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P45032

- CCMA_HAEIN

UniProt

P45032 - CCMA_HAEIN

Protein

Cytochrome c biogenesis ATP-binding export protein CcmA

Gene

ccmA

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.UniRule annotation

    Catalytic activityi

    ATP + H2O + heme(In) = ADP + phosphate + heme(Out).UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi39 – 468ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. heme-transporting ATPase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cytochrome complex assembly Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Cytochrome c-type biogenesis, Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c biogenesis ATP-binding export protein CcmAUniRule annotation (EC:3.6.3.41UniRule annotation)
    Alternative name(s):
    Heme exporter protein AUniRule annotation
    Gene namesi
    Name:ccmAUniRule annotation
    Ordered Locus Names:HI_1089
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

    GO - Cellular componenti

    1. ATP-binding cassette (ABC) transporter complex Source: UniProtKB-HAMAP
    2. outer membrane-bounded periplasmic space Source: InterPro

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 212212Cytochrome c biogenesis ATP-binding export protein CcmAPRO_0000092182Add
    BLAST

    Interactioni

    Subunit structurei

    The complex is composed of two ATP-binding proteins (CcmA) and two transmembrane proteins (CcmB).UniRule annotation

    Protein-protein interaction databases

    STRINGi71421.HI1089.

    Structurei

    3D structure databases

    ProteinModelPortaliP45032.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini7 – 209203ABC transporterUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. [View classification]UniRule annotation
    Contains 1 ABC transporter domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG4133.
    KOiK02193.
    OMAiVPLWILD.
    OrthoDBiEOG6SNDS1.
    PhylomeDBiP45032.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR003593. AAA+_ATPase.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR005895. ABC_transptr_haem_export_CcmA.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00005. ABC_tran. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR01189. ccmA. 1 hit.
    PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 1 hit.
    PS51243. CCMA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P45032-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFEQHKLSLQ NLSCQRGERV LFRALTCDFN SGDFVQIEGH NGIGKTSLLR    50
    ILAGLVRPLE GEVRWDSEAI SKQREQYHQN LLYLGHLSGV KPELTAWENL 100
    QFYQRISQAE QNTDMLWDLL EKVGLLGRED LPAAQLSAGQ QKRIALGRLW 150
    LSQAPLWILD EPFTAIDKKG VEILTALFDE HAQRGGIVLL TSHQEVPSSH 200
    LQKLNLAAYK AE 212
    Length:212
    Mass (Da):24,009
    Last modified:November 1, 1995 - v1
    Checksum:iBEDD2B7F3CE633D2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22746.1.
    PIRiE64166.
    RefSeqiNP_439246.1. NC_000907.1.
    WP_005693414.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC22746; AAC22746; HI_1089.
    GeneIDi949617.
    KEGGihin:HI1089.
    PATRICi20190843. VBIHaeInf48452_1134.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22746.1 .
    PIRi E64166.
    RefSeqi NP_439246.1. NC_000907.1.
    WP_005693414.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P45032.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI1089.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC22746 ; AAC22746 ; HI_1089 .
    GeneIDi 949617.
    KEGGi hin:HI1089.
    PATRICi 20190843. VBIHaeInf48452_1134.

    Phylogenomic databases

    eggNOGi COG4133.
    KOi K02193.
    OMAi VPLWILD.
    OrthoDBi EOG6SNDS1.
    PhylomeDBi P45032.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR003593. AAA+_ATPase.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR005895. ABC_transptr_haem_export_CcmA.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00005. ABC_tran. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR01189. ccmA. 1 hit.
    PROSITEi PS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 1 hit.
    PS51243. CCMA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiCCMA_HAEIN
    AccessioniPrimary (citable) accession number: P45032
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3