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P45040 (CYSK_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cysteine synthase
Short name=CSase
EC=2.5.1.47
Alternative name(s):
O-acetylserine (thiol)-lyase
Short name=OAS-TL
O-acetylserine sulfhydrylase
Gene names
Name:cysK
Ordered Locus Names:HI_1103
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length316 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

O(3)-acetyl-L-serine + H2S = L-cysteine + acetate.

Cofactor

Pyridoxal phosphate By similarity.

Pathway

Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the cysteine synthase/cystathionine beta-synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 316316Cysteine synthase
PRO_0000167090

Regions

Region177 – 1815Pyridoxal phosphate binding By similarity

Sites

Binding site71Allosteric inhibitor By similarity
Binding site721Pyridoxal phosphate By similarity
Binding site2681Allosteric inhibitor; via amide nitrogen By similarity
Binding site2721Pyridoxal phosphate By similarity

Amino acid modifications

Modified residue421N6-(pyridoxal phosphate)lysine By similarity

Secondary structure

1 ........................................................... 316
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P45040 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: CA753FC79BBD05BD

FASTA31633,384
        10         20         30         40         50         60 
MAIYADNSYS IGNTPLVRLK HFGHNGNVVV KIEGRNPSYS VKCRIGANMV WQAEKDGTLT 

        70         80         90        100        110        120 
KGKEIVDATS GNTGIALAYV AAARGYKITL TMPETMSLER KRLLCGLGVN LVLTEGAKGM 

       130        140        150        160        170        180 
KGAIAKAEEI VASDPSRYVM LKQFENPANP QIHRETTGPE IWKDTDGKVD VVVAGVGTGG 

       190        200        210        220        230        240 
SITGISRAIK LDFGKQITSV AVEPVESPVI SQTLAGEEVK PGPHKIQGIG AGFIPKNLDL 

       250        260        270        280        290        300 
SIIDRVETVD SDTALATARR LMAEEGILAG ISSGAAVAAA DRLAKLPEFA DKLIVVILPS 

       310 
ASERYLSTAL FEGIEG

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L42023 Genomic DNA. Translation: AAC22758.1.
PIRF64182.
RefSeqNP_439260.1. NC_000907.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1Y7LX-ray1.55A1-316[»]
3IQGX-ray1.90X1-316[»]
3IQHX-ray1.90X1-316[»]
3IQIX-ray1.70X1-316[»]
ProteinModelPortalP45040.
SMRP45040. Positions 2-311.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID950077.
GenomeReviewsGene locus HI_1103 in contig L42023_GR.
KEGGhin:HI1103.
NMPDRfig|71421.1.peg.1060.
PATRIC20190873. VBIHaeInf48452_1149.
TIGRHI_1103.

Phylogenomic databases

HOGENOMHBG748215.
OMADPSRYVM.
ProtClustDBCLSK870576.

Enzyme and pathway databases

BioCycHINF71421:HI_1103-MONOMER.

Family and domain databases

InterProIPR001216. Cys_synth_BS.
IPR005856. Cys_synthKM.
IPR005859. CysK.
IPR001926. PyrdxlP-dep_enz_bsu.
[Graphical view]
KOK01738.
PfamPF00291. PALP. 1 hit.
[Graphical view]
SUPFAMSSF53686. PyrdxlP-dep_enz_bsu. 1 hit.
TIGRFAMsTIGR01139. CysK. 1 hit.
TIGR01136. CysKM. 1 hit.
PROSITEPS00901. CYS_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCYSK_HAEIN
AccessionPrimary (citable) accession number: P45040
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 25, 2012
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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