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P45107

- PTA_HAEIN

UniProt

P45107 - PTA_HAEIN

Protein

Phosphate acetyltransferase

Gene

pta

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Involved in acetate metabolism.By similarity

    Catalytic activityi

    Acetyl-CoA + phosphate = CoA + acetyl phosphate.

    Pathwayi

    GO - Molecular functioni

    1. phosphate acetyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. acetyl-CoA biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Enzyme and pathway databases

    UniPathwayiUPA00340; UER00459.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphate acetyltransferase (EC:2.3.1.8)
    Alternative name(s):
    Phosphotransacetylase
    Gene namesi
    Name:pta
    Ordered Locus Names:HI_1203
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 711711Phosphate acetyltransferasePRO_0000179130Add
    BLAST

    Proteomic databases

    PRIDEiP45107.

    Interactioni

    Subunit structurei

    Homohexamer.By similarity

    Protein-protein interaction databases

    STRINGi71421.HI1203.

    Structurei

    3D structure databases

    ProteinModelPortaliP45107.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni390 – 711322Phosphate acetyltransferaseAdd
    BLAST

    Domaini

    The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site By similarity.By similarity

    Sequence similaritiesi

    In the N-terminal section; belongs to the CobB/CobQ family.Curated
    In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.Curated

    Phylogenomic databases

    eggNOGiCOG0280.
    KOiK13788.
    OMAiKPIAQPH.
    OrthoDBiEOG6BKJ5W.
    PhylomeDBiP45107.

    Family and domain databases

    Gene3Di3.40.1390.20. 1 hit.
    3.40.50.300. 1 hit.
    InterProiIPR010766. DRTGG.
    IPR016475. P-Actrans_bac.
    IPR027417. P-loop_NTPase.
    IPR004614. P_AcTrfase.
    IPR002505. PTA_PTB.
    IPR028979. Ser_kin/Pase_Hpr_N_like.
    [Graphical view]
    PfamiPF07085. DRTGG. 1 hit.
    PF01515. PTA_PTB. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006107. PhpActrans_proteobac. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    SSF75138. SSF75138. 1 hit.
    TIGRFAMsiTIGR00651. pta. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P45107-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRTIILIPV STGVGLTSIS LGLIHSLEQK GTKVAFMKPV SQPSTGEDKL    50
    DRTTSIIRTS TSLETAEPFM LSVAESLIGQ NQSDVLLEKI VANHQQLTKN 100
    NDIVVVEGLI PTRKHGYANS INYEIAQALD AEIVLVAAPA TETPTELKDR 150
    VEAAASLFGG KNNPNLLGVV VNKFNAPVDE SGRTRPDLAE IFDSFQHNHI 200
    SETEVNKLFA GSAIKLLACV PWNANLIATR AIDLVKHLGA SIINEGEINR 250
    RIRGITFCAR SLPNMVEHFR AGSLLVASAD RPDVLVAAAL AASNGIEIGG 300
    ILLTGGYKID AQINKLCRPT FEKAKLPIFR IEGNTWQTAL SLQSFNLEVP 350
    VDDKERIENI KQYISQHFNA DFINNLVADS SRLPRLSPPA FRFQLTELAR 400
    AAKKRIVLPE GDEPRTIKAA VLCAERGIAE CVLLADPASV QRVAEAQGVK 450
    LGKGITIINP ADVRENYVDR LVELRKAKGM TETAAREQLE DTVVLGTMML 500
    EANEVDGLVS GAVHTTANTI RPPMQIIKTA PGSSIVSSIF FMLLPDQVLV 550
    YGDCAVNPDP TAEQLAEIAI QSADSAKAFG IDPKVAMISY STGTSGSGAD 600
    VEKVKEATRI AKEKRPDLLI DGPLQYDAAV MEDVARSKAP NSPVAGKATV 650
    FVFPDLNTGN TTYKAVQRSA DLVSIGPMLQ GMRKPVNDLS RGALVDDIVY 700
    TIALTAIQAT Q 711
    Length:711
    Mass (Da):76,517
    Last modified:January 23, 2007 - v2
    Checksum:i4C684C943E2870CB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22857.1.
    PIRiB64169.
    RefSeqiNP_439359.1. NC_000907.1.
    WP_005694242.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC22857; AAC22857; HI_1203.
    GeneIDi950151.
    KEGGihin:HI1203.
    PATRICi20191085. VBIHaeInf48452_1255.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22857.1 .
    PIRi B64169.
    RefSeqi NP_439359.1. NC_000907.1.
    WP_005694242.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P45107.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI1203.

    Proteomic databases

    PRIDEi P45107.

    Protocols and materials databases

    DNASUi 950151.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC22857 ; AAC22857 ; HI_1203 .
    GeneIDi 950151.
    KEGGi hin:HI1203.
    PATRICi 20191085. VBIHaeInf48452_1255.

    Phylogenomic databases

    eggNOGi COG0280.
    KOi K13788.
    OMAi KPIAQPH.
    OrthoDBi EOG6BKJ5W.
    PhylomeDBi P45107.

    Enzyme and pathway databases

    UniPathwayi UPA00340 ; UER00459 .

    Family and domain databases

    Gene3Di 3.40.1390.20. 1 hit.
    3.40.50.300. 1 hit.
    InterProi IPR010766. DRTGG.
    IPR016475. P-Actrans_bac.
    IPR027417. P-loop_NTPase.
    IPR004614. P_AcTrfase.
    IPR002505. PTA_PTB.
    IPR028979. Ser_kin/Pase_Hpr_N_like.
    [Graphical view ]
    Pfami PF07085. DRTGG. 1 hit.
    PF01515. PTA_PTB. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006107. PhpActrans_proteobac. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    SSF75138. SSF75138. 1 hit.
    TIGRFAMsi TIGR00651. pta. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiPTA_HAEIN
    AccessioniPrimary (citable) accession number: P45107
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 101 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3