFiPIRSF005276. SspB. 1 hit.
SUPFAMiSSF101738. SSF101738. 1 hit.

Sequencei

Sequence statusi: Complete.

P45206-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYKSSPKRP YLLRAYYDWL VDNSFTPYLV VDATYLGVNV PVEYVKDGQI
60 70 80 90 100
VLNLSASATG NLQLTNDFIQ FNARFKGVSR ELYIPMGAAL AIYARENGDG
110 120 130 140 150
VMFEPEEIYD ELNIEPDTEQ PTGFYEAVDK PKKREEKKKT KSVSHLRIVD
Length:150
Mass (Da):17,168
Last modified:November 1, 1995 - v1
Checksum:iE8A2E3BD550732A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC23089.1.
PIRiD64123.
RefSeqiNP_439592.1. NC_000907.1.
WP_005650453.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC23089; AAC23089; HI_1440.
GeneIDi950343.
KEGGihin:HI1440.
PATRICi20191585. VBIHaeInf48452_1502.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC23089.1.
PIRiD64123.
RefSeqiNP_439592.1. NC_000907.1.
WP_005650453.1. NC_000907.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OU8X-ray1.60A/B1-111[»]
1OU9X-ray1.80A/B/C1-129[»]
1OULX-ray2.20A/B1-129[»]
1TWBX-ray1.90A/B1-110[»]
1ZSZX-ray2.00A1-110[»]
B1-111[»]
C1-129[»]
ProteinModelPortaliP45206.
SMRiP45206.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI1440.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC23089; AAC23089; HI_1440.
GeneIDi950343.
KEGGihin:HI1440.
PATRICi20191585. VBIHaeInf48452_1502.

Phylogenomic databases

eggNOGiENOG4105KB2. Bacteria.
COG2969. LUCA.
KOiK03600.
OMAiNDFISFT.
PhylomeDBiP45206.

Miscellaneous databases

EvolutionaryTraceiP45206.

Family and domain databases

Gene3Di2.30.30.220. 1 hit.
InterProiIPR007481. SspB.
[Graphical view]
PfamiPF04386. SspB. 1 hit.
[Graphical view]
PIRSFiPIRSF005276. SspB. 1 hit.
SUPFAMiSSF101738. SSF101738. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSSPB_HAEIN
AccessioniPrimary (citable) accession number: P45206
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.