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Protein

Transaldolase

Gene

tal

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.By similarity

Catalytic activityi

Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate.

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Transaldolase (tal)
  3. no protein annotated in this organism
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei132Schiff-base intermediate with substrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processPentose shunt
LigandSchiff base

Enzyme and pathway databases

UniPathwayiUPA00115; UER00414.

Names & Taxonomyi

Protein namesi
Recommended name:
Transaldolase (EC:2.2.1.2)
Gene namesi
Name:tal
Synonyms:talB
Ordered Locus Names:HI_1125
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001735992 – 317TransaldolaseAdd BLAST316

Proteomic databases

PRIDEiP45055.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi71421.HI1125.

Structurei

3D structure databases

ProteinModelPortaliP45055.
SMRiP45055.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the transaldolase family. Type 1 subfamily.Curated

Phylogenomic databases

eggNOGiENOG4105CW3. Bacteria.
COG0176. LUCA.
KOiK00616.
OMAiMAFDKLH.
PhylomeDBiP45055.

Family and domain databases

CDDicd00957. Transaldolase_TalAB. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00492. Transaldolase_1. 1 hit.
InterProiView protein in InterPro
IPR013785. Aldolase_TIM.
IPR001585. TAL/FSA.
IPR004730. Transaldolase_1.
IPR018225. Transaldolase_AS.
PANTHERiPTHR10683. PTHR10683. 1 hit.
PTHR10683:SF20. PTHR10683:SF20. 1 hit.
PfamiView protein in Pfam
PF00923. TAL_FSA. 1 hit.
TIGRFAMsiTIGR00874. talAB. 1 hit.
PROSITEiView protein in PROSITE
PS01054. TRANSALDOLASE_1. 1 hit.
PS00958. TRANSALDOLASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P45055-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTQLDSLRN MTVVVADTGD IDAIKKYQPQ DATTNPSLIL SASALPQYAP
60 70 80 90 100
LIDEAVAYAK AQSADKAQQL IDAEDKLAVN IGLEILKIVP GRISTEVDAR
110 120 130 140 150
LSYDTQATVE KARKLIALYN AAGISNDRIL IKIASTWQGI RAAEILEKEG
160 170 180 190 200
INCNLTLLFS EAQARACAEA GVYLISPFVG RILDWYKANS DKKEYAPAED
210 220 230 240 250
PGVISVTKIY NYYKEYGYNT VVMGASFRNV GEITELAGCD RLTIAPALLK
260 270 280 290 300
ELQENSTALV RKLEYKGEVK AKPQPLTEAE FYWQHNSDAM AVEKLAEGIR
310
KFAIDQEKLE TMLSAKL
Length:317
Mass (Da):34,905
Last modified:January 23, 2007 - v2
Checksum:iE48A7E6DCABECF5A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22779.1.
PIRiD64167.
RefSeqiNP_439282.1. NC_000907.1.
WP_005693444.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22779; AAC22779; HI_1125.
GeneIDi950099.
KEGGihin:HI1125.
PATRICifig|71421.8.peg.1174.

Similar proteinsi

Entry informationi

Entry nameiTAL_HAEIN
AccessioniPrimary (citable) accession number: P45055
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families