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P45107 (PTA_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphate acetyltransferase

EC=2.3.1.8
Alternative name(s):
Phosphotransacetylase
Gene names
Name:pta
Ordered Locus Names:HI_1203
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length711 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in acetate metabolism By similarity.

Catalytic activity

Acetyl-CoA + phosphate = CoA + acetyl phosphate.

Pathway

Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 2/2.

Subunit structure

Homohexamer By similarity.

Subcellular location

Cytoplasm Potential.

Domain

The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site By similarity.

Sequence similarities

In the N-terminal section; belongs to the CobB/CobQ family.

In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionAcyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processacetyl-CoA biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionphosphate acetyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 711711Phosphate acetyltransferase
PRO_0000179130

Regions

Region390 – 711322Phosphate acetyltransferase

Sequences

Sequence LengthMass (Da)Tools
P45107 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 4C684C943E2870CB

FASTA71176,517
        10         20         30         40         50         60 
MSRTIILIPV STGVGLTSIS LGLIHSLEQK GTKVAFMKPV SQPSTGEDKL DRTTSIIRTS 

        70         80         90        100        110        120 
TSLETAEPFM LSVAESLIGQ NQSDVLLEKI VANHQQLTKN NDIVVVEGLI PTRKHGYANS 

       130        140        150        160        170        180 
INYEIAQALD AEIVLVAAPA TETPTELKDR VEAAASLFGG KNNPNLLGVV VNKFNAPVDE 

       190        200        210        220        230        240 
SGRTRPDLAE IFDSFQHNHI SETEVNKLFA GSAIKLLACV PWNANLIATR AIDLVKHLGA 

       250        260        270        280        290        300 
SIINEGEINR RIRGITFCAR SLPNMVEHFR AGSLLVASAD RPDVLVAAAL AASNGIEIGG 

       310        320        330        340        350        360 
ILLTGGYKID AQINKLCRPT FEKAKLPIFR IEGNTWQTAL SLQSFNLEVP VDDKERIENI 

       370        380        390        400        410        420 
KQYISQHFNA DFINNLVADS SRLPRLSPPA FRFQLTELAR AAKKRIVLPE GDEPRTIKAA 

       430        440        450        460        470        480 
VLCAERGIAE CVLLADPASV QRVAEAQGVK LGKGITIINP ADVRENYVDR LVELRKAKGM 

       490        500        510        520        530        540 
TETAAREQLE DTVVLGTMML EANEVDGLVS GAVHTTANTI RPPMQIIKTA PGSSIVSSIF 

       550        560        570        580        590        600 
FMLLPDQVLV YGDCAVNPDP TAEQLAEIAI QSADSAKAFG IDPKVAMISY STGTSGSGAD 

       610        620        630        640        650        660 
VEKVKEATRI AKEKRPDLLI DGPLQYDAAV MEDVARSKAP NSPVAGKATV FVFPDLNTGN 

       670        680        690        700        710 
TTYKAVQRSA DLVSIGPMLQ GMRKPVNDLS RGALVDDIVY TIALTAIQAT Q 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC22857.1.
PIRB64169.
RefSeqNP_439359.1. NC_000907.1.

3D structure databases

ProteinModelPortalP45107.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI1203.

Proteomic databases

PRIDEP45107.

Protocols and materials databases

DNASU950151.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC22857; AAC22857; HI_1203.
GeneID950151.
KEGGhin:HI1203.
PATRIC20191085. VBIHaeInf48452_1255.

Phylogenomic databases

eggNOGCOG0280.
KOK13788.
OMAKPIAQPH.
OrthoDBEOG6BKJ5W.
PhylomeDBP45107.

Enzyme and pathway databases

UniPathwayUPA00340; UER00459.

Family and domain databases

Gene3D3.40.1390.20. 1 hit.
3.40.50.300. 1 hit.
InterProIPR010766. DRTGG.
IPR016475. P-Actrans_bac.
IPR027417. P-loop_NTPase.
IPR004614. P_AcTrfase.
IPR002505. PTA_PTB.
IPR028979. Ser_kin/Pase_Hpr_N_like.
[Graphical view]
PfamPF07085. DRTGG. 1 hit.
PF01515. PTA_PTB. 1 hit.
[Graphical view]
PIRSFPIRSF006107. PhpActrans_proteobac. 1 hit.
SUPFAMSSF52540. SSF52540. 1 hit.
SSF75138. SSF75138. 1 hit.
TIGRFAMsTIGR00651. pta. 1 hit.
ProtoNetSearch...

Entry information

Entry namePTA_HAEIN
AccessionPrimary (citable) accession number: P45107
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names