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P45032 (CCMA_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c biogenesis ATP-binding export protein CcmA

EC=3.6.3.41
Alternative name(s):
Heme exporter protein A
Gene names
Name:ccmA
Ordered Locus Names:HI_1089
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length212 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system By similarity.

Catalytic activity

ATP + H2O + heme(In) = ADP + phosphate + heme(Out).

Subunit structure

The complex is composed of two ATP-binding proteins (CcmA) and two transmembrane proteins (CcmB) By similarity.

Subcellular location

Cell inner membrane; Peripheral membrane protein By similarity.

Sequence similarities

Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. [View classification]

Contains 1 ABC transporter domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 212212Cytochrome c biogenesis ATP-binding export protein CcmA
PRO_0000092182

Regions

Domain7 – 209203ABC transporter
Nucleotide binding39 – 468ATP Potential

Sequences

Sequence LengthMass (Da)Tools
P45032 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: BEDD2B7F3CE633D2

FASTA21224,009
        10         20         30         40         50         60 
MFEQHKLSLQ NLSCQRGERV LFRALTCDFN SGDFVQIEGH NGIGKTSLLR ILAGLVRPLE 

        70         80         90        100        110        120 
GEVRWDSEAI SKQREQYHQN LLYLGHLSGV KPELTAWENL QFYQRISQAE QNTDMLWDLL 

       130        140        150        160        170        180 
EKVGLLGRED LPAAQLSAGQ QKRIALGRLW LSQAPLWILD EPFTAIDKKG VEILTALFDE 

       190        200        210 
HAQRGGIVLL TSHQEVPSSH LQKLNLAAYK AE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC22746.1.
PIRE64166.
RefSeqNP_439246.1. NC_000907.1.

3D structure databases

ProteinModelPortalP45032.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI1089.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC22746; AAC22746; HI_1089.
GeneID949617.
KEGGhin:HI1089.
PATRIC20190843. VBIHaeInf48452_1134.

Phylogenomic databases

eggNOGCOG4133.
KOK02193.
OMAVTIDISQ.
OrthoDBEOG6SNDS1.
ProtClustDBPRK13538.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR005895. ABC_transptr_haem_export_CcmA.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR01189. ccmA. 1 hit.
PROSITEPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51243. CCMA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCCMA_HAEIN
AccessionPrimary (citable) accession number: P45032
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names