P45189 (PHOB_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphate regulon transcriptional regulatory protein PhoB

Gene names

Name:	phoB
Ordered Locus Names:	HI_1379

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]

Taxonomic identifier

71421 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus › Haemophilus influenzae

Protein attributes

Sequence length	231 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This protein is a positive regulator for the phosphate regulon. Transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited By similarity.
Subcellular location	Cytoplasm By similarity.
Post-translational modification	Phosphorylated by PhoR By similarity.
Sequence similarities	Contains 1 response regulatory domain.

Ontologies

Keywords
Biological process	Phosphate transport Transcription Transcription regulation Transport Two-component regulatory system
Cellular component	Cytoplasm
Ligand	DNA-binding
Molecular function	Activator
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	intracellular signal transduction Inferred from electronic annotation. Source: GOC phosphate ion transport Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW phosphorelay response regulator activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 231	231	Phosphate regulon transcriptional regulatory protein PhoB		PRO_0000081188
Regions
	Domain	1 – 119	119	Response regulatory
Amino acid modifications
	Modified residue	52	1	4-aspartylphosphate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P45189 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: B90BF5FDD6BF414B	FASTA	231	27,508
	10 20 30 40 50 60 MTRKILIVED ECAIREMIAL FLSQKYYDVI EASDFKTAIN KIKENPKLIL LDWMLPGRSG 70 80 90 100 110 120 IQFIQYIKKQ ESYAAIPIIM LTAKSTEEDC IACLNAGADD YITKPFSPQI LLARIEAVWR 130 140 150 160 170 180 RIYEQQSQFI QIDELSIDEN AQRVFFQQQE INLSSTEFKL LHFFMRHPEK VYSREQLLNR 190 200 210 220 230 IWHNDLEVEY RTVDSYIRRL RRNLAPFQCE HYIQTVRGSG YRFSSYLRDK Q

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L42023 Genomic DNA. Translation: AAC23025.1.
PIR	F64120.
RefSeq	NP_439531.1. NC_000907.1.
3D structure databases
ProteinModelPortal	P45189.
ModBase	Search...
Protein-protein interaction databases
STRING	71421.HI1379.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC23025; AAC23025; HI_1379.
GeneID	950671.
KEGG	hin:HI1379.
PATRIC	20191447. VBIHaeInf48452_1434.
Phylogenomic databases
eggNOG	COG0745.
KO	K07657.
OMA	NDIYVED.
ProtClustDB	CLSK870093.
Family and domain databases
Gene3D	1.10.10.10. 1 hit.
InterPro	IPR011006. CheY-like_superfamily. IPR001867. Sig_transdc_resp-reg_C. IPR011879. Sig_transdc_resp-reg_PhoB. IPR001789. Sig_transdc_resp-reg_receiver. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF00072. Response_reg. 1 hit. PF00486. Trans_reg_C. 1 hit. [Graphical view]
SMART	SM00448. REC. 1 hit. SM00862. Trans_reg_C. 1 hit. [Graphical view]
SUPFAM	SSF52172. CheY_like. 1 hit.
TIGRFAMs	TIGR02154. PhoB. 1 hit.
PROSITE	PS50110. RESPONSE_REGULATORY. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PHOB_HAEIN

Accession

Primary (citable) accession number: P45189

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	May 1, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program