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P45038 (DSBE_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thiol:disulfide interchange protein DsbE
Alternative name(s):
Cytochrome c biogenesis protein CcmG
Gene names
Name:dsbE
Synonyms:ccmG
Ordered Locus Names:HI_1095
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length181 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in disulfide bond formation. Catalyzes a late, reductive step in the assembly of periplasmic c-type cytochromes, probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme. Possible subunit of a heme lyase By similarity.

Subcellular location

Cell inner membrane; Single-pass membrane protein; Periplasmic side By similarity.

Sequence similarities

Belongs to the thioredoxin family. DsbE subfamily.

Contains 1 thioredoxin domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 181181Thiol:disulfide interchange protein DsbE
PRO_0000201295

Regions

Topological domain1 – 44Cytoplasmic Potential
Transmembrane5 – 2319Helical; Potential
Topological domain24 – 181158Periplasmic Potential
Domain38 – 175138Thioredoxin

Amino acid modifications

Disulfide bond78 ↔ 81Redox-active By similarity

Sequences

Sequence LengthMass (Da)Tools
P45038 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 4B334B444179EF24

FASTA18120,535
        10         20         30         40         50         60 
MKKKLLVPLI LFLSITIAFL VQLKRNAQGE DIKALESALV GKPVPAKNLT ELFENKTYTN 

        70         80         90        100        110        120 
ELFQQGEPVL LNVWATWCPT CYAEHQYLNK LAKEGVRIIG LDYKDESPKA MKWLKDLGNP 

       130        140        150        160        170        180 
YQVVLKDEKG SFGLDLGVYG APETFIVDGK GVIHYRYAGD VNEKVWTQTL KPIYDKLSEQ 


Q 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC22752.1.
PIRB64167.
RefSeqNP_439252.1. NC_000907.1.

3D structure databases

ProteinModelPortalP45038.
SMRP45038. Positions 54-181.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI1095.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC22752; AAC22752; HI_1095.
GeneID950067.
KEGGhin:HI1095.
PATRIC20190855. VBIHaeInf48452_1140.

Phylogenomic databases

eggNOGCOG0526.
KOK02199.
OMAKWLAEFH.
OrthoDBEOG6WX4Q5.
PhylomeDBP45038.

Family and domain databases

Gene3D3.40.30.10. 1 hit.
InterProIPR004799. Periplasmic_diS_OxRdtase_DsbE.
IPR013740. Redoxin.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
[Graphical view]
PfamPF08534. Redoxin. 1 hit.
[Graphical view]
SUPFAMSSF52833. SSF52833. 1 hit.
TIGRFAMsTIGR00385. dsbE. 1 hit.
PROSITEPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDSBE_HAEIN
AccessionPrimary (citable) accession number: P45038
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names