Reviewed,
UniProtKB/Swiss-Prot P45118 (ODP2_HAEIN)
Last modified
February 9, 2010.
Version 75.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex EC=2.3.1.12 Alternative name(s): E2 Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex | ||||
| Gene names |
| ||||
| Organism | Haemophilus influenzae [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 727 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus |
Protein attributes
| Sequence length | 567 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity. |
| Catalytic activity | Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine. |
| Cofactor | Binds 2 lipoyl cofactors covalently By similarity. |
| Subunit structure | Forms a 24-polypeptide structural core with octahedral symmetry By similarity. |
| Sequence similarities | Belongs to the 2-oxoacid dehydrogenase family. Contains 2 lipoyl-binding domains. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Glycolysis |
| Domain | Lipoyl Repeat |
| Molecular function | Acyltransferase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | glycolysis Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | pyruvate dehydrogenase complex Inferred from electronic annotation. Source: InterPro |
| Molecular function | dihydrolipoyllysine-residue acetyltransferase activity Inferred from electronic annotation. Source: EC lipoic acid bindingInferred from electronic annotation. Source: UniProtKB-KW protein bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 567 | 567 | Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex | PRO_0000162279 | |||||
Regions | |||||||||
| Domain | 1 – 74 | 74 | Lipoyl-binding 1 | ||||||
| Domain | 109 – 180 | 72 | Lipoyl-binding 2 | ||||||
| Region | 247 – 567 | 321 | Subunit binding, catalytic | ||||||
Sites | |||||||||
| Active site | 484 | 1 | Potential | ||||||
| Active site | 540 | 1 | Potential | ||||||
| Active site | 544 | 1 | Potential | ||||||
Amino acid modifications | |||||||||
| Modified residue | 41 | 1 | N6-lipoyllysine By similarity | ||||||
| Modified residue | 147 | 1 | N6-lipoyllysine By similarity | ||||||
Sequences
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References
| [1] | "Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. Venter J.C.Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | L42023 Genomic DNA. Translation: AAC22885.1. |
| PIR | I64111. |
| RefSeq | NP_439388.1. |
3D structure databases | |
| SMR | P45118. Positions 1-80, 108-186, 257-298, 324-567. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 949836. |
| GenomeReviews | Gene locus HI1232 in contig L42023_GR. |
| KEGG | hin:HI1232. |
| NMPDR | fig|71421.1.peg.1178. |
| TIGR | HI1232. |
Phylogenomic databases | |
| HOGENOM | HBG630916. |
| OMA | GTYFTPL. |
Enzyme and pathway databases | |
| BioCyc | HINF71421:HI_1232-MONOMER. |
| BRENDA | 2.3.1.12. 109. |
Family and domain databases | |
| InterPro | IPR003016. 2-oxoA_DH_lipoyl-BS. IPR001078. 2-oxoacid_DH_actylTfrase. IPR006256. AcTrfase_Pyrv_DH_cplx. IPR000089. Biotin_lipoyl. IPR004167. E3_bd. IPR011053. Single_hybrid_motif. [Graphical view] |
| Gene3D | G3DSA:4.10.320.10. E3_bd. 1 hit. |
| Pfam | PF00198. 2-oxoacid_dh. 1 hit. PF00364. Biotin_lipoyl. 2 hits. PF02817. E3_binding. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01348. PDHac_trf_long. 1 hit. |
| PROSITE | PS50968. BIOTINYL_LIPOYL. 2 hits. PS00189. LIPOYL. 2 hits. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ODP2_HAEIN | ||||||||
| Accession | Primary (citable) accession number: P45118 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Haemophilus influenzae Haemophilus influenzae (strain Rd): entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with


