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Protein

Stringent starvation protein B homolog

Gene

sspB

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enhances recognition of ssrA-tagged proteins by the ClpX-ClpP protease; the ssrA degradation tag (AANDENYALAA) is added trans-translationally to proteins that are stalled on the ribosome, freeing the ribosome and targeting stalled peptides for degradation. SspB activates the ATPase activity of ClpX. Seems to act in concert with SspA in the regulation of several proteins during exponential and stationary-phase growth (By similarity).By similarity
Also stimulates degradation of the N-terminus of RseA (residues 1-108, alone or in complex with sigma-E) by ClpX-ClpP in a non-ssrA-mediated fashion.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Stringent starvation protein B homolog
Alternative name(s):
Adapter protein SspB
Specificity-enhancing factor SspB
Gene namesi
Name:sspB
Ordered Locus Names:HI_1440
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 150150Stringent starvation protein B homologPRO_0000072220Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi71421.HI1440.

Structurei

Secondary structure

1
150
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi9 – 2214Combined sources
Beta strandi27 – 326Combined sources
Beta strandi33 – 353Combined sources
Helixi42 – 443Combined sources
Beta strandi46 – 483Combined sources
Beta strandi49 – 535Combined sources
Turni56 – 583Combined sources
Beta strandi60 – 645Combined sources
Beta strandi66 – 7510Combined sources
Beta strandi78 – 858Combined sources
Helixi86 – 883Combined sources
Beta strandi89 – 946Combined sources
Turni95 – 973Combined sources
Beta strandi100 – 1023Combined sources
Helixi107 – 1093Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OU8X-ray1.60A/B1-111[»]
1OU9X-ray1.80A/B/C1-129[»]
1OULX-ray2.20A/B1-129[»]
1TWBX-ray1.90A/B1-110[»]
1ZSZX-ray2.00A1-110[»]
B1-111[»]
C1-129[»]
ProteinModelPortaliP45206.
SMRiP45206. Positions 1-122.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP45206.

Family & Domainsi

Sequence similaritiesi

Belongs to the SspB family.Curated

Phylogenomic databases

eggNOGiENOG4105KB2. Bacteria.
COG2969. LUCA.
KOiK03600.
OMAiNDFISFT.
PhylomeDBiP45206.

Family and domain databases

Gene3Di2.30.30.220. 1 hit.
InterProiIPR007481. SspB.
[Graphical view]
PfamiPF04386. SspB. 1 hit.
[Graphical view]
PIRSFiPIRSF005276. SspB. 1 hit.
SUPFAMiSSF101738. SSF101738. 1 hit.

Sequencei

Sequence statusi: Complete.

P45206-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYKSSPKRP YLLRAYYDWL VDNSFTPYLV VDATYLGVNV PVEYVKDGQI
60 70 80 90 100
VLNLSASATG NLQLTNDFIQ FNARFKGVSR ELYIPMGAAL AIYARENGDG
110 120 130 140 150
VMFEPEEIYD ELNIEPDTEQ PTGFYEAVDK PKKREEKKKT KSVSHLRIVD
Length:150
Mass (Da):17,168
Last modified:November 1, 1995 - v1
Checksum:iE8A2E3BD550732A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC23089.1.
PIRiD64123.
RefSeqiNP_439592.1. NC_000907.1.
WP_005650453.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC23089; AAC23089; HI_1440.
GeneIDi950343.
KEGGihin:HI1440.
PATRICi20191585. VBIHaeInf48452_1502.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC23089.1.
PIRiD64123.
RefSeqiNP_439592.1. NC_000907.1.
WP_005650453.1. NC_000907.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OU8X-ray1.60A/B1-111[»]
1OU9X-ray1.80A/B/C1-129[»]
1OULX-ray2.20A/B1-129[»]
1TWBX-ray1.90A/B1-110[»]
1ZSZX-ray2.00A1-110[»]
B1-111[»]
C1-129[»]
ProteinModelPortaliP45206.
SMRiP45206. Positions 1-122.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI1440.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC23089; AAC23089; HI_1440.
GeneIDi950343.
KEGGihin:HI1440.
PATRICi20191585. VBIHaeInf48452_1502.

Phylogenomic databases

eggNOGiENOG4105KB2. Bacteria.
COG2969. LUCA.
KOiK03600.
OMAiNDFISFT.
PhylomeDBiP45206.

Miscellaneous databases

EvolutionaryTraceiP45206.

Family and domain databases

Gene3Di2.30.30.220. 1 hit.
InterProiIPR007481. SspB.
[Graphical view]
PfamiPF04386. SspB. 1 hit.
[Graphical view]
PIRSFiPIRSF005276. SspB. 1 hit.
SUPFAMiSSF101738. SSF101738. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSSPB_HAEIN
AccessioniPrimary (citable) accession number: P45206
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 7, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.