Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P45148

- CAN_HAEIN

UniProt

P45148 - CAN_HAEIN

Protein

Carbonic anhydrase 2

Gene

can

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    H2CO3 = CO2 + H2O.

    Cofactori

    Binds 1 zinc ion per subunit.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi42 – 421Zinc
    Metal bindingi44 – 441Zinc
    Metal bindingi98 – 981Zinc
    Metal bindingi101 – 1011Zinc

    GO - Molecular functioni

    1. carbonate dehydratase activity Source: UniProtKB
    2. zinc ion binding Source: UniProtKB

    GO - Biological processi

    1. carbon utilization Source: UniProtKB
    2. metabolic process Source: GOC

    Keywords - Molecular functioni

    Lyase

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carbonic anhydrase 2 (EC:4.2.1.1)
    Alternative name(s):
    Carbonate dehydratase 2
    Gene namesi
    Name:can
    Ordered Locus Names:HI_1301
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 229229Carbonic anhydrase 2PRO_0000077467Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi71421.HI1301.

    Structurei

    Secondary structure

    1
    229
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi2 – 2019
    Helixi25 – 317
    Beta strandi37 – 426
    Turni43 – 453
    Helixi49 – 535
    Beta strandi59 – 657
    Helixi66 – 683
    Helixi75 – 8612
    Beta strandi92 – 1009
    Helixi102 – 1087
    Helixi116 – 12914
    Helixi131 – 1355
    Helixi139 – 1413
    Helixi142 – 15918
    Helixi162 – 1698
    Beta strandi175 – 1817
    Turni183 – 1853
    Beta strandi188 – 19710
    Helixi198 – 21215
    Helixi217 – 2193

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2A8CX-ray2.30A/B/C/D/E/F1-229[»]
    2A8DX-ray2.20A/B/C/D/E/F1-229[»]
    3E1VX-ray2.80A/B1-229[»]
    3E1WX-ray2.60A/B1-229[»]
    3E24X-ray2.30A/B1-229[»]
    3E28X-ray2.50A/B/C/D/E/F1-229[»]
    3E2AX-ray2.30A/B/C/D/E/F1-229[»]
    3E2WX-ray2.30A/B/C/D/E/F1-229[»]
    3E2XX-ray2.55A/B1-229[»]
    3E31X-ray2.95A/B1-229[»]
    3E3FX-ray2.30A/B1-229[»]
    3E3GX-ray2.30A/B/C/D/E/F1-229[»]
    3E3IX-ray2.00A/B/C/D/E/F/G/H/I/J/K/L1-229[»]
    3MF3X-ray2.50A/B/C/D/E/F1-221[»]
    ProteinModelPortaliP45148.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP45148.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0288.
    KOiK01673.
    OMAiCELNVAE.
    OrthoDBiEOG6FFSB8.
    PhylomeDBiP45148.

    Family and domain databases

    Gene3Di3.40.1050.10. 1 hit.
    InterProiIPR001765. Carbonic_anhydrase.
    IPR015892. Carbonic_anhydrase_CS.
    [Graphical view]
    PANTHERiPTHR11002. PTHR11002. 1 hit.
    PfamiPF00484. Pro_CA. 1 hit.
    [Graphical view]
    SMARTiSM00947. Pro_CA. 1 hit.
    [Graphical view]
    SUPFAMiSSF53056. SSF53056. 1 hit.
    PROSITEiPS00704. PROK_CO2_ANHYDRASE_1. 1 hit.
    PS00705. PROK_CO2_ANHYDRASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P45148-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDKIKQLFAN NYSWAQRMKE ENSTYFKELA DHQTPHYLWI GCSDSRVPAE    50
    KLTNLEPGEL FVHRNVANQV IHTDFNCLSV VQYAVDVLKI EHIIICGHTN 100
    CGGIHAAMAD KDLGLINNWL LHIRDIWFKH GHLLGKLSPE KRADMLTKIN 150
    VAEQVYNLGR TSIVKSAWER GQKLSLHGWV YDVNDGFLVD QGVMATSRET 200
    LEISYRNAIA RLSILDEENI LKKDHLENT 229
    Length:229
    Mass (Da):26,250
    Last modified:November 1, 1995 - v1
    Checksum:i4EB20478BC9EB6C9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22946.1.
    PIRiF64170.
    RefSeqiNP_439452.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC22946; AAC22946; HI_1301.
    GeneIDi950229.
    KEGGihin:HI1301.
    PATRICi20191285. VBIHaeInf48452_1353.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22946.1 .
    PIRi F64170.
    RefSeqi NP_439452.1. NC_000907.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2A8C X-ray 2.30 A/B/C/D/E/F 1-229 [» ]
    2A8D X-ray 2.20 A/B/C/D/E/F 1-229 [» ]
    3E1V X-ray 2.80 A/B 1-229 [» ]
    3E1W X-ray 2.60 A/B 1-229 [» ]
    3E24 X-ray 2.30 A/B 1-229 [» ]
    3E28 X-ray 2.50 A/B/C/D/E/F 1-229 [» ]
    3E2A X-ray 2.30 A/B/C/D/E/F 1-229 [» ]
    3E2W X-ray 2.30 A/B/C/D/E/F 1-229 [» ]
    3E2X X-ray 2.55 A/B 1-229 [» ]
    3E31 X-ray 2.95 A/B 1-229 [» ]
    3E3F X-ray 2.30 A/B 1-229 [» ]
    3E3G X-ray 2.30 A/B/C/D/E/F 1-229 [» ]
    3E3I X-ray 2.00 A/B/C/D/E/F/G/H/I/J/K/L 1-229 [» ]
    3MF3 X-ray 2.50 A/B/C/D/E/F 1-221 [» ]
    ProteinModelPortali P45148.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI1301.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC22946 ; AAC22946 ; HI_1301 .
    GeneIDi 950229.
    KEGGi hin:HI1301.
    PATRICi 20191285. VBIHaeInf48452_1353.

    Phylogenomic databases

    eggNOGi COG0288.
    KOi K01673.
    OMAi CELNVAE.
    OrthoDBi EOG6FFSB8.
    PhylomeDBi P45148.

    Miscellaneous databases

    EvolutionaryTracei P45148.

    Family and domain databases

    Gene3Di 3.40.1050.10. 1 hit.
    InterProi IPR001765. Carbonic_anhydrase.
    IPR015892. Carbonic_anhydrase_CS.
    [Graphical view ]
    PANTHERi PTHR11002. PTHR11002. 1 hit.
    Pfami PF00484. Pro_CA. 1 hit.
    [Graphical view ]
    SMARTi SM00947. Pro_CA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53056. SSF53056. 1 hit.
    PROSITEi PS00704. PROK_CO2_ANHYDRASE_1. 1 hit.
    PS00705. PROK_CO2_ANHYDRASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
    2. "Identification of a novel noncatalytic bicarbonate binding site in eubacterial beta-carbonic anhydrase."
      Cronk J.D., Rowlett R.S., Zhang K.Y., Tu C., Endrizzi J.A., Lee J., Gareiss P.C., Preiss J.R.
      Biochemistry 45:4351-4361(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS), ZINC-BINDING.

    Entry informationi

    Entry nameiCAN_HAEIN
    AccessioniPrimary (citable) accession number: P45148
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3