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P45059

- FTSI_HAEIN

UniProt

P45059 - FTSI_HAEIN

Protein

Peptidoglycan synthase FtsI

Gene

ftsI

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Cell wall formation. Essential for the formation of a septum of the murein sacculus. Synthesis of cross-linked peptidoglycan from the lipid intermediates By similarity.By similarity

    Catalytic activityi

    (GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala))(n)-diphosphoundecaprenol + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = (GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala))(n+1)-diphosphoundecaprenol + undecaprenyl diphosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei327 – 3271Acyl-ester intermediateBy similarity

    GO - Molecular functioni

    1. penicillin binding Source: InterPro
    2. peptidoglycan glycosyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
    4. regulation of cell shape Source: UniProtKB-KW
    5. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Antibiotic resistance, Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    UniPathwayiUPA00219.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptidoglycan synthase FtsI (EC:2.4.1.129)
    Alternative name(s):
    Penicillin-binding protein 3
    Short name:
    PBP-3
    Peptidoglycan glycosyltransferase 3
    Gene namesi
    Name:ftsI
    Ordered Locus Names:HI_1132
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    Pathology & Biotechi

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 610610Peptidoglycan synthase FtsIPRO_0000195457Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi71421.HI1132.

    Structurei

    3D structure databases

    ProteinModelPortaliP45059.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    Has an N-terminal penicillin insensitive transglycosylase domain (formation of linear glycan strands) and a C-terminal penicillin-sensitive transpeptidase domain (cross-linking of the peptide subunits).

    Sequence similaritiesi

    Belongs to the transpeptidase family.Curated

    Phylogenomic databases

    eggNOGiCOG0768.
    KOiK03587.
    OMAiFILDGHR.
    OrthoDBiEOG6N0HHV.
    PhylomeDBiP45059.

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    InterProiIPR012338. Beta-lactam/transpept-like.
    IPR005311. PBP_dimer.
    IPR001460. PCN-bd_Tpept.
    [Graphical view]
    PfamiPF03717. PBP_dimer. 1 hit.
    PF00905. Transpeptidase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56519. SSF56519. 1 hit.
    SSF56601. SSF56601. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P45059-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVKFNSSRKS GKSKKTIRKL TAPETVKQNK PQKVFEKCFM RGRYMLSTVL    50
    ILLGLCALVA RAAYVQSINA DTLSNEADKR SLRKDEVLSV RGSILDRNGQ 100
    LLSVSVPMSA IVADPKTMLK ENSLADKERI AALAEELGMT ENDLVKKIEK 150
    NSKSGYLYLA RQVELSKANY IRRLKIKGII LETEHRRFYP RVEEAAHVVG 200
    YTDIDGNGIE GIEKSFNSLL VGKDGSRTVR KDKRGNIVAH ISDEKKYDAQ 250
    DVTLSIDEKL QSMVYREIKK AVSENNAESG TAVLVDVRTG EVLAMATAPS 300
    YNPNNRVGVK SELMRNRAIT DTFEPGSTVK PFVVLTALQR GVVKRDEIID 350
    TTSFKLSGKE IVDVAPRAQQ TLDEILMNSS NRGVSRLALR MPPSALMETY 400
    QNAGLSKPTD LGLIGEQVGI LNANRKRWAD IERATVAYGY GITATPLQIA 450
    RAYATLGSFG VYRPLSITKV DPPVIGKRVF SEKITKDIVG ILEKVAIKNK 500
    RAMVEGYRVG VKTGTARKIE NGHYVNKYVA FTAGIAPISD PRYALVVLIN 550
    DPKAGEYYGG AVSAPVFSNI MGYALRANAI PQDAEAAENT TTKSAKRIVY 600
    IGEHKNQKVN 610
    Length:610
    Mass (Da):67,166
    Last modified:November 1, 1995 - v1
    Checksum:i8A1DA5538235C0A3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22787.1.
    PIRiG64184.
    RefSeqiNP_439290.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC22787; AAC22787; HI_1132.
    GeneIDi950626.
    KEGGihin:HI1132.
    PATRICi20190939. VBIHaeInf48452_1182.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22787.1 .
    PIRi G64184.
    RefSeqi NP_439290.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P45059.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI1132.

    Chemistry

    DrugBanki DB00303. Ertapenem.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC22787 ; AAC22787 ; HI_1132 .
    GeneIDi 950626.
    KEGGi hin:HI1132.
    PATRICi 20190939. VBIHaeInf48452_1182.

    Phylogenomic databases

    eggNOGi COG0768.
    KOi K03587.
    OMAi FILDGHR.
    OrthoDBi EOG6N0HHV.
    PhylomeDBi P45059.

    Enzyme and pathway databases

    UniPathwayi UPA00219 .

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    InterProi IPR012338. Beta-lactam/transpept-like.
    IPR005311. PBP_dimer.
    IPR001460. PCN-bd_Tpept.
    [Graphical view ]
    Pfami PF03717. PBP_dimer. 1 hit.
    PF00905. Transpeptidase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56519. SSF56519. 1 hit.
    SSF56601. SSF56601. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiFTSI_HAEIN
    AccessioniPrimary (citable) accession number: P45059
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3