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Protein

UDP-N-acetylmuramate--L-alanine ligase

Gene

murC

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cell wall formation.

Catalytic activityi

ATP + UDP-N-acetyl-alpha-D-muramate + L-alanine = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine.

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi125 – 1317ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi6.3.2.8. 2529.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylmuramate--L-alanine ligase (EC:6.3.2.8)
Alternative name(s):
UDP-N-acetylmuramoyl-L-alanine synthetase
Gene namesi
Name:murC
Ordered Locus Names:HI_1139
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 475475UDP-N-acetylmuramate--L-alanine ligasePRO_0000182100Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI1139.

Structurei

Secondary structure

1
475
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 97Combined sources
Beta strandi20 – 256Combined sources
Helixi31 – 4111Combined sources
Beta strandi44 – 507Combined sources
Helixi54 – 618Combined sources
Beta strandi65 – 695Combined sources
Helixi72 – 754Combined sources
Beta strandi79 – 835Combined sources
Beta strandi85 – 873Combined sources
Helixi92 – 998Combined sources
Beta strandi104 – 1063Combined sources
Helixi107 – 11610Combined sources
Beta strandi118 – 12710Combined sources
Helixi129 – 14214Combined sources
Beta strandi148 – 1503Combined sources
Turni156 – 1583Combined sources
Beta strandi159 – 1635Combined sources
Beta strandi166 – 1738Combined sources
Helixi180 – 1834Combined sources
Beta strandi187 – 1915Combined sources
Helixi199 – 2024Combined sources
Helixi206 – 21712Combined sources
Beta strandi225 – 2295Combined sources
Helixi233 – 24210Combined sources
Beta strandi244 – 2529Combined sources
Beta strandi256 – 26510Combined sources
Beta strandi268 – 2747Combined sources
Beta strandi280 – 2878Combined sources
Helixi290 – 30516Combined sources
Helixi310 – 3189Combined sources
Beta strandi326 – 33510Combined sources
Beta strandi338 – 3458Combined sources
Helixi350 – 36415Combined sources
Beta strandi369 – 3735Combined sources
Helixi378 – 3836Combined sources
Helixi385 – 3928Combined sources
Beta strandi395 – 4017Combined sources
Helixi416 – 42611Combined sources
Beta strandi432 – 4354Combined sources
Helixi437 – 4393Combined sources
Helixi440 – 4478Combined sources
Beta strandi453 – 4575Combined sources
Helixi462 – 47211Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1GQQX-ray3.10A/B1-475[»]
1GQYX-ray1.80A/B1-475[»]
1P31X-ray1.85A/B1-475[»]
1P3DX-ray1.70A/B1-475[»]
ProteinModelPortaliP45066.
SMRiP45066. Positions 6-474.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP45066.

Family & Domainsi

Sequence similaritiesi

Belongs to the MurCDEF family.Curated

Phylogenomic databases

eggNOGiENOG4105DFU. Bacteria.
COG0773. LUCA.
KOiK01924.
OMAiFHFIGIG.
PhylomeDBiP45066.

Family and domain databases

Gene3Di3.40.1190.10. 1 hit.
3.40.50.720. 1 hit.
3.90.190.20. 1 hit.
HAMAPiMF_00046. MurC. 1 hit.
InterProiIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR016040. NAD(P)-bd_dom.
IPR005758. UDP-N-AcMur_Ala_ligase_murC.
[Graphical view]
PfamiPF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMiSSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
TIGRFAMsiTIGR01082. murC. 1 hit.

Sequencei

Sequence statusi: Complete.

P45066-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKHSHEEIRK IIPEMRRVQQ IHFIGIGGAG MSGIAEILLN EGYQISGSDI
60 70 80 90 100
ADGVVTQRLA QAGAKIYIGH AEEHIEGASV VVVSSAIKDD NPELVTSKQK
110 120 130 140 150
RIPVIQRAQM LAEIMRFRHG IAVAGTHGKT TTTAMISMIY TQAKLDPTFV
160 170 180 190 200
NGGLVKSAGK NAHLGASRYL IAEADESDAS FLHLQPMVSV VTNMEPDHMD
210 220 230 240 250
TYEGDFEKMK ATYVKFLHNL PFYGLAVMCA DDPVLMELVP KVGRQVITYG
260 270 280 290 300
FSEQADYRIE DYEQTGFQGH YTVICPNNER INVLLNVPGK HNALNATAAL
310 320 330 340 350
AVAKEEGIAN EAILEALADF QGAGRRFDQL GEFIRPNGKV RLVDDYGHHP
360 370 380 390 400
TEVGVTIKAA REGWGDKRIV MIFQPHRYSR TRDLFDDFVQ VLSQVDALIM
410 420 430 440 450
LDVYAAGEAP IVGADSKSLC RSIRNLGKVD PILVSDTSQL GDVLDQIIQD
460 470
GDLILAQGAG SVSKISRGLA ESWKN
Length:475
Mass (Da):51,994
Last modified:November 1, 1995 - v1
Checksum:i5748EDD753D6F8D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22794.1.
PIRiE64185.
RefSeqiNP_439297.1. NC_000907.1.
WP_005693453.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22794; AAC22794; HI_1139.
GeneIDi949618.
KEGGihin:HI1139.
PATRICi20190953. VBIHaeInf48452_1189.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22794.1.
PIRiE64185.
RefSeqiNP_439297.1. NC_000907.1.
WP_005693453.1. NC_000907.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1GQQX-ray3.10A/B1-475[»]
1GQYX-ray1.80A/B1-475[»]
1P31X-ray1.85A/B1-475[»]
1P3DX-ray1.70A/B1-475[»]
ProteinModelPortaliP45066.
SMRiP45066. Positions 6-474.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI1139.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC22794; AAC22794; HI_1139.
GeneIDi949618.
KEGGihin:HI1139.
PATRICi20190953. VBIHaeInf48452_1189.

Phylogenomic databases

eggNOGiENOG4105DFU. Bacteria.
COG0773. LUCA.
KOiK01924.
OMAiFHFIGIG.
PhylomeDBiP45066.

Enzyme and pathway databases

UniPathwayiUPA00219.
BRENDAi6.3.2.8. 2529.

Miscellaneous databases

EvolutionaryTraceiP45066.

Family and domain databases

Gene3Di3.40.1190.10. 1 hit.
3.40.50.720. 1 hit.
3.90.190.20. 1 hit.
HAMAPiMF_00046. MurC. 1 hit.
InterProiIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR016040. NAD(P)-bd_dom.
IPR005758. UDP-N-AcMur_Ala_ligase_murC.
[Graphical view]
PfamiPF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMiSSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
TIGRFAMsiTIGR01082. murC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMURC_HAEIN
AccessioniPrimary (citable) accession number: P45066
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 7, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.