Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P45078 (HPRT_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hypoxanthine phosphoribosyltransferase

Short name=HPRT
EC=2.4.2.8
Gene names
Name:hpt
Ordered Locus Names:HI_1153
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length179 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Acts preferentially on hypoxanthine; has very low activity towards guanine. Inactive towards xanthine By similarity.

Catalytic activity

IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.

Cofactor

Binds 2 magnesium ions per subunit. The magnesium ions are essentially bound to the substrate and have few direct interactions with the protein By similarity.

Pathway

Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.

Subunit structure

Homotetramer.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 179179Hypoxanthine phosphoribosyltransferase
PRO_0000139634

Regions

Nucleotide binding101 – 11010IMP By similarity
Nucleotide binding160 – 1612IMP By similarity

Sites

Active site1051Proton acceptor By similarity
Metal binding1611Magnesium By similarity
Binding site1331IMP By similarity
Binding site1551IMP; via carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
P45078 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 65F8C1314942BFE7

FASTA17920,370
        10         20         30         40         50         60 
MKKHHVDVLI SENDVHARIA ELGAQITKFY QEKQIDNLVV VGLLRGSFMF MADIVRQINL 

        70         80         90        100        110        120 
PVEIEFMTTS SYGTGMTTNH DVRITKDLDG DIKGKHVLIV EDIIDTGYTL EKVRDILNLR 

       130        140        150        160        170 
EPASLTICTL LDKPSRREVE VPVEWVGFEI PDEFVVGYGI DYAQRHRNLG YIGKVVLEE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC22808.1.
PIRD64168.
RefSeqNP_439311.1. NC_000907.1.

3D structure databases

ProteinModelPortalP45078.
SMRP45078. Positions 3-177.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI1153.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC22808; AAC22808; HI_1153.
GeneID950117.
KEGGhin:HI1153.
PATRIC20190981. VBIHaeInf48452_1203.

Phylogenomic databases

eggNOGCOG0634.
KOK00760.
OMAVDFMTVS.
OrthoDBEOG693GNP.
PhylomeDBP45078.

Enzyme and pathway databases

UniPathwayUPA00591; UER00648.

Family and domain databases

Gene3D3.40.50.2020. 1 hit.
InterProIPR005904. Hxn_phspho_trans.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMSSF53271. SSF53271. 1 hit.
TIGRFAMsTIGR01203. HGPRTase. 1 hit.
PROSITEPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHPRT_HAEIN
AccessionPrimary (citable) accession number: P45078
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names