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P45204 (ISPA_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Farnesyl diphosphate synthase
Short name=FPP synthase
EC=2.5.1.10
Alternative name(s):
(2E,6E)-farnesyl diphosphate synthase
Geranyltranstransferase
Gene names
Name:ispA
Ordered Locus Names:HI_1438
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length295 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate.

Cofactor

Binds 3 magnesium ions per subunit By similarity.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the FPP/GGPP synthase family.

Ontologies

Keywords
   Biological processIsoprene biosynthesis
   Cellular componentCytoplasm
   LigandMagnesium
Metal-binding
   Molecular functionTransferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processisoprenoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functiongeranyltranstransferase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 295295Farnesyl diphosphate synthase
PRO_0000123983

Sites

Metal binding851Magnesium 1 By similarity
Metal binding851Magnesium 2 By similarity
Metal binding911Magnesium 1 By similarity
Metal binding911Magnesium 2 By similarity
Metal binding2231Magnesium 3 By similarity
Binding site461Isopentenyl diphosphate By similarity
Binding site491Isopentenyl diphosphate By similarity
Binding site781Isopentenyl diphosphate By similarity
Binding site961Geranyl diphosphate By similarity
Binding site971Isopentenyl diphosphate By similarity
Binding site1801Geranyl diphosphate By similarity
Binding site1811Geranyl diphosphate By similarity
Binding site2201Geranyl diphosphate By similarity
Binding site2371Geranyl diphosphate By similarity

Sequences

Sequence LengthMass (Da)Tools
P45204 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: A64DE650266E670F

FASTA29532,407
        10         20         30         40         50         60 
MGHFSEELQQ VQTRINRFLE AQFEGIESHN APLLEAMKYA LLLGGKRVRP FLVYATGQML 

        70         80         90        100        110        120 
GAEKQTLDYA AAAIEAIHAY SLIHDDLPAM DDDNLRRGHP TCHIQFDEAT AILAGDALQS 

       130        140        150        160        170        180 
FAFEILTKTP NISTEQKLAL IQILAQGAGV QGMCLGQSLD LISEHKQISL SELELIHRNK 

       190        200        210        220        230        240 
TGALLIAALK LGFICSPHFT DKRLEQSLTQ YAEAIGLAFQ VQDDILDIEG DSAEIGKQVG 

       250        260        270        280        290 
ADLDLDKSTY PKLLGLSGAK QKAQDLYQSA LSELEKIPFD TTVRALAEFI ITRKS

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L42023 Genomic DNA. Translation: AAC23087.1.
PIRC64123.
RefSeqNP_439590.1. NC_000907.1.

3D structure databases

ProteinModelPortalP45204.
SMRP45204. Positions 4-294.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID950833.
GenomeReviewsGene locus HI_1438 in contig L42023_GR.
KEGGhin:HI1438.
NMPDRfig|71421.1.peg.1372.
PATRIC20191581. VBIHaeInf48452_1500.
TIGRHI_1438.

Phylogenomic databases

HOGENOMHBG732667.
OMANELCTEM.
ProtClustDBCLSK870150.

Enzyme and pathway databases

BioCycHINF71421:HI_1438-MONOMER.

Family and domain databases

InterProIPR000092. Polyprenyl_synt.
IPR017446. Polyprenyl_synth-rel.
IPR008949. Terpenoid_synth.
[Graphical view]
Gene3DG3DSA:1.10.600.10. Terpenoid_synth. 1 hit.
KOK00795.
PANTHERPTHR12001. Polyprenyl_synt. 1 hit.
PfamPF00348. polyprenyl_synt. 1 hit.
[Graphical view]
SUPFAMSSF48576. Terpenoid_synth. 1 hit.
PROSITEPS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameISPA_HAEIN
AccessionPrimary (citable) accession number: P45204
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 25, 2012
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names

SIMILARITY comments

Index of protein domains and families

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