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P45161

- DACB_HAEIN

UniProt

P45161 - DACB_HAEIN

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Protein
D-alanyl-D-alanine carboxypeptidase DacB
Gene
dacB, HI_1330
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Not involved in transpeptidation but exclusively catalyzes a DD-carboxypeptidase and DD-endopeptidase reaction By similarity.

Catalytic activityi

Preferential cleavage: (Ac)(2)-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei69 – 691Acyl-ester intermediate By similarity
Active sitei72 – 721Proton acceptor By similarity
Active sitei310 – 3101 By similarity
Binding sitei420 – 4201Substrate By similarity

GO - Molecular functioni

  1. serine-type D-Ala-D-Ala carboxypeptidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
  4. regulation of cell shape Source: UniProtKB-KW
  5. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Protein family/group databases

MEROPSiS13.001.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanyl-D-alanine carboxypeptidase DacB (EC:3.4.16.4)
Short name:
DD-carboxypeptidase
Short name:
DD-peptidase
Alternative name(s):
D-alanyl-D-alanine endopeptidase (EC:3.4.21.-)
Short name:
DD-endopeptidase
Penicillin-binding protein 4
Short name:
PBP-4
Gene namesi
Name:dacB
Ordered Locus Names:HI_1330
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

Subcellular locationi

Periplasm Reviewed prediction

GO - Cellular componenti

  1. periplasmic space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 Reviewed prediction
Add
BLAST
Chaini27 – 479453D-alanyl-D-alanine carboxypeptidase DacB
PRO_0000027242Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI1330.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi30 – 345
Beta strandi42 – 498
Turni50 – 534
Beta strandi54 – 607
Helixi68 – 714
Helixi72 – 8211
Beta strandi90 – 978
Beta strandi108 – 1114
Helixi120 – 13213
Beta strandi142 – 1454
Helixi160 – 1623
Helixi166 – 1683
Helixi177 – 1793
Beta strandi180 – 1867
Beta strandi196 – 1983
Beta strandi206 – 2083
Beta strandi212 – 2143
Turni216 – 2183
Helixi219 – 2213
Beta strandi224 – 2296
Turni230 – 2323
Beta strandi233 – 2419
Beta strandi247 – 2526
Helixi256 – 27015
Beta strandi289 – 2957
Helixi299 – 30911
Helixi312 – 32716
Helixi333 – 34614
Beta strandi359 – 3613
Helixi370 – 38213
Helixi384 – 3874
Helixi390 – 3923
Turni396 – 3983
Helixi400 – 4023
Helixi406 – 4083
Turni411 – 4166
Beta strandi418 – 4247
Beta strandi427 – 4359
Beta strandi441 – 45010
Helixi463 – 47816

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3A3DX-ray1.60A/B28-479[»]
3A3EX-ray2.40A/B28-479[»]
3A3FX-ray2.10A/B28-479[»]
3A3IX-ray2.00A/B28-479[»]
ProteinModelPortaliP45161.

Miscellaneous databases

EvolutionaryTraceiP45161.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S13 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2027.
KOiK07259.
OMAiFRTIGHE.
OrthoDBiEOG6NGVQ4.
PhylomeDBiP45161.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR000667. Peptidase_S13.
[Graphical view]
PfamiPF02113. Peptidase_S13. 1 hit.
[Graphical view]
PRINTSiPR00922. DADACBPTASE3.
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR00666. PBP4. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P45161-1 [UniParc]FASTAAdd to Basket

« Hide

MKKLSSISTA LGSFLLSVSF SLPTFANINV SDLTQKLPEG SNVGFIAKNI    50
NQNQIIADYN GSTFMLSAST QKVFTAVAAK LALDDQFQFE TALLSNGKIQ 100
NGNLDGNLIV RFTGDPDLTR GQLYSLLAEL KKQGIKKING DLVLDTSVFS 150
SHDRGLGWIW NDLTMCFNSP PAAANIDNNC FYAELDANKN PGEIVKINVP 200
AQFPIQVFGQ VYVADSNEAP YCQLDVVVHD NNRYQVKGCL ARQYKPFGLS 250
FAVQNTDAYA AEIIQRQLRQ LGIEFNGKVL LPQKPQQGQL LAKHLSKPLP 300
DLLKKMMKKS DNQIADSLFR AVAFNYYKRP ASFQLGTLAV KSILQKQGIR 350
FGNSILADGS GLSRHNLVAP KTMLSVLEYI AKNEDKLHLM ETFPIAGVDG 400
TISGRGGLIS PPLVKNVIAK TGSLKGVYNL AGFMTNARGE KVAFVQFING 450
YSTGDLESKT KRAPLVQFER NLYNELYKY 479
Length:479
Mass (Da):52,686
Last modified:November 1, 1995 - v1
Checksum:i632868C61206CB48
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22975.1.
PIRiA64117.
RefSeqiNP_439482.1. NC_000907.1.
WP_005694445.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22975; AAC22975; HI_1330.
GeneIDi950252.
KEGGihin:HI1330.
PATRICi20191345. VBIHaeInf48452_1383.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22975.1 .
PIRi A64117.
RefSeqi NP_439482.1. NC_000907.1.
WP_005694445.1. NC_000907.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3A3D X-ray 1.60 A/B 28-479 [» ]
3A3E X-ray 2.40 A/B 28-479 [» ]
3A3F X-ray 2.10 A/B 28-479 [» ]
3A3I X-ray 2.00 A/B 28-479 [» ]
ProteinModelPortali P45161.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI1330.

Protein family/group databases

MEROPSi S13.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC22975 ; AAC22975 ; HI_1330 .
GeneIDi 950252.
KEGGi hin:HI1330.
PATRICi 20191345. VBIHaeInf48452_1383.

Phylogenomic databases

eggNOGi COG2027.
KOi K07259.
OMAi FRTIGHE.
OrthoDBi EOG6NGVQ4.
PhylomeDBi P45161.

Enzyme and pathway databases

UniPathwayi UPA00219 .

Miscellaneous databases

EvolutionaryTracei P45161.

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR000667. Peptidase_S13.
[Graphical view ]
Pfami PF02113. Peptidase_S13. 1 hit.
[Graphical view ]
PRINTSi PR00922. DADACBPTASE3.
SUPFAMi SSF56601. SSF56601. 1 hit.
TIGRFAMsi TIGR00666. PBP4. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiDACB_HAEIN
AccessioniPrimary (citable) accession number: P45161
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 3, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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