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P45059 (FTSI_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Peptidoglycan synthase FtsI

EC=2.4.1.129
Alternative name(s):
Penicillin-binding protein 3
Short name=PBP-3
Peptidoglycan glycosyltransferase 3
Gene names
Name:ftsI
Ordered Locus Names:HI_1132
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length610 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Essential for the formation of a septum of the murein sacculus. Synthesis of cross-linked peptidoglycan from the lipid intermediates By similarity.

Catalytic activity

(GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala))(n)-diphosphoundecaprenol + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = (GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala))(n+1)-diphosphoundecaprenol + undecaprenyl diphosphate.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis.

Subcellular location

Cell inner membrane Potential.

Domain

Has an N-terminal penicillin insensitive transglycosylase domain (formation of linear glycan strands) and a C-terminal penicillin-sensitive transpeptidase domain (cross-linking of the peptide subunits).

Sequence similarities

Belongs to the transpeptidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 610610Peptidoglycan synthase FtsI
PRO_0000195457

Sites

Active site3271Acyl-ester intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
P45059 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 8A1DA5538235C0A3

FASTA61067,166
        10         20         30         40         50         60 
MVKFNSSRKS GKSKKTIRKL TAPETVKQNK PQKVFEKCFM RGRYMLSTVL ILLGLCALVA 

        70         80         90        100        110        120 
RAAYVQSINA DTLSNEADKR SLRKDEVLSV RGSILDRNGQ LLSVSVPMSA IVADPKTMLK 

       130        140        150        160        170        180 
ENSLADKERI AALAEELGMT ENDLVKKIEK NSKSGYLYLA RQVELSKANY IRRLKIKGII 

       190        200        210        220        230        240 
LETEHRRFYP RVEEAAHVVG YTDIDGNGIE GIEKSFNSLL VGKDGSRTVR KDKRGNIVAH 

       250        260        270        280        290        300 
ISDEKKYDAQ DVTLSIDEKL QSMVYREIKK AVSENNAESG TAVLVDVRTG EVLAMATAPS 

       310        320        330        340        350        360 
YNPNNRVGVK SELMRNRAIT DTFEPGSTVK PFVVLTALQR GVVKRDEIID TTSFKLSGKE 

       370        380        390        400        410        420 
IVDVAPRAQQ TLDEILMNSS NRGVSRLALR MPPSALMETY QNAGLSKPTD LGLIGEQVGI 

       430        440        450        460        470        480 
LNANRKRWAD IERATVAYGY GITATPLQIA RAYATLGSFG VYRPLSITKV DPPVIGKRVF 

       490        500        510        520        530        540 
SEKITKDIVG ILEKVAIKNK RAMVEGYRVG VKTGTARKIE NGHYVNKYVA FTAGIAPISD 

       550        560        570        580        590        600 
PRYALVVLIN DPKAGEYYGG AVSAPVFSNI MGYALRANAI PQDAEAAENT TTKSAKRIVY 

       610 
IGEHKNQKVN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC22787.1.
PIRG64184.
RefSeqNP_439290.1. NC_000907.1.

3D structure databases

ProteinModelPortalP45059.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI1132.

Chemistry

DrugBankDB00303. Ertapenem.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC22787; AAC22787; HI_1132.
GeneID950626.
KEGGhin:HI1132.
PATRIC20190939. VBIHaeInf48452_1182.

Phylogenomic databases

eggNOGCOG0768.
KOK03587.
OMAMTSDQPL.
OrthoDBEOG6N0HHV.
ProtClustDBCLSK869980.

Enzyme and pathway databases

UniPathwayUPA00219.

Family and domain databases

Gene3D3.40.710.10. 1 hit.
InterProIPR012338. Beta-lactam/transpept-like.
IPR005311. PBP_dimer.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamPF03717. PBP_dimer. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMSSF56519. SSF56519. 1 hit.
SSF56601. SSF56601. 1 hit.
ProtoNetSearch...

Entry information

Entry nameFTSI_HAEIN
AccessionPrimary (citable) accession number: P45059
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: December 11, 2013
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names