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P45172

- PEPT_HAEIN

UniProt

P45172 - PEPT_HAEIN

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Protein
Peptidase T
Gene
pepT, HI_1348
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cleaves the N-terminal amino acid of tripeptides By similarity.UniRule annotation

Catalytic activityi

Release of the N-terminal residue from a tripeptide.UniRule annotation

Cofactori

Binds 2 zinc ions per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi84 – 841Zinc 1 By similarity
Active sitei86 – 861 By similarity
Metal bindingi146 – 1461Zinc 1 By similarity
Metal bindingi146 – 1461Zinc 2 By similarity
Active sitei179 – 1791Proton acceptor By similarity
Metal bindingi180 – 1801Zinc 2 By similarity
Metal bindingi202 – 2021Zinc 1 By similarity
Metal bindingi385 – 3851Zinc 2 By similarity

GO - Molecular functioni

  1. metallopeptidase activity Source: UniProtKB-KW
  2. tripeptide aminopeptidase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. peptide metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM20.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidase T (EC:3.4.11.4)
Alternative name(s):
Aminotripeptidase
Short name:
Tripeptidase
Tripeptide aminopeptidase
Gene namesi
Name:pepT
Ordered Locus Names:HI_1348
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 412412Peptidase TUniRule annotation
PRO_0000185298Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI1348.

Structurei

3D structure databases

ProteinModelPortaliP45172.
SMRiP45172. Positions 9-408.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M20B family.

Phylogenomic databases

eggNOGiCOG2195.
KOiK01258.
OMAiYECFNAA.
OrthoDBiEOG6SV59Q.
PhylomeDBiP45172.

Family and domain databases

Gene3Di3.30.70.360. 1 hit.
HAMAPiMF_00550. Aminopeptidase_M20.
InterProiIPR001261. ArgE/DapE_CS.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
IPR010161. Peptidase_M20B.
[Graphical view]
PfamiPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
PIRSFiPIRSF037215. Peptidase_M20B. 1 hit.
SUPFAMiSSF55031. SSF55031. 1 hit.
TIGRFAMsiTIGR01882. peptidase-T. 1 hit.
PROSITEiPS00758. ARGE_DAPE_CPG2_1. 1 hit.
PS00759. ARGE_DAPE_CPG2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P45172-1 [UniParc]FASTAAdd to Basket

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MISQIDKTEL LERFLHYVSF HTQSKPNAKH SPSSVGQMKL AMQLQKELIQ    50
LGLENVEVSK YAVVTAFLPA NDPNLTKTIG LVAHLDTSPQ CSGKNVRPEV 100
IEEYRGGDIA LGIGEEFISP VYYSFMQKLV GQTLIVTDGT TLLGADNKAG 150
IAEIMTALSI LQKENIPHCN IRVAFTPDEE IGLGIHYFPM EKFSCDWAYT 200
IDGGEVGELE YENFNAATAK VRFFGRNIHT GYAKGKMLNA LTLACEFQQV 250
FPVDEVPEKT DGKVGFYHLE DFSGDIEQVE LTYLIRDFDE QNFAQRKAFI 300
KNQVEKFNAK KGLKKPIELE IQDSYQNMYD VVKNVPQSIE LADRAMKAVG 350
IKPNHKPIRG GTDGAFLASK GLACPNIFTG GYNFHSKHEL VSLQGMENTV 400
QVIIEMLKCK DL 412
Length:412
Mass (Da):45,986
Last modified:November 1, 1995 - v1
Checksum:i7922E34B2B904A49
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22995.1.
PIRiC64118.
RefSeqiNP_439499.1. NC_000907.1.
WP_005694011.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22995; AAC22995; HI_1348.
GeneIDi950265.
KEGGihin:HI1348.
PATRICi20191381. VBIHaeInf48452_1401.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22995.1 .
PIRi C64118.
RefSeqi NP_439499.1. NC_000907.1.
WP_005694011.1. NC_000907.1.

3D structure databases

ProteinModelPortali P45172.
SMRi P45172. Positions 9-408.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI1348.

Protein family/group databases

MEROPSi M20.003.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC22995 ; AAC22995 ; HI_1348 .
GeneIDi 950265.
KEGGi hin:HI1348.
PATRICi 20191381. VBIHaeInf48452_1401.

Phylogenomic databases

eggNOGi COG2195.
KOi K01258.
OMAi YECFNAA.
OrthoDBi EOG6SV59Q.
PhylomeDBi P45172.

Family and domain databases

Gene3Di 3.30.70.360. 1 hit.
HAMAPi MF_00550. Aminopeptidase_M20.
InterProi IPR001261. ArgE/DapE_CS.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
IPR010161. Peptidase_M20B.
[Graphical view ]
Pfami PF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view ]
PIRSFi PIRSF037215. Peptidase_M20B. 1 hit.
SUPFAMi SSF55031. SSF55031. 1 hit.
TIGRFAMsi TIGR01882. peptidase-T. 1 hit.
PROSITEi PS00758. ARGE_DAPE_CPG2_1. 1 hit.
PS00759. ARGE_DAPE_CPG2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiPEPT_HAEIN
AccessioniPrimary (citable) accession number: P45172
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 3, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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