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Protein

UDP-N-acetylmuramate--L-alanine ligase

Gene

murC

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cell wall formation.

Catalytic activityi

ATP + UDP-N-acetyl-alpha-D-muramate + L-alanine = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine.

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi125 – 131ATPSequence analysis7

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi6.3.2.8. 2529.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylmuramate--L-alanine ligase (EC:6.3.2.8)
Alternative name(s):
UDP-N-acetylmuramoyl-L-alanine synthetase
Gene namesi
Name:murC
Ordered Locus Names:HI_1139
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001821001 – 475UDP-N-acetylmuramate--L-alanine ligaseAdd BLAST475

Interactioni

Protein-protein interaction databases

STRINGi71421.HI1139.

Structurei

Secondary structure

1475
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 9Combined sources7
Beta strandi20 – 25Combined sources6
Helixi31 – 41Combined sources11
Beta strandi44 – 50Combined sources7
Helixi54 – 61Combined sources8
Beta strandi65 – 69Combined sources5
Helixi72 – 75Combined sources4
Beta strandi79 – 83Combined sources5
Beta strandi85 – 87Combined sources3
Helixi92 – 99Combined sources8
Beta strandi104 – 106Combined sources3
Helixi107 – 116Combined sources10
Beta strandi118 – 127Combined sources10
Helixi129 – 142Combined sources14
Beta strandi148 – 150Combined sources3
Turni156 – 158Combined sources3
Beta strandi159 – 163Combined sources5
Beta strandi166 – 173Combined sources8
Helixi180 – 183Combined sources4
Beta strandi187 – 191Combined sources5
Helixi199 – 202Combined sources4
Helixi206 – 217Combined sources12
Beta strandi225 – 229Combined sources5
Helixi233 – 242Combined sources10
Beta strandi244 – 252Combined sources9
Beta strandi256 – 265Combined sources10
Beta strandi268 – 274Combined sources7
Beta strandi280 – 287Combined sources8
Helixi290 – 305Combined sources16
Helixi310 – 318Combined sources9
Beta strandi326 – 335Combined sources10
Beta strandi338 – 345Combined sources8
Helixi350 – 364Combined sources15
Beta strandi369 – 373Combined sources5
Helixi378 – 383Combined sources6
Helixi385 – 392Combined sources8
Beta strandi395 – 401Combined sources7
Helixi416 – 426Combined sources11
Beta strandi432 – 435Combined sources4
Helixi437 – 439Combined sources3
Helixi440 – 447Combined sources8
Beta strandi453 – 457Combined sources5
Helixi462 – 472Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GQQX-ray3.10A/B1-475[»]
1GQYX-ray1.80A/B1-475[»]
1P31X-ray1.85A/B1-475[»]
1P3DX-ray1.70A/B1-475[»]
ProteinModelPortaliP45066.
SMRiP45066.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP45066.

Family & Domainsi

Sequence similaritiesi

Belongs to the MurCDEF family.Curated

Phylogenomic databases

eggNOGiENOG4105DFU. Bacteria.
COG0773. LUCA.
KOiK01924.
OMAiFHFIGIG.
PhylomeDBiP45066.

Family and domain databases

Gene3Di3.40.1190.10. 1 hit.
3.40.50.720. 1 hit.
3.90.190.20. 1 hit.
HAMAPiMF_00046. MurC. 1 hit.
InterProiIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR016040. NAD(P)-bd_dom.
IPR005758. UDP-N-AcMur_Ala_ligase_murC.
[Graphical view]
PfamiPF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMiSSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
TIGRFAMsiTIGR01082. murC. 1 hit.

Sequencei

Sequence statusi: Complete.

P45066-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKHSHEEIRK IIPEMRRVQQ IHFIGIGGAG MSGIAEILLN EGYQISGSDI
60 70 80 90 100
ADGVVTQRLA QAGAKIYIGH AEEHIEGASV VVVSSAIKDD NPELVTSKQK
110 120 130 140 150
RIPVIQRAQM LAEIMRFRHG IAVAGTHGKT TTTAMISMIY TQAKLDPTFV
160 170 180 190 200
NGGLVKSAGK NAHLGASRYL IAEADESDAS FLHLQPMVSV VTNMEPDHMD
210 220 230 240 250
TYEGDFEKMK ATYVKFLHNL PFYGLAVMCA DDPVLMELVP KVGRQVITYG
260 270 280 290 300
FSEQADYRIE DYEQTGFQGH YTVICPNNER INVLLNVPGK HNALNATAAL
310 320 330 340 350
AVAKEEGIAN EAILEALADF QGAGRRFDQL GEFIRPNGKV RLVDDYGHHP
360 370 380 390 400
TEVGVTIKAA REGWGDKRIV MIFQPHRYSR TRDLFDDFVQ VLSQVDALIM
410 420 430 440 450
LDVYAAGEAP IVGADSKSLC RSIRNLGKVD PILVSDTSQL GDVLDQIIQD
460 470
GDLILAQGAG SVSKISRGLA ESWKN
Length:475
Mass (Da):51,994
Last modified:November 1, 1995 - v1
Checksum:i5748EDD753D6F8D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22794.1.
PIRiE64185.
RefSeqiNP_439297.1. NC_000907.1.
WP_005693453.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22794; AAC22794; HI_1139.
GeneIDi949618.
KEGGihin:HI1139.
PATRICi20190953. VBIHaeInf48452_1189.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22794.1.
PIRiE64185.
RefSeqiNP_439297.1. NC_000907.1.
WP_005693453.1. NC_000907.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GQQX-ray3.10A/B1-475[»]
1GQYX-ray1.80A/B1-475[»]
1P31X-ray1.85A/B1-475[»]
1P3DX-ray1.70A/B1-475[»]
ProteinModelPortaliP45066.
SMRiP45066.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI1139.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC22794; AAC22794; HI_1139.
GeneIDi949618.
KEGGihin:HI1139.
PATRICi20190953. VBIHaeInf48452_1189.

Phylogenomic databases

eggNOGiENOG4105DFU. Bacteria.
COG0773. LUCA.
KOiK01924.
OMAiFHFIGIG.
PhylomeDBiP45066.

Enzyme and pathway databases

UniPathwayiUPA00219.
BRENDAi6.3.2.8. 2529.

Miscellaneous databases

EvolutionaryTraceiP45066.

Family and domain databases

Gene3Di3.40.1190.10. 1 hit.
3.40.50.720. 1 hit.
3.90.190.20. 1 hit.
HAMAPiMF_00046. MurC. 1 hit.
InterProiIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR016040. NAD(P)-bd_dom.
IPR005758. UDP-N-AcMur_Ala_ligase_murC.
[Graphical view]
PfamiPF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMiSSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
TIGRFAMsiTIGR01082. murC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMURC_HAEIN
AccessioniPrimary (citable) accession number: P45066
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.