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P45118

- ODP2_HAEIN

UniProt

P45118 - ODP2_HAEIN

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Protein
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
Gene
aceF, HI_1232
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.

Catalytic activityi

Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.

Cofactori

Binds 2 lipoyl cofactors covalently By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei484 – 4841 Reviewed prediction
Active sitei540 – 5401 Reviewed prediction
Active sitei544 – 5441 Reviewed prediction

GO - Molecular functioni

  1. dihydrolipoyllysine-residue acetyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Glycolysis

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex (EC:2.3.1.12)
Alternative name(s):
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
E2
Gene namesi
Name:aceF
Ordered Locus Names:HI_1232
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. pyruvate dehydrogenase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 567567Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
PRO_0000162279Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei41 – 411N6-lipoyllysine By similarity
Modified residuei147 – 1471N6-lipoyllysine By similarity

Proteomic databases

PRIDEiP45118.

Interactioni

Subunit structurei

Forms a 24-polypeptide structural core with octahedral symmetry By similarity.

Protein-protein interaction databases

STRINGi71421.HI1232.

Structurei

3D structure databases

ProteinModelPortaliP45118.
SMRiP45118. Positions 1-80, 108-186, 324-567.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 7474Lipoyl-binding 1
Add
BLAST
Domaini109 – 18072Lipoyl-binding 2
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni247 – 567321Subunit binding, catalytic
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Lipoyl, Repeat

Phylogenomic databases

eggNOGiCOG0508.
KOiK00627.
OMAiTEIMVAV.
OrthoDBiEOG610413.
PhylomeDBiP45118.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR006256. AcTrfase_Pyrv_DH_cplx.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 2 hits.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 2 hits.
TIGRFAMsiTIGR01348. PDHac_trf_long. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 2 hits.
PS00189. LIPOYL. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P45118-1 [UniParc]FASTAAdd to Basket

« Hide

MSKQIQIPDI GSDEVTVTEV MVNVGDTISV DQSIINVEGD KASMEVPAPE    50
AGVVKEILVK VGDKVSTGTP MLVLEAAGAA PAADEPTAPV ADAPTAPVVA 100
TAPTASAIVE VNVPDIGGDE VNVTEIMVAV GDTITEEQSL ITVEGDKASM 150
EVPAPFGGVV KEILVKSGDK VSTGSLIMRF EVLGAAPAES ASAPASTSAP 200
QTAAPATTAQ APQAAAPDTT AQAPQAAAPD TTAQAAQSNN NVSGLSQEQV 250
EASTGYAHAT PVIRRLAREF GVNLDKVKGT GRKGRIVKED IEAYVKTAVK 300
AYESGATAQA TGNGVANGAG LGLLPWPKVD FSKFGEIEEV ELSRINKISG 350
ANLHRNWVII PHVTHFDKAD ITDLEAFRKE QNALREKQKL GVKITPVVFI 400
MKAVAKALEA YPRFNSSITE DAQRLILKKY INIGVAVDTP NGLVVPVFKN 450
VNKKGIIELS RELMEVSKKA REGKLTASDM QGGCFTISSL GGIGTTHFAP 500
IVNAPEVAIL GVSKSSMEPV WNGKEFAPRL ILPMSLSFDH RVIDGADGAR 550
FISYLGSVLA DLRRLVM 567
Length:567
Mass (Da):59,411
Last modified:November 1, 1995 - v1
Checksum:i891DBCDEB388C5B0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22885.1.
PIRiI64111.
RefSeqiNP_439388.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22885; AAC22885; HI_1232.
GeneIDi949836.
KEGGihin:HI1232.
PATRICi20191143. VBIHaeInf48452_1284.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22885.1 .
PIRi I64111.
RefSeqi NP_439388.1. NC_000907.1.

3D structure databases

ProteinModelPortali P45118.
SMRi P45118. Positions 1-80, 108-186, 324-567.
ModBasei Search...

Protein-protein interaction databases

STRINGi 71421.HI1232.

Proteomic databases

PRIDEi P45118.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC22885 ; AAC22885 ; HI_1232 .
GeneIDi 949836.
KEGGi hin:HI1232.
PATRICi 20191143. VBIHaeInf48452_1284.

Phylogenomic databases

eggNOGi COG0508.
KOi K00627.
OMAi TEIMVAV.
OrthoDBi EOG610413.
PhylomeDBi P45118.

Family and domain databases

Gene3Di 3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProi IPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR006256. AcTrfase_Pyrv_DH_cplx.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR011053. Single_hybrid_motif.
[Graphical view ]
Pfami PF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 2 hits.
PF02817. E3_binding. 1 hit.
[Graphical view ]
SUPFAMi SSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 2 hits.
TIGRFAMsi TIGR01348. PDHac_trf_long. 1 hit.
PROSITEi PS50968. BIOTINYL_LIPOYL. 2 hits.
PS00189. LIPOYL. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiODP2_HAEIN
AccessioniPrimary (citable) accession number: P45118
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi