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Reviewed, UniProtKB/Swiss-Prot P45204 (ISPA_HAEIN)

Last modified November 3, 2009. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Geranyltranstransferase
    EC=2.5.1.10
Alternative name(s):
    Farnesyl-diphosphate synthase
      Short name=FPP synthase
Gene names
Name: ispA
Ordered Locus Names: HI1438
OrganismHaemophilus influenzae [Complete proteome] [HAMAP]
Taxonomic identifier727 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

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Protein attributes

Sequence length295 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

Geranyl diphosphate + isopentenyl diphosphate = diphosphate + trans,trans-farnesyl diphosphate.

Cofactor

Binds 3 magnesium ions per subunit By similarity.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the FPP/GGPP synthetase family.

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Ontologies

Keywords
   Biological processIsoprene biosynthesis
   Cellular componentCytoplasm
   LigandMagnesium
Metal-binding
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processisoprenoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functiongeranyltranstransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 295295Geranyltranstransferase
PRO_0000123983

Sites

Metal binding851Magnesium 1 By similarity
Metal binding851Magnesium 2 By similarity
Metal binding911Magnesium 1 By similarity
Metal binding911Magnesium 2 By similarity
Metal binding2231Magnesium 3 By similarity
Binding site461Isopentenyl diphosphate By similarity
Binding site491Isopentenyl diphosphate By similarity
Binding site781Isopentenyl diphosphate By similarity
Binding site961Geranyl diphosphate By similarity
Binding site971Isopentenyl diphosphate By similarity
Binding site1801Geranyl diphosphate By similarity
Binding site1811Geranyl diphosphate By similarity
Binding site2201Geranyl diphosphate By similarity
Binding site2371Geranyl diphosphate By similarity

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Sequences

Sequence LengthMass (Da)Tools
P45204-1 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: A64DE650266E670F

FASTA29532,407
        10         20         30         40         50         60 
MGHFSEELQQ VQTRINRFLE AQFEGIESHN APLLEAMKYA LLLGGKRVRP FLVYATGQML 

        70         80         90        100        110        120 
GAEKQTLDYA AAAIEAIHAY SLIHDDLPAM DDDNLRRGHP TCHIQFDEAT AILAGDALQS 

       130        140        150        160        170        180 
FAFEILTKTP NISTEQKLAL IQILAQGAGV QGMCLGQSLD LISEHKQISL SELELIHRNK 

       190        200        210        220        230        240 
TGALLIAALK LGFICSPHFT DKRLEQSLTQ YAEAIGLAFQ VQDDILDIEG DSAEIGKQVG 

       250        260        270        280        290 
ADLDLDKSTY PKLLGLSGAK QKAQDLYQSA LSELEKIPFD TTVRALAEFI ITRKS

« Hide

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Cross-references

Sequence databases

L42023 Genomic DNA. Translation: AAC23087.1.
PIRC64123.
RefSeqNP_439590.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID950833.
GenomeReviewsGene locus HI1438 in contig L42023_GR.
KEGGhin:HI1438.
NMPDRfig|71421.1.peg.1372.
TIGRHI1438.

Phylogenomic databases

HOGENOMP45204.
OMALDCYFEN.

Enzyme and pathway databases

BioCycHINF71421:HI_1438-MON.
BRENDA2.5.1.10. 109.

Family and domain databases

InterProIPR000092. Polyprenyl_synt.
IPR017446. Polyprenyl_synth-rel.
IPR008949. Terpenoid_synth.
[Graphical view]
Gene3DG3DSA:1.10.600.10. Terpenoid_synth. 1 hit.
PANTHERPTHR12001. Polyprenyl_synt. 1 hit.
PfamPF00348. polyprenyl_synt. 1 hit.
[Graphical view]
PROSITEPS00723. POLYPRENYL_SYNTHET_1. 1 hit.
PS00444. POLYPRENYL_SYNTHET_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameISPA_HAEIN
AccessionPrimary (citable) accession number: P45204
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 3, 2009
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents