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Protein

Heme exporter protein B

Gene

ccmB

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.By similarity

GO - Molecular functioni

  1. heme transporter activity Source: InterPro

GO - Biological processi

  1. cytochrome complex assembly Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cytochrome c-type biogenesis, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Heme exporter protein B
Alternative name(s):
Cytochrome c-type biogenesis protein CcmB
Gene namesi
Name:ccmB
Ordered Locus Names:HI_1090
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei21 – 4121HelicalSequence AnalysisAdd
BLAST
Transmembranei46 – 6621HelicalSequence AnalysisAdd
BLAST
Transmembranei101 – 12121HelicalSequence AnalysisAdd
BLAST
Transmembranei126 – 14621HelicalSequence AnalysisAdd
BLAST
Transmembranei157 – 17721HelicalSequence AnalysisAdd
BLAST
Transmembranei193 – 21321HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 221221Heme exporter protein BPRO_0000201542Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI1090.

Family & Domainsi

Sequence similaritiesi

Belongs to the CcmB/CycW/HelB family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2386.
KOiK02194.
OMAiGPAIVWI.
OrthoDBiEOG64FKHN.
PhylomeDBiP45033.

Family and domain databases

InterProiIPR003544. Cyt_c_biogenesis_CcmB.
IPR026031. Cyt_c_CcmB_bac.
[Graphical view]
PANTHERiPTHR30070:SF1. PTHR30070:SF1. 1 hit.
PfamiPF03379. CcmB. 1 hit.
[Graphical view]
PIRSFiPIRSF002764. CcmB. 1 hit.
PRINTSiPR01414. CCMBBIOGNSIS.
TIGRFAMsiTIGR01190. ccmB. 1 hit.

Sequencei

Sequence statusi: Complete.

P45033-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIFLEIIKRE LQIAMRKNAE ILNPLWFFLL VITLFPLVIG PDPKLLSRIA
60 70 80 90 100
PGIAWVAALL SALLSFERLF RDDFIDGSLE QLMLTAQPLP MTALAKVVAH
110 120 130 140 150
WLLTGLPLIL LSPIAALLLS LEVNIWWALV LTLLLGTPVL SCIGAIGVAL
160 170 180 190 200
TVGLRKGGVL LSLLVVPLFI PVLIFASSVL EAAGLNVPYG GQLAILGAMM
210 220
VGAVTLSPFA IAAALRISLD N
Length:221
Mass (Da):23,644
Last modified:October 31, 1995 - v1
Checksum:i2FF8EAFDC5228EF8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22747.1.
PIRiF64166.
RefSeqiNP_439247.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22747; AAC22747; HI_1090.
GeneIDi950092.
KEGGihin:HI1090.
PATRICi20190845. VBIHaeInf48452_1135.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22747.1.
PIRiF64166.
RefSeqiNP_439247.1. NC_000907.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI1090.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC22747; AAC22747; HI_1090.
GeneIDi950092.
KEGGihin:HI1090.
PATRICi20190845. VBIHaeInf48452_1135.

Phylogenomic databases

eggNOGiCOG2386.
KOiK02194.
OMAiGPAIVWI.
OrthoDBiEOG64FKHN.
PhylomeDBiP45033.

Family and domain databases

InterProiIPR003544. Cyt_c_biogenesis_CcmB.
IPR026031. Cyt_c_CcmB_bac.
[Graphical view]
PANTHERiPTHR30070:SF1. PTHR30070:SF1. 1 hit.
PfamiPF03379. CcmB. 1 hit.
[Graphical view]
PIRSFiPIRSF002764. CcmB. 1 hit.
PRINTSiPR01414. CCMBBIOGNSIS.
TIGRFAMsiTIGR01190. ccmB. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiCCMB_HAEIN
AccessioniPrimary (citable) accession number: P45033
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 1995
Last sequence update: October 31, 1995
Last modified: January 6, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.