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P45159 (FABA_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase

EC=4.2.1.59
Alternative name(s):
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA
Beta-hydroxydecanoyl thioester dehydrase
Trans-2-decenoyl-[acyl-carrier-protein] isomerase
EC=5.3.3.14
Gene names
Name:fabA
Ordered Locus Names:HI_1325
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length177 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length By similarity. HAMAP-Rule MF_00405

Catalytic activity

A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H2O. HAMAP-Rule MF_00405

(3R)-3-hydroxydecanoyl-[acyl-carrier-protein] = trans-dec-2-enoyl-[acyl-carrier-protein] + H2O. HAMAP-Rule MF_00405

Trans-dec-2-enoyl-[acyl-carrier-protein] = cis-dec-3-enoyl-[acyl-carrier-protein]. HAMAP-Rule MF_00405

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP-Rule MF_00405

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00405

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00405.

Sequence similarities

Belongs to the thioester dehydratase family. FabA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 1771773-hydroxydecanoyl-[acyl-carrier-protein] dehydratase HAMAP-Rule MF_00405
PRO_0000091599

Sites

Active site761 By similarity

Sequences

Sequence LengthMass (Da)Tools
P45159 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 17E272B39A11552D

FASTA17719,465
        10         20         30         40         50         60 
MQNACTLNKK SSYSYDDLLA SGRGELFGKE GPQLPAPTML MMDRIIEMNE ETGAFGKGYI 

        70         80         90        100        110        120 
EAELDIKPEL PFFGCHFIGD PVMPGCLGLD AMWQLVGFYL GWIGGKGKGR ALGVGEVKFT 

       130        140        150        160        170 
GQILPTAKKV VYRIHMKRVI NRKLVMGMAD GEVEVDGRVI YTATDLKVGL FQDTSTF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC22972.1.
PIRG64116.
RefSeqNP_439476.1. NC_000907.1.

3D structure databases

ProteinModelPortalP45159.
SMRP45159. Positions 7-177.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI1325.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC22972; AAC22972; HI_1325.
GeneID950257.
KEGGhin:HI1325.
PATRIC20191333. VBIHaeInf48452_1377.

Phylogenomic databases

eggNOGCOG0764.
KOK01716.
OMAMGIADAT.
OrthoDBEOG6VB6SH.
PhylomeDBP45159.

Enzyme and pathway databases

UniPathwayUPA00094.

Family and domain databases

Gene3D3.10.129.10. 1 hit.
HAMAPMF_00405. FabA.
InterProIPR010083. FabA.
IPR013114. FabA_FabZ.
IPR029069. HotDog_dom.
[Graphical view]
PfamPF07977. FabA. 1 hit.
[Graphical view]
SUPFAMSSF54637. SSF54637. 1 hit.
TIGRFAMsTIGR01749. fabA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameFABA_HAEIN
AccessionPrimary (citable) accession number: P45159
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names