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Protein

Thiol:disulfide interchange protein DsbC

Gene

dsbC

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbC is reoxidized by a yet uncharacterized protein. Also acts as a disulfide isomerase (By similarity).By similarity

Enzyme and pathway databases

BioCyciHINF71421:G1GJ1-1244-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Thiol:disulfide interchange protein DsbC
Gene namesi
Name:dsbC
Synonyms:xprA
Ordered Locus Names:HI_1213
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18By similarityAdd BLAST18
ChainiPRO_000003427619 – 229Thiol:disulfide interchange protein DsbCAdd BLAST211

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi116 ↔ 119Redox-active1 Publication

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi71421.HI1213

Structurei

Secondary structure

1229
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni21 – 23Combined sources3
Helixi24 – 28Combined sources5
Turni29 – 31Combined sources3
Beta strandi56 – 62Combined sources7
Turni73 – 75Combined sources3
Helixi81 – 90Combined sources10
Helixi91 – 95Combined sources5
Beta strandi96 – 99Combined sources4
Beta strandi105 – 112Combined sources8
Helixi117 – 123Combined sources7
Helixi126 – 131Combined sources6
Beta strandi134 – 140Combined sources7
Helixi149 – 159Combined sources11
Beta strandi160 – 162Combined sources3
Helixi163 – 171Combined sources9
Helixi184 – 195Combined sources12
Beta strandi202 – 204Combined sources3
Helixi217 – 226Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1T3BX-ray2.50A19-229[»]
ProteinModelPortaliP45111
SMRiP45111
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP45111

Family & Domainsi

Sequence similaritiesi

Belongs to the thioredoxin family. DsbC subfamily.Curated

Keywords - Domaini

Redox-active center, Signal

Phylogenomic databases

eggNOGiENOG4105T95 Bacteria
COG1651 LUCA
KOiK03981
OMAiQMIVYKA
PhylomeDBiP45111

Family and domain databases

CDDicd03020 DsbA_DsbC_DsbG, 1 hit
Gene3Di3.10.450.70, 1 hit
InterProiView protein in InterPro
IPR033954 DiS-bond_Isoase_DsbC/G
IPR018950 DiS-bond_isomerase_DsbC/G_N
IPR009094 DiS-bond_isomerase_DsbC/G_N_sf
IPR012336 Thioredoxin-like_fold
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF10411 DsbC_N, 1 hit
PF13098 Thioredoxin_2, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
SSF54423 SSF54423, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P45111-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKIFTALLC VAAANAMADD AAIKRKLQSF NISNIVIKSS PISGIKTAVT
60 70 80 90 100
DQGILYVSED GKYLFEGKLY ELTNNGPVDV AGKILVDKLN SYKDEMIVYP
110 120 130 140 150
AKNEKHVVTV FMDITCHYCH LLHQQLKEYN DLGITVRYLA FPRAGMNNQT
160 170 180 190 200
AKQMEAIWTA KDPVFALNEA EKGNLPKEVK TPNIVKKHYE LGIQFGVRGT
210 220
PSIVTSTGEL IGGYLKPADL LRALEETAQ
Length:229
Mass (Da):25,351
Last modified:November 1, 1995 - v1
Checksum:iAF0F08AFC0FD08E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA Translation: AAC22866.1
PIRiE64110
RefSeqiNP_439369.1, NC_000907.1
WP_005647404.1, NC_000907.1

Genome annotation databases

EnsemblBacteriaiAAC22866; AAC22866; HI_1213
GeneIDi950655
KEGGihin:HI1213
PATRICifig|71421.8.peg.1265

Similar proteinsi

Entry informationi

Entry nameiDSBC_HAEIN
AccessioniPrimary (citable) accession number: P45111
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 25, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health