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Protein

Pyruvate dehydrogenase E1 component

Gene

aceE

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.By similarity

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

GO - Molecular functioni

  1. pyruvate dehydrogenase (acetyl-transferring) activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Pyruvate, Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component (EC:1.2.4.1)
Short name:
PDH E1 component
Gene namesi
Name:aceE
Ordered Locus Names:HI_1233
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 886886Pyruvate dehydrogenase E1 componentPRO_0000162245Add
BLAST

Proteomic databases

PRIDEiP45119.

Interactioni

Subunit structurei

Homodimer. Part of the PDH complex, consisting of multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).By similarity

Protein-protein interaction databases

STRINGi71421.HI1233.

Structurei

3D structure databases

ProteinModelPortaliP45119.
SMRiP45119. Positions 57-886.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG2609.
KOiK00163.
OMAiEVIKVIW.
OrthoDBiEOG6BW4TW.
PhylomeDBiP45119.

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
3.40.50.970. 2 hits.
InterProiIPR004660. 2-oxoA_DH_E1.
IPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005474. Transketolase_N.
[Graphical view]
PfamiPF00456. Transketolase_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000156. Pyruvate_dh_E1. 1 hit.
SUPFAMiSSF52518. SSF52518. 2 hits.
SSF52922. SSF52922. 1 hit.
TIGRFAMsiTIGR00759. aceE. 1 hit.

Sequencei

Sequence statusi: Complete.

P45119-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSEILKNDVD PIETQDWLQS LDSLIREEGV ERAQYIVEQV IGQARTSGVS
60 70 80 90 100
LPTGVTTDYV NTIPVAEQPA YPGDHAIERR IRSAVRWNAI AMVLRSQKKD
110 120 130 140 150
LDLGGHISTF QSAATMYEVC YNHFFKAATE KNGGDLIFFQ GHAAPGMYAR
160 170 180 190 200
AFLEGRLTEE QMDNFRQEAF TDGLSSYPHP KLMPEFWQFS TVSMGLGPVN
210 220 230 240 250
AIYQARFLKY LDNRGLKDTK DQKVYAFLGD GEMDEIESKG ALTFAAREHL
260 270 280 290 300
DNLIFTISCN LQRLDGPVNG NGKIVQELEG LFTGAGWEVI KVLWGSDWDK
310 320 330 340 350
LFAKDTSGKL TQLMMEVVDG DYLTFKSKDG AYIREHFFGR YPETAALVAD
360 370 380 390 400
MTDDEIWALR RGAHDSEKLY AAYAKAQNAT KPVVILAHQV KGYKIPEAES
410 420 430 440 450
KNTAHQSKKM SYESLKGFRD FFELPLTDEQ VEKLEYIKFA EGTPEYEYLH
460 470 480 490 500
GHRKALNGYV PARRTKFDVE YKVPALEEFK ALLEEQPRGI STTMAFTRAL
510 520 530 540 550
NILLKDKNIG KTIVPMIADE ARTFGMEGLF RQVGIYNPHG QNYIPSDRDL
560 570 580 590 600
VAYYREAKDG QVLQEGINEL GATASWLAAA NSYSVNNQPM IPFFIYYSMF
610 620 630 640 650
GFQRVGDMMW AAGDQLARGF MVGGTSGRTT LNGEGLQHED GHSHIQAGII
660 670 680 690 700
PNCITYDPSF AFEVAVIMQD GINRMYGEKQ EDVFYYMTTL NEVMDQPAMP
710 720 730 740 750
AGAEEGIRKG LYKFETVEGK KGKGHVQLLG SGAIMRHVRE AAQILANDYG
760 770 780 790 800
VTSDVFSAPS FNELAREGHD AARWNLLHPT ETQRVPYVAQ VLADLPTVAS
810 820 830 840 850
TDYVKGYADQ IRAFVPSKHY HVLGTDGFGR SDSRANLREH FEVDARYVVV
860 870 880
AALSQLAKEG TVSNQVVADA IAKFGLNVDR INPLYA
Length:886
Mass (Da):99,131
Last modified:November 1, 1995 - v1
Checksum:i1B936A75DD69E71D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22886.1.
PIRiA64112.
RefSeqiNP_439389.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22886; AAC22886; HI_1233.
GeneIDi950116.
KEGGihin:HI1233.
PATRICi20191145. VBIHaeInf48452_1285.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22886.1.
PIRiA64112.
RefSeqiNP_439389.1. NC_000907.1.

3D structure databases

ProteinModelPortaliP45119.
SMRiP45119. Positions 57-886.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI1233.

Proteomic databases

PRIDEiP45119.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC22886; AAC22886; HI_1233.
GeneIDi950116.
KEGGihin:HI1233.
PATRICi20191145. VBIHaeInf48452_1285.

Phylogenomic databases

eggNOGiCOG2609.
KOiK00163.
OMAiEVIKVIW.
OrthoDBiEOG6BW4TW.
PhylomeDBiP45119.

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
3.40.50.970. 2 hits.
InterProiIPR004660. 2-oxoA_DH_E1.
IPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005474. Transketolase_N.
[Graphical view]
PfamiPF00456. Transketolase_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000156. Pyruvate_dh_E1. 1 hit.
SUPFAMiSSF52518. SSF52518. 2 hits.
SSF52922. SSF52922. 1 hit.
TIGRFAMsiTIGR00759. aceE. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiODP1_HAEIN
AccessioniPrimary (citable) accession number: P45119
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 4, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.