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Protein

Hypoxanthine phosphoribosyltransferase

Gene

hpt

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Acts preferentially on hypoxanthine; has very low activity towards guanine. Inactive towards xanthine (By similarity).By similarity

Catalytic activityi

IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.

Cofactori

Mg2+By similarityNote: Binds 2 magnesium ions per subunit. The magnesium ions are essentially bound to the substrate and have few direct interactions with the protein.By similarity

Pathwayi: IMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes IMP from hypoxanthine.
Proteins known to be involved in this subpathway in this organism are:
  1. Hypoxanthine phosphoribosyltransferase (hpt)
This subpathway is part of the pathway IMP biosynthesis via salvage pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes IMP from hypoxanthine, the pathway IMP biosynthesis via salvage pathway and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei105Proton acceptorBy similarity1
Binding sitei133IMPBy similarity1
Binding sitei155IMP; via carbonyl oxygenBy similarity1
Metal bindingi161MagnesiumBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi101 – 110IMPBy similarity10
Nucleotide bindingi160 – 161IMPBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processPurine salvage
LigandMagnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHINF71421:G1GJ1-1186-MONOMER
UniPathwayiUPA00591; UER00648

Names & Taxonomyi

Protein namesi
Recommended name:
Hypoxanthine phosphoribosyltransferase (EC:2.4.2.8)
Short name:
HPRT
Gene namesi
Name:hpt
Ordered Locus Names:HI_1153
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001396341 – 179Hypoxanthine phosphoribosyltransferaseAdd BLAST179

Proteomic databases

PRIDEiP45078

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

STRINGi71421.HI1153

Structurei

3D structure databases

ProteinModelPortaliP45078
SMRiP45078
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108UGV Bacteria
COG0634 LUCA
KOiK00760
OMAiTMDWMAV
PhylomeDBiP45078

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
InterProiView protein in InterPro
IPR005904 Hxn_phspho_trans
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
PfamiView protein in Pfam
PF00156 Pribosyltran, 1 hit
SUPFAMiSSF53271 SSF53271, 1 hit
TIGRFAMsiTIGR01203 HGPRTase, 1 hit
PROSITEiView protein in PROSITE
PS00103 PUR_PYR_PR_TRANSFER, 1 hit

Sequencei

Sequence statusi: Complete.

P45078-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKHHVDVLI SENDVHARIA ELGAQITKFY QEKQIDNLVV VGLLRGSFMF
60 70 80 90 100
MADIVRQINL PVEIEFMTTS SYGTGMTTNH DVRITKDLDG DIKGKHVLIV
110 120 130 140 150
EDIIDTGYTL EKVRDILNLR EPASLTICTL LDKPSRREVE VPVEWVGFEI
160 170
PDEFVVGYGI DYAQRHRNLG YIGKVVLEE
Length:179
Mass (Da):20,370
Last modified:November 1, 1995 - v1
Checksum:i65F8C1314942BFE7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA Translation: AAC22808.1
PIRiD64168
RefSeqiNP_439311.1, NC_000907.1
WP_005693468.1, NC_000907.1

Genome annotation databases

EnsemblBacteriaiAAC22808; AAC22808; HI_1153
GeneIDi950117
KEGGihin:HI1153
PATRICifig|71421.8.peg.1203

Similar proteinsi

Entry informationi

Entry nameiHPRT_HAEIN
AccessioniPrimary (citable) accession number: P45078
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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