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Protein

Peptidoglycan D,D-transpeptidase FtsI

Gene

ftsI

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes cross-linking of the peptidoglycan cell wall at the division septum.UniRule annotation

Catalytic activityi

Preferential cleavage: (Ac)2-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei327Acyl-ester intermediateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Protease
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis, Septation

Enzyme and pathway databases

BioCyciHINF71421:G1GJ1-1165-MONOMER
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidoglycan D,D-transpeptidase FtsIUniRule annotation (EC:3.4.16.4UniRule annotation)
Alternative name(s):
Penicillin-binding protein 3UniRule annotation
Short name:
PBP-3UniRule annotation
Gene namesi
Name:ftsIUniRule annotation
Ordered Locus Names:HI_1132
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Single-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei43 – 65HelicalUniRule annotationAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

DrugBankiDB00303 Ertapenem

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001954571 – 610Peptidoglycan D,D-transpeptidase FtsIAdd BLAST610

Proteomic databases

PRIDEiP45059

Interactioni

Protein-protein interaction databases

STRINGi71421.HI1132

Structurei

3D structure databases

ProteinModelPortaliP45059
SMRiP45059
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the transpeptidase family. FtsI subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CJN Bacteria
COG0768 LUCA
KOiK03587
OMAiNVGMIKI
PhylomeDBiP45059

Family and domain databases

HAMAPiMF_02080 FtsI_transpept, 1 hit
InterProiView protein in InterPro
IPR012338 Beta-lactam/transpept-like
IPR037532 FtsI_transpept
IPR005311 PBP_dimer
IPR036138 PBP_dimer_sf
IPR001460 PCN-bd_Tpept
PfamiView protein in Pfam
PF03717 PBP_dimer, 1 hit
PF00905 Transpeptidase, 1 hit
SUPFAMiSSF56519 SSF56519, 1 hit
SSF56601 SSF56601, 1 hit

Sequencei

Sequence statusi: Complete.

P45059-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKFNSSRKS GKSKKTIRKL TAPETVKQNK PQKVFEKCFM RGRYMLSTVL
60 70 80 90 100
ILLGLCALVA RAAYVQSINA DTLSNEADKR SLRKDEVLSV RGSILDRNGQ
110 120 130 140 150
LLSVSVPMSA IVADPKTMLK ENSLADKERI AALAEELGMT ENDLVKKIEK
160 170 180 190 200
NSKSGYLYLA RQVELSKANY IRRLKIKGII LETEHRRFYP RVEEAAHVVG
210 220 230 240 250
YTDIDGNGIE GIEKSFNSLL VGKDGSRTVR KDKRGNIVAH ISDEKKYDAQ
260 270 280 290 300
DVTLSIDEKL QSMVYREIKK AVSENNAESG TAVLVDVRTG EVLAMATAPS
310 320 330 340 350
YNPNNRVGVK SELMRNRAIT DTFEPGSTVK PFVVLTALQR GVVKRDEIID
360 370 380 390 400
TTSFKLSGKE IVDVAPRAQQ TLDEILMNSS NRGVSRLALR MPPSALMETY
410 420 430 440 450
QNAGLSKPTD LGLIGEQVGI LNANRKRWAD IERATVAYGY GITATPLQIA
460 470 480 490 500
RAYATLGSFG VYRPLSITKV DPPVIGKRVF SEKITKDIVG ILEKVAIKNK
510 520 530 540 550
RAMVEGYRVG VKTGTARKIE NGHYVNKYVA FTAGIAPISD PRYALVVLIN
560 570 580 590 600
DPKAGEYYGG AVSAPVFSNI MGYALRANAI PQDAEAAENT TTKSAKRIVY
610
IGEHKNQKVN
Length:610
Mass (Da):67,166
Last modified:November 1, 1995 - v1
Checksum:i8A1DA5538235C0A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA Translation: AAC22787.1
PIRiG64184
RefSeqiNP_439290.1, NC_000907.1
WP_005693446.1, NC_000907.1

Genome annotation databases

EnsemblBacteriaiAAC22787; AAC22787; HI_1132
GeneIDi950626
KEGGihin:HI1132
PATRICifig|71421.8.peg.1182

Similar proteinsi

Entry informationi

Entry nameiFTSI_HAEIN
AccessioniPrimary (citable) accession number: P45059
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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