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P45148

- CAN_HAEIN

UniProt

P45148 - CAN_HAEIN

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Protein
Carbonic anhydrase 2
Gene
can, HI_1301
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

H2CO3 = CO2 + H2O.

Cofactori

Binds 1 zinc ion per subunit.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi42 – 421Zinc
Metal bindingi44 – 441Zinc
Metal bindingi98 – 981Zinc
Metal bindingi101 – 1011Zinc

GO - Molecular functioni

  1. carbonate dehydratase activity Source: UniProtKB
  2. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. carbon utilization Source: UniProtKB
  2. metabolic process Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Carbonic anhydrase 2 (EC:4.2.1.1)
Alternative name(s):
Carbonate dehydratase 2
Gene namesi
Name:can
Ordered Locus Names:HI_1301
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 229229Carbonic anhydrase 2
PRO_0000077467Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI1301.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi2 – 2019
Helixi25 – 317
Beta strandi37 – 426
Turni43 – 453
Helixi49 – 535
Beta strandi59 – 657
Helixi66 – 683
Helixi75 – 8612
Beta strandi92 – 1009
Helixi102 – 1087
Helixi116 – 12914
Helixi131 – 1355
Helixi139 – 1413
Helixi142 – 15918
Helixi162 – 1698
Beta strandi175 – 1817
Turni183 – 1853
Beta strandi188 – 19710
Helixi198 – 21215
Helixi217 – 2193

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2A8CX-ray2.30A/B/C/D/E/F1-229[»]
2A8DX-ray2.20A/B/C/D/E/F1-229[»]
3E1VX-ray2.80A/B1-229[»]
3E1WX-ray2.60A/B1-229[»]
3E24X-ray2.30A/B1-229[»]
3E28X-ray2.50A/B/C/D/E/F1-229[»]
3E2AX-ray2.30A/B/C/D/E/F1-229[»]
3E2WX-ray2.30A/B/C/D/E/F1-229[»]
3E2XX-ray2.55A/B1-229[»]
3E31X-ray2.95A/B1-229[»]
3E3FX-ray2.30A/B1-229[»]
3E3GX-ray2.30A/B/C/D/E/F1-229[»]
3E3IX-ray2.00A/B/C/D/E/F/G/H/I/J/K/L1-229[»]
3MF3X-ray2.50A/B/C/D/E/F1-221[»]
ProteinModelPortaliP45148.

Miscellaneous databases

EvolutionaryTraceiP45148.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0288.
KOiK01673.
OMAiCELNVAE.
OrthoDBiEOG6FFSB8.
PhylomeDBiP45148.

Family and domain databases

Gene3Di3.40.1050.10. 1 hit.
InterProiIPR001765. Carbonic_anhydrase.
IPR015892. Carbonic_anhydrase_CS.
[Graphical view]
PANTHERiPTHR11002. PTHR11002. 1 hit.
PfamiPF00484. Pro_CA. 1 hit.
[Graphical view]
SMARTiSM00947. Pro_CA. 1 hit.
[Graphical view]
SUPFAMiSSF53056. SSF53056. 1 hit.
PROSITEiPS00704. PROK_CO2_ANHYDRASE_1. 1 hit.
PS00705. PROK_CO2_ANHYDRASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P45148-1 [UniParc]FASTAAdd to Basket

« Hide

MDKIKQLFAN NYSWAQRMKE ENSTYFKELA DHQTPHYLWI GCSDSRVPAE    50
KLTNLEPGEL FVHRNVANQV IHTDFNCLSV VQYAVDVLKI EHIIICGHTN 100
CGGIHAAMAD KDLGLINNWL LHIRDIWFKH GHLLGKLSPE KRADMLTKIN 150
VAEQVYNLGR TSIVKSAWER GQKLSLHGWV YDVNDGFLVD QGVMATSRET 200
LEISYRNAIA RLSILDEENI LKKDHLENT 229
Length:229
Mass (Da):26,250
Last modified:November 1, 1995 - v1
Checksum:i4EB20478BC9EB6C9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22946.1.
PIRiF64170.
RefSeqiNP_439452.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22946; AAC22946; HI_1301.
GeneIDi950229.
KEGGihin:HI1301.
PATRICi20191285. VBIHaeInf48452_1353.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22946.1 .
PIRi F64170.
RefSeqi NP_439452.1. NC_000907.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2A8C X-ray 2.30 A/B/C/D/E/F 1-229 [» ]
2A8D X-ray 2.20 A/B/C/D/E/F 1-229 [» ]
3E1V X-ray 2.80 A/B 1-229 [» ]
3E1W X-ray 2.60 A/B 1-229 [» ]
3E24 X-ray 2.30 A/B 1-229 [» ]
3E28 X-ray 2.50 A/B/C/D/E/F 1-229 [» ]
3E2A X-ray 2.30 A/B/C/D/E/F 1-229 [» ]
3E2W X-ray 2.30 A/B/C/D/E/F 1-229 [» ]
3E2X X-ray 2.55 A/B 1-229 [» ]
3E31 X-ray 2.95 A/B 1-229 [» ]
3E3F X-ray 2.30 A/B 1-229 [» ]
3E3G X-ray 2.30 A/B/C/D/E/F 1-229 [» ]
3E3I X-ray 2.00 A/B/C/D/E/F/G/H/I/J/K/L 1-229 [» ]
3MF3 X-ray 2.50 A/B/C/D/E/F 1-221 [» ]
ProteinModelPortali P45148.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI1301.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC22946 ; AAC22946 ; HI_1301 .
GeneIDi 950229.
KEGGi hin:HI1301.
PATRICi 20191285. VBIHaeInf48452_1353.

Phylogenomic databases

eggNOGi COG0288.
KOi K01673.
OMAi CELNVAE.
OrthoDBi EOG6FFSB8.
PhylomeDBi P45148.

Miscellaneous databases

EvolutionaryTracei P45148.

Family and domain databases

Gene3Di 3.40.1050.10. 1 hit.
InterProi IPR001765. Carbonic_anhydrase.
IPR015892. Carbonic_anhydrase_CS.
[Graphical view ]
PANTHERi PTHR11002. PTHR11002. 1 hit.
Pfami PF00484. Pro_CA. 1 hit.
[Graphical view ]
SMARTi SM00947. Pro_CA. 1 hit.
[Graphical view ]
SUPFAMi SSF53056. SSF53056. 1 hit.
PROSITEi PS00704. PROK_CO2_ANHYDRASE_1. 1 hit.
PS00705. PROK_CO2_ANHYDRASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
  2. "Identification of a novel noncatalytic bicarbonate binding site in eubacterial beta-carbonic anhydrase."
    Cronk J.D., Rowlett R.S., Zhang K.Y., Tu C., Endrizzi J.A., Lee J., Gareiss P.C., Preiss J.R.
    Biochemistry 45:4351-4361(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS), ZINC-BINDING.

Entry informationi

Entry nameiCAN_HAEIN
AccessioniPrimary (citable) accession number: P45148
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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