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P45159

- FABA_HAEIN

UniProt

P45159 - FABA_HAEIN

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Protein

3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase

Gene
fabA, HI_1325
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length By similarity.UniRule annotation

Catalytic activityi

A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H2O.UniRule annotation
(3R)-3-hydroxydecanoyl-[acyl-carrier-protein] = trans-dec-2-enoyl-[acyl-carrier-protein] + H2O.UniRule annotation
Trans-dec-2-enoyl-[acyl-carrier-protein] = cis-dec-3-enoyl-[acyl-carrier-protein].UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei76 – 761 By similarity

GO - Molecular functioni

  1. 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity Source: UniProtKB-HAMAP
  2. 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity Source: UniProtKB-EC
  3. trans-2-decenoyl-acyl-carrier-protein isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Lyase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase (EC:4.2.1.59)
Alternative name(s):
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA
Beta-hydroxydecanoyl thioester dehydrase
Trans-2-decenoyl-[acyl-carrier-protein] isomerase (EC:5.3.3.14)
Gene namesi
Name:fabA
Ordered Locus Names:HI_1325
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 1771773-hydroxydecanoyl-[acyl-carrier-protein] dehydrataseUniRule annotationPRO_0000091599Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi71421.HI1325.

Structurei

3D structure databases

ProteinModelPortaliP45159.
SMRiP45159. Positions 7-177.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0764.
KOiK01716.
OMAiMGIADAT.
OrthoDBiEOG6VB6SH.
PhylomeDBiP45159.

Family and domain databases

Gene3Di3.10.129.10. 1 hit.
HAMAPiMF_00405. FabA.
InterProiIPR010083. FabA.
IPR013114. FabA_FabZ.
IPR029069. HotDog_dom.
[Graphical view]
PfamiPF07977. FabA. 1 hit.
[Graphical view]
SUPFAMiSSF54637. SSF54637. 1 hit.
TIGRFAMsiTIGR01749. fabA. 1 hit.

Sequencei

Sequence statusi: Complete.

P45159-1 [UniParc]FASTAAdd to Basket

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MQNACTLNKK SSYSYDDLLA SGRGELFGKE GPQLPAPTML MMDRIIEMNE    50
ETGAFGKGYI EAELDIKPEL PFFGCHFIGD PVMPGCLGLD AMWQLVGFYL 100
GWIGGKGKGR ALGVGEVKFT GQILPTAKKV VYRIHMKRVI NRKLVMGMAD 150
GEVEVDGRVI YTATDLKVGL FQDTSTF 177
Length:177
Mass (Da):19,465
Last modified:November 1, 1995 - v1
Checksum:i17E272B39A11552D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22972.1.
PIRiG64116.
RefSeqiNP_439476.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22972; AAC22972; HI_1325.
GeneIDi950257.
KEGGihin:HI1325.
PATRICi20191333. VBIHaeInf48452_1377.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22972.1 .
PIRi G64116.
RefSeqi NP_439476.1. NC_000907.1.

3D structure databases

ProteinModelPortali P45159.
SMRi P45159. Positions 7-177.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI1325.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC22972 ; AAC22972 ; HI_1325 .
GeneIDi 950257.
KEGGi hin:HI1325.
PATRICi 20191333. VBIHaeInf48452_1377.

Phylogenomic databases

eggNOGi COG0764.
KOi K01716.
OMAi MGIADAT.
OrthoDBi EOG6VB6SH.
PhylomeDBi P45159.

Enzyme and pathway databases

UniPathwayi UPA00094 .

Family and domain databases

Gene3Di 3.10.129.10. 1 hit.
HAMAPi MF_00405. FabA.
InterProi IPR010083. FabA.
IPR013114. FabA_FabZ.
IPR029069. HotDog_dom.
[Graphical view ]
Pfami PF07977. FabA. 1 hit.
[Graphical view ]
SUPFAMi SSF54637. SSF54637. 1 hit.
TIGRFAMsi TIGR01749. fabA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiFABA_HAEIN
AccessioniPrimary (citable) accession number: P45159
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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