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Protein

Peptidoglycan synthase FtsI

Gene

ftsI

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cell wall formation. Essential for the formation of a septum of the murein sacculus. Synthesis of cross-linked peptidoglycan from the lipid intermediates (By similarity).By similarity

Catalytic activityi

(GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala))(n)-diphosphoundecaprenol + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = (GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala))(n+1)-diphosphoundecaprenol + undecaprenyl diphosphate.

Pathway:ipeptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei327 – 3271Acyl-ester intermediateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Antibiotic resistance, Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidoglycan synthase FtsI (EC:2.4.1.129)
Alternative name(s):
Penicillin-binding protein 3
Short name:
PBP-3
Peptidoglycan glycosyltransferase 3
Gene namesi
Name:ftsI
Ordered Locus Names:HI_1132
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Chemistry

DrugBankiDB00303. Ertapenem.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 610610Peptidoglycan synthase FtsIPRO_0000195457Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI1132.

Structurei

3D structure databases

ProteinModelPortaliP45059.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Has an N-terminal penicillin insensitive transglycosylase domain (formation of linear glycan strands) and a C-terminal penicillin-sensitive transpeptidase domain (cross-linking of the peptide subunits).

Sequence similaritiesi

Belongs to the transpeptidase family.Curated

Phylogenomic databases

eggNOGiCOG0768.
KOiK03587.
OMAiYNPNNRV.
OrthoDBiEOG6N0HHV.
PhylomeDBiP45059.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR005311. PBP_dimer.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamiPF03717. PBP_dimer. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMiSSF56519. SSF56519. 1 hit.
SSF56601. SSF56601. 1 hit.

Sequencei

Sequence statusi: Complete.

P45059-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKFNSSRKS GKSKKTIRKL TAPETVKQNK PQKVFEKCFM RGRYMLSTVL
60 70 80 90 100
ILLGLCALVA RAAYVQSINA DTLSNEADKR SLRKDEVLSV RGSILDRNGQ
110 120 130 140 150
LLSVSVPMSA IVADPKTMLK ENSLADKERI AALAEELGMT ENDLVKKIEK
160 170 180 190 200
NSKSGYLYLA RQVELSKANY IRRLKIKGII LETEHRRFYP RVEEAAHVVG
210 220 230 240 250
YTDIDGNGIE GIEKSFNSLL VGKDGSRTVR KDKRGNIVAH ISDEKKYDAQ
260 270 280 290 300
DVTLSIDEKL QSMVYREIKK AVSENNAESG TAVLVDVRTG EVLAMATAPS
310 320 330 340 350
YNPNNRVGVK SELMRNRAIT DTFEPGSTVK PFVVLTALQR GVVKRDEIID
360 370 380 390 400
TTSFKLSGKE IVDVAPRAQQ TLDEILMNSS NRGVSRLALR MPPSALMETY
410 420 430 440 450
QNAGLSKPTD LGLIGEQVGI LNANRKRWAD IERATVAYGY GITATPLQIA
460 470 480 490 500
RAYATLGSFG VYRPLSITKV DPPVIGKRVF SEKITKDIVG ILEKVAIKNK
510 520 530 540 550
RAMVEGYRVG VKTGTARKIE NGHYVNKYVA FTAGIAPISD PRYALVVLIN
560 570 580 590 600
DPKAGEYYGG AVSAPVFSNI MGYALRANAI PQDAEAAENT TTKSAKRIVY
610
IGEHKNQKVN
Length:610
Mass (Da):67,166
Last modified:November 1, 1995 - v1
Checksum:i8A1DA5538235C0A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22787.1.
PIRiG64184.
RefSeqiNP_439290.1. NC_000907.1.
WP_005693446.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22787; AAC22787; HI_1132.
GeneIDi950626.
KEGGihin:HI1132.
PATRICi20190939. VBIHaeInf48452_1182.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22787.1.
PIRiG64184.
RefSeqiNP_439290.1. NC_000907.1.
WP_005693446.1. NC_000907.1.

3D structure databases

ProteinModelPortaliP45059.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI1132.

Chemistry

DrugBankiDB00303. Ertapenem.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC22787; AAC22787; HI_1132.
GeneIDi950626.
KEGGihin:HI1132.
PATRICi20190939. VBIHaeInf48452_1182.

Phylogenomic databases

eggNOGiCOG0768.
KOiK03587.
OMAiYNPNNRV.
OrthoDBiEOG6N0HHV.
PhylomeDBiP45059.

Enzyme and pathway databases

UniPathwayiUPA00219.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR005311. PBP_dimer.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamiPF03717. PBP_dimer. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMiSSF56519. SSF56519. 1 hit.
SSF56601. SSF56601. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiFTSI_HAEIN
AccessioniPrimary (citable) accession number: P45059
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 22, 2015
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.