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P45061 (MURF_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase

EC=6.3.2.10
Alternative name(s):
D-alanyl-D-alanine-adding enzyme
UDP-MurNAc-pentapeptide synthetase
Gene names
Name:murF
Ordered Locus Names:HI_1134
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length457 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein By similarity.

Catalytic activity

ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis.

Subunit structure

Monomer By similarity.

Subcellular location

Cytoplasm Probable.

Sequence similarities

Belongs to the MurCDEF family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 457457UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
PRO_0000101699

Regions

Nucleotide binding109 – 1157ATP Potential

Sequences

Sequence LengthMass (Da)Tools
P45061 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 095EFE74F27CD28B

FASTA45750,073
        10         20         30         40         50         60 
MIKLSTVQLA QILQAKLIGD ENVQVEKINT DTRKSVSNSL FFALKGEKFD AHQYLDQAVS 

        70         80         90        100        110        120 
QGALALVVQQ ENSSISVPQL VVKDTRIALG ELAKWLREKI NPRTVAMTGS SGKTTVKEMT 

       130        140        150        160        170        180 
ASILQHTAAD SEAVLFTNGN FNNDIGVPLT LLRLTEKHRF AVIELGANHQ NEINYTTKLV 

       190        200        210        220        230        240 
QPNAALINNI APAHLEGFGS LAGVVQAKGE IYRGLTKNGV AIINAEHNHL DIWQKEISNH 

       250        260        270        280        290        300 
AIQYFNGKDY SAKNIHHTSQ GSTFTLISPQ GEIEITLPYL GEHNVKNALA ATALAMNVGA 

       310        320        330        340        350        360 
TLTDVKAGLE QRSQVKGRLF PIQVTPNLLL LDDTYNANKD SLCAAIDVLK GYDAFRILCV 

       370        380        390        400        410        420 
GDMKELGENS LAIHREVGQY INLVNLDLVC SYGNESAVIS EAVSGKHFTD KTEMVDFLVP 

       430        440        450 
LIENQLQQNK KVVVLGKGSR SMKMEDVIYS LKDKIKC 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC22789.1.
PIRI64184.
RefSeqNP_439292.1. NC_000907.1.

3D structure databases

ProteinModelPortalP45061.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI1134.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC22789; AAC22789; HI_1134.
GeneID950620.
KEGGhin:HI1134.
PATRIC20190943. VBIHaeInf48452_1184.

Phylogenomic databases

eggNOGCOG0770.
KOK01929.
OMAANHLGEI.
OrthoDBEOG6PKFCR.
ProtClustDBCLSK869981.

Enzyme and pathway databases

UniPathwayUPA00219.

Family and domain databases

Gene3D3.40.1190.10. 1 hit.
3.40.1390.10. 1 hit.
3.90.190.20. 1 hit.
InterProIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR005863. UDP-N-AcMur-pentapeptide_synth.
[Graphical view]
PANTHERPTHR23135:SF3. PTHR23135:SF3. 1 hit.
PfamPF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMSSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
SSF63418. SSF63418. 1 hit.
TIGRFAMsTIGR01143. murF. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURF_HAEIN
AccessionPrimary (citable) accession number: P45061
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 19, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names