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P45172

- PEPT_HAEIN

UniProt

P45172 - PEPT_HAEIN

Protein

Peptidase T

Gene

pepT

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Cleaves the N-terminal amino acid of tripeptides.UniRule annotation

    Catalytic activityi

    Release of the N-terminal residue from a tripeptide.UniRule annotation

    Cofactori

    Binds 2 zinc ions per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi84 – 841Zinc 1UniRule annotation
    Active sitei86 – 861UniRule annotation
    Metal bindingi146 – 1461Zinc 1UniRule annotation
    Metal bindingi146 – 1461Zinc 2UniRule annotation
    Active sitei179 – 1791Proton acceptorUniRule annotation
    Metal bindingi180 – 1801Zinc 2UniRule annotation
    Metal bindingi202 – 2021Zinc 1UniRule annotation
    Metal bindingi385 – 3851Zinc 2UniRule annotation

    GO - Molecular functioni

    1. metallopeptidase activity Source: UniProtKB-KW
    2. tripeptide aminopeptidase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. peptide metabolic process Source: InterPro

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiM20.003.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptidase TUniRule annotation (EC:3.4.11.4UniRule annotation)
    Alternative name(s):
    AminotripeptidaseUniRule annotation
    Short name:
    TripeptidaseUniRule annotation
    Tripeptide aminopeptidaseUniRule annotation
    Gene namesi
    Name:pepTUniRule annotation
    Ordered Locus Names:HI_1348
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 412412Peptidase TPRO_0000185298Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi71421.HI1348.

    Structurei

    3D structure databases

    ProteinModelPortaliP45172.
    SMRiP45172. Positions 9-408.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M20B family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2195.
    KOiK01258.
    OMAiYECFNAA.
    OrthoDBiEOG6SV59Q.
    PhylomeDBiP45172.

    Family and domain databases

    Gene3Di3.30.70.360. 1 hit.
    HAMAPiMF_00550. Aminopeptidase_M20.
    InterProiIPR001261. ArgE/DapE_CS.
    IPR002933. Peptidase_M20.
    IPR011650. Peptidase_M20_dimer.
    IPR010161. Peptidase_M20B.
    [Graphical view]
    PfamiPF07687. M20_dimer. 1 hit.
    PF01546. Peptidase_M20. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037215. Peptidase_M20B. 1 hit.
    SUPFAMiSSF55031. SSF55031. 1 hit.
    TIGRFAMsiTIGR01882. peptidase-T. 1 hit.
    PROSITEiPS00758. ARGE_DAPE_CPG2_1. 1 hit.
    PS00759. ARGE_DAPE_CPG2_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P45172-1 [UniParc]FASTAAdd to Basket

    « Hide

    MISQIDKTEL LERFLHYVSF HTQSKPNAKH SPSSVGQMKL AMQLQKELIQ    50
    LGLENVEVSK YAVVTAFLPA NDPNLTKTIG LVAHLDTSPQ CSGKNVRPEV 100
    IEEYRGGDIA LGIGEEFISP VYYSFMQKLV GQTLIVTDGT TLLGADNKAG 150
    IAEIMTALSI LQKENIPHCN IRVAFTPDEE IGLGIHYFPM EKFSCDWAYT 200
    IDGGEVGELE YENFNAATAK VRFFGRNIHT GYAKGKMLNA LTLACEFQQV 250
    FPVDEVPEKT DGKVGFYHLE DFSGDIEQVE LTYLIRDFDE QNFAQRKAFI 300
    KNQVEKFNAK KGLKKPIELE IQDSYQNMYD VVKNVPQSIE LADRAMKAVG 350
    IKPNHKPIRG GTDGAFLASK GLACPNIFTG GYNFHSKHEL VSLQGMENTV 400
    QVIIEMLKCK DL 412
    Length:412
    Mass (Da):45,986
    Last modified:November 1, 1995 - v1
    Checksum:i7922E34B2B904A49
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22995.1.
    PIRiC64118.
    RefSeqiNP_439499.1. NC_000907.1.
    WP_005694011.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC22995; AAC22995; HI_1348.
    GeneIDi950265.
    KEGGihin:HI1348.
    PATRICi20191381. VBIHaeInf48452_1401.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22995.1 .
    PIRi C64118.
    RefSeqi NP_439499.1. NC_000907.1.
    WP_005694011.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P45172.
    SMRi P45172. Positions 9-408.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI1348.

    Protein family/group databases

    MEROPSi M20.003.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC22995 ; AAC22995 ; HI_1348 .
    GeneIDi 950265.
    KEGGi hin:HI1348.
    PATRICi 20191381. VBIHaeInf48452_1401.

    Phylogenomic databases

    eggNOGi COG2195.
    KOi K01258.
    OMAi YECFNAA.
    OrthoDBi EOG6SV59Q.
    PhylomeDBi P45172.

    Family and domain databases

    Gene3Di 3.30.70.360. 1 hit.
    HAMAPi MF_00550. Aminopeptidase_M20.
    InterProi IPR001261. ArgE/DapE_CS.
    IPR002933. Peptidase_M20.
    IPR011650. Peptidase_M20_dimer.
    IPR010161. Peptidase_M20B.
    [Graphical view ]
    Pfami PF07687. M20_dimer. 1 hit.
    PF01546. Peptidase_M20. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037215. Peptidase_M20B. 1 hit.
    SUPFAMi SSF55031. SSF55031. 1 hit.
    TIGRFAMsi TIGR01882. peptidase-T. 1 hit.
    PROSITEi PS00758. ARGE_DAPE_CPG2_1. 1 hit.
    PS00759. ARGE_DAPE_CPG2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiPEPT_HAEIN
    AccessioniPrimary (citable) accession number: P45172
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3