P45095 (DPPD_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dipeptide transport ATP-binding protein DppD

Gene names

Name:	dppD
Ordered Locus Names:	HI_1185

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]

Taxonomic identifier

71421 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus › Haemophilus influenzae

Protein attributes

Sequence length	330 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Part of the binding-protein-dependent transport system for dipeptides. Probably responsible for energy coupling to the transport system By similarity.
Subcellular location	Cell inner membrane; Peripheral membrane protein Potential.
Sequence similarities	Belongs to the ABC transporter superfamily. Contains 1 ABC transporter domain.

Ontologies

Keywords
Biological process	Peptide transport Protein transport Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ATP catabolic process Inferred from electronic annotation. Source: GOC protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity Inferred from electronic annotation. Source: InterPro peptide transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 330	330	Dipeptide transport ATP-binding protein DppD		PRO_0000092315
Regions
	Domain	6 – 254	249	ABC transporter
	Nucleotide binding	40 – 47	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	P45095 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 964801E58D5656DE	FASTA	330	36,328
	10 20 30 40 50 60 MALLDVKELS VHFGDKKTPF KAVDRISYQV AQGEVLGIVG ESGSGKSVSS LAIMGLIDHP 70 80 90 100 110 120 GRVSAESLQF ENTDLLTLES KAKRQLIGAD VAMIFQDPMT SLNPAYTVGF QIMEALKTHE 130 140 150 160 170 180 GGTKKARKDR TLELLKLVGI PDPESRIDVY PHQLSGGMSQ RVMIAMAIAC RPKLLIADEP 190 200 210 220 230 240 TTALDVTIQA QIMELLLELQ KKECMSLILI THDLALVAEA AERIIVMYAG QIVEEGTAKD 250 260 270 280 290 300 IFREPKHPYT QALLRSLPEF AEGKSRLESL QGVVPGKYDR PTGCLLNPRC PYATEYCRQV 310 320 330 EPQLHHIGSR KVKCHTPLNE QGNPVEYQGA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
[2]	"Altered lipopolysaccharide characteristic of the I69 phenotype in Haemophilus influenzae results from mutations in a novel gene, isn." Preston A., Maskell D., Johnson A., Moxon E.R. J. Bacteriol. 178:396-402(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L42023 Genomic DNA. Translation: AAC22838.1. U17295 Genomic DNA. Translation: AAA95974.1.
PIR	F64188.
RefSeq	NP_439341.1. NC_000907.1.
3D structure databases
ProteinModelPortal	P45095.
ModBase	Search...
Protein-protein interaction databases
STRING	71421.HI1185.
Protein family/group databases
TCDB	3.A.1.5.27. ATP-binding cassette (ABC) superfamily.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC22838; AAC22838; HI_1185.
GeneID	950137.
KEGG	hin:HI1185.
PATRIC	20191047. VBIHaeInf48452_1236.
Phylogenomic databases
eggNOG	COG0444.
KO	K12371.
OMA	CRRQRPP.
ProtClustDB	PRK11022.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR010066. Oligo_ATP-bd_C. IPR013563. Oligopep_ABC_C. IPR027417. P-loop_NTPase. [Graphical view]
Pfam	PF00005. ABC_tran. 1 hit. PF08352. oligo_HPY. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
SUPFAM	SSF52540. SSF52540. 1 hit.
TIGRFAMs	TIGR01727. oligo_HPY. 1 hit.
PROSITE	PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DPPD_HAEIN

Accession

Primary (citable) accession number: P45095

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	May 29, 2013
This is version 97 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program