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P45038

- DSBE_HAEIN

UniProt

P45038 - DSBE_HAEIN

Protein

Thiol:disulfide interchange protein DsbE

Gene

dsbE

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Involved in disulfide bond formation. Catalyzes a late, reductive step in the assembly of periplasmic c-type cytochromes, probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme. Possible subunit of a heme lyase By similarity.By similarity

    GO - Molecular functioni

    1. disulfide oxidoreductase activity Source: InterPro

    GO - Biological processi

    1. cell redox homeostasis Source: InterPro
    2. cytochrome complex assembly Source: UniProtKB-KW

    Keywords - Biological processi

    Cytochrome c-type biogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thiol:disulfide interchange protein DsbE
    Alternative name(s):
    Cytochrome c biogenesis protein CcmG
    Gene namesi
    Name:dsbE
    Synonyms:ccmG
    Ordered Locus Names:HI_1095
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    Subcellular locationi

    Cell inner membrane By similarity; Single-pass membrane protein By similarity; Periplasmic side By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. outer membrane-bounded periplasmic space Source: InterPro
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 181181Thiol:disulfide interchange protein DsbEPRO_0000201295Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi78 ↔ 81Redox-activePROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Protein-protein interaction databases

    STRINGi71421.HI1095.

    Structurei

    3D structure databases

    ProteinModelPortaliP45038.
    SMRiP45038. Positions 54-181.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 44CytoplasmicSequence Analysis
    Topological domaini24 – 181158PeriplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei5 – 2319HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini38 – 175138ThioredoxinPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the thioredoxin family. DsbE subfamily.Curated
    Contains 1 thioredoxin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Redox-active center, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0526.
    KOiK02199.
    OMAiKWLAEFH.
    OrthoDBiEOG6WX4Q5.
    PhylomeDBiP45038.

    Family and domain databases

    Gene3Di3.40.30.10. 1 hit.
    InterProiIPR004799. Periplasmic_diS_OxRdtase_DsbE.
    IPR013740. Redoxin.
    IPR012336. Thioredoxin-like_fold.
    IPR017937. Thioredoxin_CS.
    [Graphical view]
    PfamiPF08534. Redoxin. 1 hit.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 1 hit.
    TIGRFAMsiTIGR00385. dsbE. 1 hit.
    PROSITEiPS00194. THIOREDOXIN_1. 1 hit.
    PS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P45038-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKKLLVPLI LFLSITIAFL VQLKRNAQGE DIKALESALV GKPVPAKNLT    50
    ELFENKTYTN ELFQQGEPVL LNVWATWCPT CYAEHQYLNK LAKEGVRIIG 100
    LDYKDESPKA MKWLKDLGNP YQVVLKDEKG SFGLDLGVYG APETFIVDGK 150
    GVIHYRYAGD VNEKVWTQTL KPIYDKLSEQ Q 181
    Length:181
    Mass (Da):20,535
    Last modified:November 1, 1995 - v1
    Checksum:i4B334B444179EF24
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22752.1.
    PIRiB64167.
    RefSeqiNP_439252.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC22752; AAC22752; HI_1095.
    GeneIDi950067.
    KEGGihin:HI1095.
    PATRICi20190855. VBIHaeInf48452_1140.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22752.1 .
    PIRi B64167.
    RefSeqi NP_439252.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P45038.
    SMRi P45038. Positions 54-181.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI1095.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC22752 ; AAC22752 ; HI_1095 .
    GeneIDi 950067.
    KEGGi hin:HI1095.
    PATRICi 20190855. VBIHaeInf48452_1140.

    Phylogenomic databases

    eggNOGi COG0526.
    KOi K02199.
    OMAi KWLAEFH.
    OrthoDBi EOG6WX4Q5.
    PhylomeDBi P45038.

    Family and domain databases

    Gene3Di 3.40.30.10. 1 hit.
    InterProi IPR004799. Periplasmic_diS_OxRdtase_DsbE.
    IPR013740. Redoxin.
    IPR012336. Thioredoxin-like_fold.
    IPR017937. Thioredoxin_CS.
    [Graphical view ]
    Pfami PF08534. Redoxin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 1 hit.
    TIGRFAMsi TIGR00385. dsbE. 1 hit.
    PROSITEi PS00194. THIOREDOXIN_1. 1 hit.
    PS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiDSBE_HAEIN
    AccessioniPrimary (citable) accession number: P45038
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3