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P45119

- ODP1_HAEIN

UniProt

P45119 - ODP1_HAEIN

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Protein
Pyruvate dehydrogenase E1 component
Gene
aceE, HI_1233
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2 By similarity.

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

Thiamine pyrophosphate By similarity.

GO - Molecular functioni

  1. pyruvate dehydrogenase (acetyl-transferring) activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Pyruvate, Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component (EC:1.2.4.1)
Short name:
PDH E1 component
Gene namesi
Name:aceE
Ordered Locus Names:HI_1233
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 886886Pyruvate dehydrogenase E1 component
PRO_0000162245Add
BLAST

Proteomic databases

PRIDEiP45119.

Interactioni

Subunit structurei

Homodimer By similarity. Part of the PDH complex, consisting of multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.

Protein-protein interaction databases

STRINGi71421.HI1233.

Structurei

3D structure databases

ProteinModelPortaliP45119.
SMRiP45119. Positions 57-886.

Family & Domainsi

Phylogenomic databases

eggNOGiCOG2609.
KOiK00163.
OMAiKGIYKLD.
OrthoDBiEOG6BW4TW.
PhylomeDBiP45119.

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
3.40.50.970. 2 hits.
InterProiIPR004660. 2-oxoA_DH_E1.
IPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005474. Transketolase_N.
[Graphical view]
PfamiPF00456. Transketolase_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000156. Pyruvate_dh_E1. 1 hit.
SUPFAMiSSF52518. SSF52518. 2 hits.
SSF52922. SSF52922. 1 hit.
TIGRFAMsiTIGR00759. aceE. 1 hit.

Sequencei

Sequence statusi: Complete.

P45119-1 [UniParc]FASTAAdd to Basket

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MSEILKNDVD PIETQDWLQS LDSLIREEGV ERAQYIVEQV IGQARTSGVS    50
LPTGVTTDYV NTIPVAEQPA YPGDHAIERR IRSAVRWNAI AMVLRSQKKD 100
LDLGGHISTF QSAATMYEVC YNHFFKAATE KNGGDLIFFQ GHAAPGMYAR 150
AFLEGRLTEE QMDNFRQEAF TDGLSSYPHP KLMPEFWQFS TVSMGLGPVN 200
AIYQARFLKY LDNRGLKDTK DQKVYAFLGD GEMDEIESKG ALTFAAREHL 250
DNLIFTISCN LQRLDGPVNG NGKIVQELEG LFTGAGWEVI KVLWGSDWDK 300
LFAKDTSGKL TQLMMEVVDG DYLTFKSKDG AYIREHFFGR YPETAALVAD 350
MTDDEIWALR RGAHDSEKLY AAYAKAQNAT KPVVILAHQV KGYKIPEAES 400
KNTAHQSKKM SYESLKGFRD FFELPLTDEQ VEKLEYIKFA EGTPEYEYLH 450
GHRKALNGYV PARRTKFDVE YKVPALEEFK ALLEEQPRGI STTMAFTRAL 500
NILLKDKNIG KTIVPMIADE ARTFGMEGLF RQVGIYNPHG QNYIPSDRDL 550
VAYYREAKDG QVLQEGINEL GATASWLAAA NSYSVNNQPM IPFFIYYSMF 600
GFQRVGDMMW AAGDQLARGF MVGGTSGRTT LNGEGLQHED GHSHIQAGII 650
PNCITYDPSF AFEVAVIMQD GINRMYGEKQ EDVFYYMTTL NEVMDQPAMP 700
AGAEEGIRKG LYKFETVEGK KGKGHVQLLG SGAIMRHVRE AAQILANDYG 750
VTSDVFSAPS FNELAREGHD AARWNLLHPT ETQRVPYVAQ VLADLPTVAS 800
TDYVKGYADQ IRAFVPSKHY HVLGTDGFGR SDSRANLREH FEVDARYVVV 850
AALSQLAKEG TVSNQVVADA IAKFGLNVDR INPLYA 886
Length:886
Mass (Da):99,131
Last modified:November 1, 1995 - v1
Checksum:i1B936A75DD69E71D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22886.1.
PIRiA64112.
RefSeqiNP_439389.1. NC_000907.1.
WP_005694293.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22886; AAC22886; HI_1233.
GeneIDi950116.
KEGGihin:HI1233.
PATRICi20191145. VBIHaeInf48452_1285.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22886.1 .
PIRi A64112.
RefSeqi NP_439389.1. NC_000907.1.
WP_005694293.1. NC_000907.1.

3D structure databases

ProteinModelPortali P45119.
SMRi P45119. Positions 57-886.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI1233.

Proteomic databases

PRIDEi P45119.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC22886 ; AAC22886 ; HI_1233 .
GeneIDi 950116.
KEGGi hin:HI1233.
PATRICi 20191145. VBIHaeInf48452_1285.

Phylogenomic databases

eggNOGi COG2609.
KOi K00163.
OMAi KGIYKLD.
OrthoDBi EOG6BW4TW.
PhylomeDBi P45119.

Family and domain databases

Gene3Di 3.40.50.920. 1 hit.
3.40.50.970. 2 hits.
InterProi IPR004660. 2-oxoA_DH_E1.
IPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005474. Transketolase_N.
[Graphical view ]
Pfami PF00456. Transketolase_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000156. Pyruvate_dh_E1. 1 hit.
SUPFAMi SSF52518. SSF52518. 2 hits.
SSF52922. SSF52922. 1 hit.
TIGRFAMsi TIGR00759. aceE. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiODP1_HAEIN
AccessioniPrimary (citable) accession number: P45119
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 3, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names

External Data

Dasty 3

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