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P45148 (CAN_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Carbonic anhydrase 2

EC=4.2.1.1
Alternative name(s):
Carbonate dehydratase 2
Gene names
Name:can
Ordered Locus Names:HI_1301
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length229 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

H2CO3 = CO2 + H2O.

Cofactor

Binds 1 zinc ion per subunit.

Sequence similarities

Belongs to the beta-class carbonic anhydrase family.

Ontologies

Keywords
   LigandMetal-binding
Zinc
   Molecular functionLyase
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcarbon utilization

Inferred from direct assay Ref.2. Source: UniProtKB

metabolic process

Inferred from direct assay Ref.2. Source: GOC

   Molecular_functioncarbonate dehydratase activity

Inferred from direct assay Ref.2. Source: UniProtKB

zinc ion binding

Inferred from direct assay Ref.2. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 229229Carbonic anhydrase 2
PRO_0000077467

Sites

Metal binding421Zinc
Metal binding441Zinc
Metal binding981Zinc
Metal binding1011Zinc

Secondary structure

..................................... 229
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P45148 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 4EB20478BC9EB6C9

FASTA22926,250
        10         20         30         40         50         60 
MDKIKQLFAN NYSWAQRMKE ENSTYFKELA DHQTPHYLWI GCSDSRVPAE KLTNLEPGEL 

        70         80         90        100        110        120 
FVHRNVANQV IHTDFNCLSV VQYAVDVLKI EHIIICGHTN CGGIHAAMAD KDLGLINNWL 

       130        140        150        160        170        180 
LHIRDIWFKH GHLLGKLSPE KRADMLTKIN VAEQVYNLGR TSIVKSAWER GQKLSLHGWV 

       190        200        210        220 
YDVNDGFLVD QGVMATSRET LEISYRNAIA RLSILDEENI LKKDHLENT 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC22946.1.
PIRF64170.
RefSeqNP_439452.1. NC_000907.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2A8CX-ray2.30A/B/C/D/E/F1-229[»]
2A8DX-ray2.20A/B/C/D/E/F1-229[»]
3E1VX-ray2.80A/B1-229[»]
3E1WX-ray2.60A/B1-229[»]
3E24X-ray2.30A/B1-229[»]
3E28X-ray2.50A/B/C/D/E/F1-229[»]
3E2AX-ray2.30A/B/C/D/E/F1-229[»]
3E2WX-ray2.30A/B/C/D/E/F1-229[»]
3E2XX-ray2.55A/B1-229[»]
3E31X-ray2.95A/B1-229[»]
3E3FX-ray2.30A/B1-229[»]
3E3GX-ray2.30A/B/C/D/E/F1-229[»]
3E3IX-ray2.00A/B/C/D/E/F/G/H/I/J/K/L1-229[»]
3MF3X-ray2.50A/B/C/D/E/F1-221[»]
ProteinModelPortalP45148.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI1301.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC22946; AAC22946; HI_1301.
GeneID950229.
KEGGhin:HI1301.
PATRIC20191285. VBIHaeInf48452_1353.

Phylogenomic databases

eggNOGCOG0288.
KOK01673.
OMARASMQDR.
OrthoDBEOG6FFSB8.
ProtClustDBCLSK870162.

Family and domain databases

Gene3D3.40.1050.10. 1 hit.
InterProIPR001765. Carbonic_anhydrase.
IPR015892. Carbonic_anhydrase_CS.
[Graphical view]
PANTHERPTHR11002. PTHR11002. 1 hit.
PfamPF00484. Pro_CA. 1 hit.
[Graphical view]
SMARTSM00947. Pro_CA. 1 hit.
[Graphical view]
SUPFAMSSF53056. SSF53056. 1 hit.
PROSITEPS00704. PROK_CO2_ANHYDRASE_1. 1 hit.
PS00705. PROK_CO2_ANHYDRASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP45148.

Entry information

Entry nameCAN_HAEIN
AccessionPrimary (citable) accession number: P45148
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names