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Protein

Peptidase T

Gene

pepT

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cleaves the N-terminal amino acid of tripeptides.UniRule annotation

Catalytic activityi

Release of the N-terminal residue from a tripeptide.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi84Zinc 1UniRule annotation1
Active sitei86UniRule annotation1
Metal bindingi146Zinc 1UniRule annotation1
Metal bindingi146Zinc 2UniRule annotation1
Active sitei179Proton acceptorUniRule annotation1
Metal bindingi180Zinc 2UniRule annotation1
Metal bindingi202Zinc 1UniRule annotation1
Metal bindingi385Zinc 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM20.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidase TUniRule annotation (EC:3.4.11.4UniRule annotation)
Alternative name(s):
AminotripeptidaseUniRule annotation
Short name:
TripeptidaseUniRule annotation
Tripeptide aminopeptidaseUniRule annotation
Gene namesi
Name:pepTUniRule annotation
Ordered Locus Names:HI_1348
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001852981 – 412Peptidase TAdd BLAST412

Interactioni

Protein-protein interaction databases

STRINGi71421.HI1348.

Structurei

3D structure databases

ProteinModelPortaliP45172.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M20B family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D42. Bacteria.
COG2195. LUCA.
KOiK01258.
OMAiPNHKPIR.
PhylomeDBiP45172.

Family and domain databases

CDDicd03892. M20_peptT. 1 hit.
Gene3Di3.30.70.360. 1 hit.
HAMAPiMF_00550. Aminopeptidase_M20. 1 hit.
InterProiIPR001261. ArgE/DapE_CS.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
IPR010161. Peptidase_M20B.
[Graphical view]
PfamiPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
PIRSFiPIRSF037215. Peptidase_M20B. 1 hit.
SUPFAMiSSF55031. SSF55031. 1 hit.
TIGRFAMsiTIGR01882. peptidase-T. 1 hit.
PROSITEiPS00758. ARGE_DAPE_CPG2_1. 1 hit.
PS00759. ARGE_DAPE_CPG2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P45172-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISQIDKTEL LERFLHYVSF HTQSKPNAKH SPSSVGQMKL AMQLQKELIQ
60 70 80 90 100
LGLENVEVSK YAVVTAFLPA NDPNLTKTIG LVAHLDTSPQ CSGKNVRPEV
110 120 130 140 150
IEEYRGGDIA LGIGEEFISP VYYSFMQKLV GQTLIVTDGT TLLGADNKAG
160 170 180 190 200
IAEIMTALSI LQKENIPHCN IRVAFTPDEE IGLGIHYFPM EKFSCDWAYT
210 220 230 240 250
IDGGEVGELE YENFNAATAK VRFFGRNIHT GYAKGKMLNA LTLACEFQQV
260 270 280 290 300
FPVDEVPEKT DGKVGFYHLE DFSGDIEQVE LTYLIRDFDE QNFAQRKAFI
310 320 330 340 350
KNQVEKFNAK KGLKKPIELE IQDSYQNMYD VVKNVPQSIE LADRAMKAVG
360 370 380 390 400
IKPNHKPIRG GTDGAFLASK GLACPNIFTG GYNFHSKHEL VSLQGMENTV
410
QVIIEMLKCK DL
Length:412
Mass (Da):45,986
Last modified:November 1, 1995 - v1
Checksum:i7922E34B2B904A49
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22995.1.
PIRiC64118.
RefSeqiNP_439499.1. NC_000907.1.
WP_005694011.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22995; AAC22995; HI_1348.
GeneIDi950265.
KEGGihin:HI1348.
PATRICi20191381. VBIHaeInf48452_1401.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22995.1.
PIRiC64118.
RefSeqiNP_439499.1. NC_000907.1.
WP_005694011.1. NC_000907.1.

3D structure databases

ProteinModelPortaliP45172.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI1348.

Protein family/group databases

MEROPSiM20.003.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC22995; AAC22995; HI_1348.
GeneIDi950265.
KEGGihin:HI1348.
PATRICi20191381. VBIHaeInf48452_1401.

Phylogenomic databases

eggNOGiENOG4105D42. Bacteria.
COG2195. LUCA.
KOiK01258.
OMAiPNHKPIR.
PhylomeDBiP45172.

Family and domain databases

CDDicd03892. M20_peptT. 1 hit.
Gene3Di3.30.70.360. 1 hit.
HAMAPiMF_00550. Aminopeptidase_M20. 1 hit.
InterProiIPR001261. ArgE/DapE_CS.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
IPR010161. Peptidase_M20B.
[Graphical view]
PfamiPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
PIRSFiPIRSF037215. Peptidase_M20B. 1 hit.
SUPFAMiSSF55031. SSF55031. 1 hit.
TIGRFAMsiTIGR01882. peptidase-T. 1 hit.
PROSITEiPS00758. ARGE_DAPE_CPG2_1. 1 hit.
PS00759. ARGE_DAPE_CPG2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPEPT_HAEIN
AccessioniPrimary (citable) accession number: P45172
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 5, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.