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P45078

- HPRT_HAEIN

UniProt

P45078 - HPRT_HAEIN

Protein

Hypoxanthine phosphoribosyltransferase

Gene

hpt

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Acts preferentially on hypoxanthine; has very low activity towards guanine. Inactive towards xanthine By similarity.By similarity

    Catalytic activityi

    IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.

    Cofactori

    Binds 2 magnesium ions per subunit. The magnesium ions are essentially bound to the substrate and have few direct interactions with the protein By similarity.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei105 – 1051Proton acceptorBy similarity
    Binding sitei133 – 1331IMPBy similarity
    Binding sitei155 – 1551IMP; via carbonyl oxygenBy similarity
    Metal bindingi161 – 1611MagnesiumBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi101 – 11010IMPBy similarity
    Nucleotide bindingi160 – 1612IMPBy similarity

    GO - Molecular functioni

    1. guanine phosphoribosyltransferase activity Source: UniProtKB-EC
    2. hypoxanthine phosphoribosyltransferase activity Source: UniProtKB-EC
    3. metal ion binding Source: UniProtKB-KW
    4. nucleotide binding Source: UniProtKB-KW

    GO - Biological processi

    1. IMP salvage Source: UniProtKB-UniPathway
    2. purine ribonucleoside salvage Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Purine salvage

    Keywords - Ligandi

    Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00591; UER00648.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hypoxanthine phosphoribosyltransferase (EC:2.4.2.8)
    Short name:
    HPRT
    Gene namesi
    Name:hpt
    Ordered Locus Names:HI_1153
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 179179Hypoxanthine phosphoribosyltransferasePRO_0000139634Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.

    Protein-protein interaction databases

    STRINGi71421.HI1153.

    Structurei

    3D structure databases

    ProteinModelPortaliP45078.
    SMRiP45078. Positions 3-177.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0634.
    KOiK00760.
    OMAiVDFMTVS.
    OrthoDBiEOG693GNP.
    PhylomeDBiP45078.

    Family and domain databases

    Gene3Di3.40.50.2020. 1 hit.
    InterProiIPR005904. Hxn_phspho_trans.
    IPR000836. PRibTrfase_dom.
    IPR029057. PRTase-like.
    [Graphical view]
    PfamiPF00156. Pribosyltran. 1 hit.
    [Graphical view]
    SUPFAMiSSF53271. SSF53271. 1 hit.
    TIGRFAMsiTIGR01203. HGPRTase. 1 hit.
    PROSITEiPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P45078-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKHHVDVLI SENDVHARIA ELGAQITKFY QEKQIDNLVV VGLLRGSFMF    50
    MADIVRQINL PVEIEFMTTS SYGTGMTTNH DVRITKDLDG DIKGKHVLIV 100
    EDIIDTGYTL EKVRDILNLR EPASLTICTL LDKPSRREVE VPVEWVGFEI 150
    PDEFVVGYGI DYAQRHRNLG YIGKVVLEE 179
    Length:179
    Mass (Da):20,370
    Last modified:November 1, 1995 - v1
    Checksum:i65F8C1314942BFE7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22808.1.
    PIRiD64168.
    RefSeqiNP_439311.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC22808; AAC22808; HI_1153.
    GeneIDi950117.
    KEGGihin:HI1153.
    PATRICi20190981. VBIHaeInf48452_1203.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22808.1 .
    PIRi D64168.
    RefSeqi NP_439311.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P45078.
    SMRi P45078. Positions 3-177.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI1153.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC22808 ; AAC22808 ; HI_1153 .
    GeneIDi 950117.
    KEGGi hin:HI1153.
    PATRICi 20190981. VBIHaeInf48452_1203.

    Phylogenomic databases

    eggNOGi COG0634.
    KOi K00760.
    OMAi VDFMTVS.
    OrthoDBi EOG693GNP.
    PhylomeDBi P45078.

    Enzyme and pathway databases

    UniPathwayi UPA00591 ; UER00648 .

    Family and domain databases

    Gene3Di 3.40.50.2020. 1 hit.
    InterProi IPR005904. Hxn_phspho_trans.
    IPR000836. PRibTrfase_dom.
    IPR029057. PRTase-like.
    [Graphical view ]
    Pfami PF00156. Pribosyltran. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53271. SSF53271. 1 hit.
    TIGRFAMsi TIGR01203. HGPRTase. 1 hit.
    PROSITEi PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiHPRT_HAEIN
    AccessioniPrimary (citable) accession number: P45078
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3