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P45159

- FABA_HAEIN

UniProt

P45159 - FABA_HAEIN

Protein

3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase

Gene

fabA

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length By similarity.By similarity

    Catalytic activityi

    A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H2O.
    (3R)-3-hydroxydecanoyl-[acyl-carrier-protein] = trans-dec-2-enoyl-[acyl-carrier-protein] + H2O.
    Trans-dec-2-enoyl-[acyl-carrier-protein] = cis-dec-3-enoyl-[acyl-carrier-protein].

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei76 – 761By similarity

    GO - Molecular functioni

    1. 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity Source: UniProtKB-HAMAP
    2. 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity Source: UniProtKB-EC
    3. trans-2-decenoyl-acyl-carrier-protein isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase, Lyase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    UniPathwayiUPA00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase (EC:4.2.1.59)
    Alternative name(s):
    3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA
    Beta-hydroxydecanoyl thioester dehydrase
    Trans-2-decenoyl-[acyl-carrier-protein] isomerase (EC:5.3.3.14)
    Gene namesi
    Name:fabA
    Ordered Locus Names:HI_1325
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 1771773-hydroxydecanoyl-[acyl-carrier-protein] dehydratasePRO_0000091599Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi71421.HI1325.

    Structurei

    3D structure databases

    ProteinModelPortaliP45159.
    SMRiP45159. Positions 7-177.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0764.
    KOiK01716.
    OMAiMGIADAT.
    OrthoDBiEOG6VB6SH.
    PhylomeDBiP45159.

    Family and domain databases

    Gene3Di3.10.129.10. 1 hit.
    HAMAPiMF_00405. FabA.
    InterProiIPR010083. FabA.
    IPR013114. FabA_FabZ.
    IPR029069. HotDog_dom.
    [Graphical view]
    PfamiPF07977. FabA. 1 hit.
    [Graphical view]
    SUPFAMiSSF54637. SSF54637. 1 hit.
    TIGRFAMsiTIGR01749. fabA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P45159-1 [UniParc]FASTAAdd to Basket

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    MQNACTLNKK SSYSYDDLLA SGRGELFGKE GPQLPAPTML MMDRIIEMNE    50
    ETGAFGKGYI EAELDIKPEL PFFGCHFIGD PVMPGCLGLD AMWQLVGFYL 100
    GWIGGKGKGR ALGVGEVKFT GQILPTAKKV VYRIHMKRVI NRKLVMGMAD 150
    GEVEVDGRVI YTATDLKVGL FQDTSTF 177
    Length:177
    Mass (Da):19,465
    Last modified:November 1, 1995 - v1
    Checksum:i17E272B39A11552D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22972.1.
    PIRiG64116.
    RefSeqiNP_439476.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC22972; AAC22972; HI_1325.
    GeneIDi950257.
    KEGGihin:HI1325.
    PATRICi20191333. VBIHaeInf48452_1377.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22972.1 .
    PIRi G64116.
    RefSeqi NP_439476.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P45159.
    SMRi P45159. Positions 7-177.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI1325.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC22972 ; AAC22972 ; HI_1325 .
    GeneIDi 950257.
    KEGGi hin:HI1325.
    PATRICi 20191333. VBIHaeInf48452_1377.

    Phylogenomic databases

    eggNOGi COG0764.
    KOi K01716.
    OMAi MGIADAT.
    OrthoDBi EOG6VB6SH.
    PhylomeDBi P45159.

    Enzyme and pathway databases

    UniPathwayi UPA00094 .

    Family and domain databases

    Gene3Di 3.10.129.10. 1 hit.
    HAMAPi MF_00405. FabA.
    InterProi IPR010083. FabA.
    IPR013114. FabA_FabZ.
    IPR029069. HotDog_dom.
    [Graphical view ]
    Pfami PF07977. FabA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54637. SSF54637. 1 hit.
    TIGRFAMsi TIGR01749. fabA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiFABA_HAEIN
    AccessioniPrimary (citable) accession number: P45159
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3