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P45059

- FTSI_HAEIN

UniProt

P45059 - FTSI_HAEIN

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Protein
Peptidoglycan synthase FtsI
Gene
ftsI, HI_1132
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cell wall formation. Essential for the formation of a septum of the murein sacculus. Synthesis of cross-linked peptidoglycan from the lipid intermediates By similarity.

Catalytic activityi

(GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala))(n)-diphosphoundecaprenol + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = (GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala))(n+1)-diphosphoundecaprenol + undecaprenyl diphosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei327 – 3271Acyl-ester intermediate By similarity

GO - Molecular functioni

  1. penicillin binding Source: InterPro
  2. peptidoglycan glycosyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
  4. regulation of cell shape Source: UniProtKB-KW
  5. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Antibiotic resistance, Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidoglycan synthase FtsI (EC:2.4.1.129)
Alternative name(s):
Penicillin-binding protein 3
Short name:
PBP-3
Peptidoglycan glycosyltransferase 3
Gene namesi
Name:ftsI
Ordered Locus Names:HI_1132
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

Subcellular locationi

Cell inner membrane Reviewed prediction

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 610610Peptidoglycan synthase FtsI
PRO_0000195457Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI1132.

Structurei

3D structure databases

ProteinModelPortaliP45059.

Family & Domainsi

Domaini

Has an N-terminal penicillin insensitive transglycosylase domain (formation of linear glycan strands) and a C-terminal penicillin-sensitive transpeptidase domain (cross-linking of the peptide subunits).

Sequence similaritiesi

Belongs to the transpeptidase family.

Phylogenomic databases

eggNOGiCOG0768.
KOiK03587.
OMAiFILDGHR.
OrthoDBiEOG6N0HHV.
PhylomeDBiP45059.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR005311. PBP_dimer.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamiPF03717. PBP_dimer. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMiSSF56519. SSF56519. 1 hit.
SSF56601. SSF56601. 1 hit.

Sequencei

Sequence statusi: Complete.

P45059-1 [UniParc]FASTAAdd to Basket

« Hide

MVKFNSSRKS GKSKKTIRKL TAPETVKQNK PQKVFEKCFM RGRYMLSTVL    50
ILLGLCALVA RAAYVQSINA DTLSNEADKR SLRKDEVLSV RGSILDRNGQ 100
LLSVSVPMSA IVADPKTMLK ENSLADKERI AALAEELGMT ENDLVKKIEK 150
NSKSGYLYLA RQVELSKANY IRRLKIKGII LETEHRRFYP RVEEAAHVVG 200
YTDIDGNGIE GIEKSFNSLL VGKDGSRTVR KDKRGNIVAH ISDEKKYDAQ 250
DVTLSIDEKL QSMVYREIKK AVSENNAESG TAVLVDVRTG EVLAMATAPS 300
YNPNNRVGVK SELMRNRAIT DTFEPGSTVK PFVVLTALQR GVVKRDEIID 350
TTSFKLSGKE IVDVAPRAQQ TLDEILMNSS NRGVSRLALR MPPSALMETY 400
QNAGLSKPTD LGLIGEQVGI LNANRKRWAD IERATVAYGY GITATPLQIA 450
RAYATLGSFG VYRPLSITKV DPPVIGKRVF SEKITKDIVG ILEKVAIKNK 500
RAMVEGYRVG VKTGTARKIE NGHYVNKYVA FTAGIAPISD PRYALVVLIN 550
DPKAGEYYGG AVSAPVFSNI MGYALRANAI PQDAEAAENT TTKSAKRIVY 600
IGEHKNQKVN 610
Length:610
Mass (Da):67,166
Last modified:November 1, 1995 - v1
Checksum:i8A1DA5538235C0A3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22787.1.
PIRiG64184.
RefSeqiNP_439290.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22787; AAC22787; HI_1132.
GeneIDi950626.
KEGGihin:HI1132.
PATRICi20190939. VBIHaeInf48452_1182.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22787.1 .
PIRi G64184.
RefSeqi NP_439290.1. NC_000907.1.

3D structure databases

ProteinModelPortali P45059.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI1132.

Chemistry

DrugBanki DB00303. Ertapenem.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC22787 ; AAC22787 ; HI_1132 .
GeneIDi 950626.
KEGGi hin:HI1132.
PATRICi 20190939. VBIHaeInf48452_1182.

Phylogenomic databases

eggNOGi COG0768.
KOi K03587.
OMAi FILDGHR.
OrthoDBi EOG6N0HHV.
PhylomeDBi P45059.

Enzyme and pathway databases

UniPathwayi UPA00219 .

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR005311. PBP_dimer.
IPR001460. PCN-bd_Tpept.
[Graphical view ]
Pfami PF03717. PBP_dimer. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view ]
SUPFAMi SSF56519. SSF56519. 1 hit.
SSF56601. SSF56601. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiFTSI_HAEIN
AccessioniPrimary (citable) accession number: P45059
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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