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P45148

- CAN_HAEIN

UniProt

P45148 - CAN_HAEIN

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Protein

Carbonic anhydrase 2

Gene

can

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

H2CO3 = CO2 + H2O.

Cofactori

Binds 1 zinc ion per subunit.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi42 – 421Zinc
Metal bindingi44 – 441Zinc
Metal bindingi98 – 981Zinc
Metal bindingi101 – 1011Zinc

GO - Molecular functioni

  1. carbonate dehydratase activity Source: UniProtKB
  2. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. carbon utilization Source: UniProtKB
  2. metabolic process Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Carbonic anhydrase 2 (EC:4.2.1.1)
Alternative name(s):
Carbonate dehydratase 2
Gene namesi
Name:can
Ordered Locus Names:HI_1301
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 229229Carbonic anhydrase 2PRO_0000077467Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI1301.

Structurei

Secondary structure

1
229
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi2 – 2019
Helixi25 – 317
Beta strandi37 – 426
Turni43 – 453
Helixi49 – 535
Beta strandi59 – 657
Helixi66 – 683
Helixi75 – 8612
Beta strandi92 – 1009
Helixi102 – 1087
Helixi116 – 12914
Helixi131 – 1355
Helixi139 – 1413
Helixi142 – 15918
Helixi162 – 1698
Beta strandi175 – 1817
Turni183 – 1853
Beta strandi188 – 19710
Helixi198 – 21215
Helixi217 – 2193

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2A8CX-ray2.30A/B/C/D/E/F1-229[»]
2A8DX-ray2.20A/B/C/D/E/F1-229[»]
3E1VX-ray2.80A/B1-229[»]
3E1WX-ray2.60A/B1-229[»]
3E24X-ray2.30A/B1-229[»]
3E28X-ray2.50A/B/C/D/E/F1-229[»]
3E2AX-ray2.30A/B/C/D/E/F1-229[»]
3E2WX-ray2.30A/B/C/D/E/F1-229[»]
3E2XX-ray2.55A/B1-229[»]
3E31X-ray2.95A/B1-229[»]
3E3FX-ray2.30A/B1-229[»]
3E3GX-ray2.30A/B/C/D/E/F1-229[»]
3E3IX-ray2.00A/B/C/D/E/F/G/H/I/J/K/L1-229[»]
3MF3X-ray2.50A/B/C/D/E/F1-221[»]
ProteinModelPortaliP45148.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP45148.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0288.
KOiK01673.
OMAiCELNVAE.
OrthoDBiEOG6FFSB8.
PhylomeDBiP45148.

Family and domain databases

Gene3Di3.40.1050.10. 1 hit.
InterProiIPR001765. Carbonic_anhydrase.
IPR015892. Carbonic_anhydrase_CS.
[Graphical view]
PANTHERiPTHR11002. PTHR11002. 1 hit.
PfamiPF00484. Pro_CA. 1 hit.
[Graphical view]
SMARTiSM00947. Pro_CA. 1 hit.
[Graphical view]
SUPFAMiSSF53056. SSF53056. 1 hit.
PROSITEiPS00704. PROK_CO2_ANHYDRASE_1. 1 hit.
PS00705. PROK_CO2_ANHYDRASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P45148-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDKIKQLFAN NYSWAQRMKE ENSTYFKELA DHQTPHYLWI GCSDSRVPAE
60 70 80 90 100
KLTNLEPGEL FVHRNVANQV IHTDFNCLSV VQYAVDVLKI EHIIICGHTN
110 120 130 140 150
CGGIHAAMAD KDLGLINNWL LHIRDIWFKH GHLLGKLSPE KRADMLTKIN
160 170 180 190 200
VAEQVYNLGR TSIVKSAWER GQKLSLHGWV YDVNDGFLVD QGVMATSRET
210 220
LEISYRNAIA RLSILDEENI LKKDHLENT
Length:229
Mass (Da):26,250
Last modified:November 1, 1995 - v1
Checksum:i4EB20478BC9EB6C9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22946.1.
PIRiF64170.
RefSeqiNP_439452.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22946; AAC22946; HI_1301.
GeneIDi950229.
KEGGihin:HI1301.
PATRICi20191285. VBIHaeInf48452_1353.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22946.1 .
PIRi F64170.
RefSeqi NP_439452.1. NC_000907.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2A8C X-ray 2.30 A/B/C/D/E/F 1-229 [» ]
2A8D X-ray 2.20 A/B/C/D/E/F 1-229 [» ]
3E1V X-ray 2.80 A/B 1-229 [» ]
3E1W X-ray 2.60 A/B 1-229 [» ]
3E24 X-ray 2.30 A/B 1-229 [» ]
3E28 X-ray 2.50 A/B/C/D/E/F 1-229 [» ]
3E2A X-ray 2.30 A/B/C/D/E/F 1-229 [» ]
3E2W X-ray 2.30 A/B/C/D/E/F 1-229 [» ]
3E2X X-ray 2.55 A/B 1-229 [» ]
3E31 X-ray 2.95 A/B 1-229 [» ]
3E3F X-ray 2.30 A/B 1-229 [» ]
3E3G X-ray 2.30 A/B/C/D/E/F 1-229 [» ]
3E3I X-ray 2.00 A/B/C/D/E/F/G/H/I/J/K/L 1-229 [» ]
3MF3 X-ray 2.50 A/B/C/D/E/F 1-221 [» ]
ProteinModelPortali P45148.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI1301.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC22946 ; AAC22946 ; HI_1301 .
GeneIDi 950229.
KEGGi hin:HI1301.
PATRICi 20191285. VBIHaeInf48452_1353.

Phylogenomic databases

eggNOGi COG0288.
KOi K01673.
OMAi CELNVAE.
OrthoDBi EOG6FFSB8.
PhylomeDBi P45148.

Miscellaneous databases

EvolutionaryTracei P45148.

Family and domain databases

Gene3Di 3.40.1050.10. 1 hit.
InterProi IPR001765. Carbonic_anhydrase.
IPR015892. Carbonic_anhydrase_CS.
[Graphical view ]
PANTHERi PTHR11002. PTHR11002. 1 hit.
Pfami PF00484. Pro_CA. 1 hit.
[Graphical view ]
SMARTi SM00947. Pro_CA. 1 hit.
[Graphical view ]
SUPFAMi SSF53056. SSF53056. 1 hit.
PROSITEi PS00704. PROK_CO2_ANHYDRASE_1. 1 hit.
PS00705. PROK_CO2_ANHYDRASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
  2. "Identification of a novel noncatalytic bicarbonate binding site in eubacterial beta-carbonic anhydrase."
    Cronk J.D., Rowlett R.S., Zhang K.Y., Tu C., Endrizzi J.A., Lee J., Gareiss P.C., Preiss J.R.
    Biochemistry 45:4351-4361(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS), ZINC-BINDING.

Entry informationi

Entry nameiCAN_HAEIN
AccessioniPrimary (citable) accession number: P45148
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 1, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3