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P45038

- DSBE_HAEIN

UniProt

P45038 - DSBE_HAEIN

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Protein

Thiol:disulfide interchange protein DsbE

Gene
dsbE, ccmG, HI_1095
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in disulfide bond formation. Catalyzes a late, reductive step in the assembly of periplasmic c-type cytochromes, probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme. Possible subunit of a heme lyase By similarity.

GO - Molecular functioni

  1. disulfide oxidoreductase activity Source: InterPro

GO - Biological processi

  1. cell redox homeostasis Source: InterPro
  2. cytochrome complex assembly Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cytochrome c-type biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Thiol:disulfide interchange protein DsbE
Alternative name(s):
Cytochrome c biogenesis protein CcmG
Gene namesi
Name:dsbE
Synonyms:ccmG
Ordered Locus Names:HI_1095
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 44Cytoplasmic Reviewed prediction
Transmembranei5 – 2319Helical; Reviewed predictionAdd
BLAST
Topological domaini24 – 181158Periplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. outer membrane-bounded periplasmic space Source: InterPro
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 181181Thiol:disulfide interchange protein DsbEPRO_0000201295Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi78 ↔ 81Redox-active By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi71421.HI1095.

Structurei

3D structure databases

ProteinModelPortaliP45038.
SMRiP45038. Positions 54-181.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 175138ThioredoxinAdd
BLAST

Sequence similaritiesi

Contains 1 thioredoxin domain.

Keywords - Domaini

Redox-active center, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0526.
KOiK02199.
OMAiKWLAEFH.
OrthoDBiEOG6WX4Q5.
PhylomeDBiP45038.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR004799. Periplasmic_diS_OxRdtase_DsbE.
IPR013740. Redoxin.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
[Graphical view]
PfamiPF08534. Redoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR00385. dsbE. 1 hit.
PROSITEiPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P45038-1 [UniParc]FASTAAdd to Basket

« Hide

MKKKLLVPLI LFLSITIAFL VQLKRNAQGE DIKALESALV GKPVPAKNLT    50
ELFENKTYTN ELFQQGEPVL LNVWATWCPT CYAEHQYLNK LAKEGVRIIG 100
LDYKDESPKA MKWLKDLGNP YQVVLKDEKG SFGLDLGVYG APETFIVDGK 150
GVIHYRYAGD VNEKVWTQTL KPIYDKLSEQ Q 181
Length:181
Mass (Da):20,535
Last modified:November 1, 1995 - v1
Checksum:i4B334B444179EF24
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22752.1.
PIRiB64167.
RefSeqiNP_439252.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22752; AAC22752; HI_1095.
GeneIDi950067.
KEGGihin:HI1095.
PATRICi20190855. VBIHaeInf48452_1140.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22752.1 .
PIRi B64167.
RefSeqi NP_439252.1. NC_000907.1.

3D structure databases

ProteinModelPortali P45038.
SMRi P45038. Positions 54-181.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI1095.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC22752 ; AAC22752 ; HI_1095 .
GeneIDi 950067.
KEGGi hin:HI1095.
PATRICi 20190855. VBIHaeInf48452_1140.

Phylogenomic databases

eggNOGi COG0526.
KOi K02199.
OMAi KWLAEFH.
OrthoDBi EOG6WX4Q5.
PhylomeDBi P45038.

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR004799. Periplasmic_diS_OxRdtase_DsbE.
IPR013740. Redoxin.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
[Graphical view ]
Pfami PF08534. Redoxin. 1 hit.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 1 hit.
TIGRFAMsi TIGR00385. dsbE. 1 hit.
PROSITEi PS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiDSBE_HAEIN
AccessioniPrimary (citable) accession number: P45038
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi