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P45038

- DSBE_HAEIN

UniProt

P45038 - DSBE_HAEIN

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Protein

Thiol:disulfide interchange protein DsbE

Gene

dsbE

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in disulfide bond formation. Catalyzes a late, reductive step in the assembly of periplasmic c-type cytochromes, probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme. Possible subunit of a heme lyase By similarity.By similarity

GO - Molecular functioni

  1. disulfide oxidoreductase activity Source: InterPro

GO - Biological processi

  1. cell redox homeostasis Source: InterPro
  2. cytochrome complex assembly Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cytochrome c-type biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Thiol:disulfide interchange protein DsbE
Alternative name(s):
Cytochrome c biogenesis protein CcmG
Gene namesi
Name:dsbE
Synonyms:ccmG
Ordered Locus Names:HI_1095
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

Subcellular locationi

Cell inner membrane By similarity; Single-pass membrane protein By similarity; Periplasmic side By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. outer membrane-bounded periplasmic space Source: InterPro
  3. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 181181Thiol:disulfide interchange protein DsbEPRO_0000201295Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi78 ↔ 81Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi71421.HI1095.

Structurei

3D structure databases

ProteinModelPortaliP45038.
SMRiP45038. Positions 54-181.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 44CytoplasmicSequence Analysis
Topological domaini24 – 181158PeriplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2319HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 175138ThioredoxinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the thioredoxin family. DsbE subfamily.Curated
Contains 1 thioredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0526.
KOiK02199.
OMAiKWLAEFH.
OrthoDBiEOG6WX4Q5.
PhylomeDBiP45038.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR004799. Periplasmic_diS_OxRdtase_DsbE.
IPR013740. Redoxin.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
[Graphical view]
PfamiPF08534. Redoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR00385. dsbE. 1 hit.
PROSITEiPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P45038-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKKLLVPLI LFLSITIAFL VQLKRNAQGE DIKALESALV GKPVPAKNLT
60 70 80 90 100
ELFENKTYTN ELFQQGEPVL LNVWATWCPT CYAEHQYLNK LAKEGVRIIG
110 120 130 140 150
LDYKDESPKA MKWLKDLGNP YQVVLKDEKG SFGLDLGVYG APETFIVDGK
160 170 180
GVIHYRYAGD VNEKVWTQTL KPIYDKLSEQ Q
Length:181
Mass (Da):20,535
Last modified:November 1, 1995 - v1
Checksum:i4B334B444179EF24
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22752.1.
PIRiB64167.
RefSeqiNP_439252.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22752; AAC22752; HI_1095.
GeneIDi950067.
KEGGihin:HI1095.
PATRICi20190855. VBIHaeInf48452_1140.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22752.1 .
PIRi B64167.
RefSeqi NP_439252.1. NC_000907.1.

3D structure databases

ProteinModelPortali P45038.
SMRi P45038. Positions 54-181.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI1095.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC22752 ; AAC22752 ; HI_1095 .
GeneIDi 950067.
KEGGi hin:HI1095.
PATRICi 20190855. VBIHaeInf48452_1140.

Phylogenomic databases

eggNOGi COG0526.
KOi K02199.
OMAi KWLAEFH.
OrthoDBi EOG6WX4Q5.
PhylomeDBi P45038.

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR004799. Periplasmic_diS_OxRdtase_DsbE.
IPR013740. Redoxin.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
[Graphical view ]
Pfami PF08534. Redoxin. 1 hit.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 1 hit.
TIGRFAMsi TIGR00385. dsbE. 1 hit.
PROSITEi PS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiDSBE_HAEIN
AccessioniPrimary (citable) accession number: P45038
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3