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P45119

- ODP1_HAEIN

UniProt

P45119 - ODP1_HAEIN

Protein

Pyruvate dehydrogenase E1 component

Gene

aceE

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.By similarity

    Catalytic activityi

    Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

    Cofactori

    Thiamine pyrophosphate.By similarity

    GO - Molecular functioni

    1. pyruvate dehydrogenase (acetyl-transferring) activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Pyruvate, Thiamine pyrophosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyruvate dehydrogenase E1 component (EC:1.2.4.1)
    Short name:
    PDH E1 component
    Gene namesi
    Name:aceE
    Ordered Locus Names:HI_1233
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 886886Pyruvate dehydrogenase E1 componentPRO_0000162245Add
    BLAST

    Proteomic databases

    PRIDEiP45119.

    Interactioni

    Subunit structurei

    Homodimer. Part of the PDH complex, consisting of multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).By similarity

    Protein-protein interaction databases

    STRINGi71421.HI1233.

    Structurei

    3D structure databases

    ProteinModelPortaliP45119.
    SMRiP45119. Positions 57-886.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG2609.
    KOiK00163.
    OMAiKGIYKLD.
    OrthoDBiEOG6BW4TW.
    PhylomeDBiP45119.

    Family and domain databases

    Gene3Di3.40.50.920. 1 hit.
    3.40.50.970. 2 hits.
    InterProiIPR004660. 2-oxoA_DH_E1.
    IPR029061. THDP-binding.
    IPR009014. Transketo_C/Pyr-ferredox_oxred.
    IPR005474. Transketolase_N.
    [Graphical view]
    PfamiPF00456. Transketolase_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000156. Pyruvate_dh_E1. 1 hit.
    SUPFAMiSSF52518. SSF52518. 2 hits.
    SSF52922. SSF52922. 1 hit.
    TIGRFAMsiTIGR00759. aceE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P45119-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEILKNDVD PIETQDWLQS LDSLIREEGV ERAQYIVEQV IGQARTSGVS    50
    LPTGVTTDYV NTIPVAEQPA YPGDHAIERR IRSAVRWNAI AMVLRSQKKD 100
    LDLGGHISTF QSAATMYEVC YNHFFKAATE KNGGDLIFFQ GHAAPGMYAR 150
    AFLEGRLTEE QMDNFRQEAF TDGLSSYPHP KLMPEFWQFS TVSMGLGPVN 200
    AIYQARFLKY LDNRGLKDTK DQKVYAFLGD GEMDEIESKG ALTFAAREHL 250
    DNLIFTISCN LQRLDGPVNG NGKIVQELEG LFTGAGWEVI KVLWGSDWDK 300
    LFAKDTSGKL TQLMMEVVDG DYLTFKSKDG AYIREHFFGR YPETAALVAD 350
    MTDDEIWALR RGAHDSEKLY AAYAKAQNAT KPVVILAHQV KGYKIPEAES 400
    KNTAHQSKKM SYESLKGFRD FFELPLTDEQ VEKLEYIKFA EGTPEYEYLH 450
    GHRKALNGYV PARRTKFDVE YKVPALEEFK ALLEEQPRGI STTMAFTRAL 500
    NILLKDKNIG KTIVPMIADE ARTFGMEGLF RQVGIYNPHG QNYIPSDRDL 550
    VAYYREAKDG QVLQEGINEL GATASWLAAA NSYSVNNQPM IPFFIYYSMF 600
    GFQRVGDMMW AAGDQLARGF MVGGTSGRTT LNGEGLQHED GHSHIQAGII 650
    PNCITYDPSF AFEVAVIMQD GINRMYGEKQ EDVFYYMTTL NEVMDQPAMP 700
    AGAEEGIRKG LYKFETVEGK KGKGHVQLLG SGAIMRHVRE AAQILANDYG 750
    VTSDVFSAPS FNELAREGHD AARWNLLHPT ETQRVPYVAQ VLADLPTVAS 800
    TDYVKGYADQ IRAFVPSKHY HVLGTDGFGR SDSRANLREH FEVDARYVVV 850
    AALSQLAKEG TVSNQVVADA IAKFGLNVDR INPLYA 886
    Length:886
    Mass (Da):99,131
    Last modified:November 1, 1995 - v1
    Checksum:i1B936A75DD69E71D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22886.1.
    PIRiA64112.
    RefSeqiNP_439389.1. NC_000907.1.
    WP_005694293.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC22886; AAC22886; HI_1233.
    GeneIDi950116.
    KEGGihin:HI1233.
    PATRICi20191145. VBIHaeInf48452_1285.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22886.1 .
    PIRi A64112.
    RefSeqi NP_439389.1. NC_000907.1.
    WP_005694293.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P45119.
    SMRi P45119. Positions 57-886.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI1233.

    Proteomic databases

    PRIDEi P45119.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC22886 ; AAC22886 ; HI_1233 .
    GeneIDi 950116.
    KEGGi hin:HI1233.
    PATRICi 20191145. VBIHaeInf48452_1285.

    Phylogenomic databases

    eggNOGi COG2609.
    KOi K00163.
    OMAi KGIYKLD.
    OrthoDBi EOG6BW4TW.
    PhylomeDBi P45119.

    Family and domain databases

    Gene3Di 3.40.50.920. 1 hit.
    3.40.50.970. 2 hits.
    InterProi IPR004660. 2-oxoA_DH_E1.
    IPR029061. THDP-binding.
    IPR009014. Transketo_C/Pyr-ferredox_oxred.
    IPR005474. Transketolase_N.
    [Graphical view ]
    Pfami PF00456. Transketolase_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000156. Pyruvate_dh_E1. 1 hit.
    SUPFAMi SSF52518. SSF52518. 2 hits.
    SSF52922. SSF52922. 1 hit.
    TIGRFAMsi TIGR00759. aceE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiODP1_HAEIN
    AccessioniPrimary (citable) accession number: P45119
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names

    External Data

    Dasty 3