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P45032

- CCMA_HAEIN

UniProt

P45032 - CCMA_HAEIN

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Protein
Cytochrome c biogenesis ATP-binding export protein CcmA
Gene
ccmA, HI_1089
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system By similarity.

Catalytic activityi

ATP + H2O + heme(In) = ADP + phosphate + heme(Out).

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi39 – 468ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. heme-transporting ATPase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. cytochrome complex assembly Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Cytochrome c-type biogenesis, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c biogenesis ATP-binding export protein CcmA (EC:3.6.3.41)
Alternative name(s):
Heme exporter protein A
Gene namesi
Name:ccmA
Ordered Locus Names:HI_1089
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. ATP-binding cassette (ABC) transporter complex Source: UniProtKB-HAMAP
  2. outer membrane-bounded periplasmic space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 212212Cytochrome c biogenesis ATP-binding export protein CcmA
PRO_0000092182Add
BLAST

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (CcmA) and two transmembrane proteins (CcmB) By similarity.

Protein-protein interaction databases

STRINGi71421.HI1089.

Structurei

3D structure databases

ProteinModelPortaliP45032.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 209203ABC transporter
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG4133.
KOiK02193.
OMAiVPLWILD.
OrthoDBiEOG6SNDS1.
PhylomeDBiP45032.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR005895. ABC_transptr_haem_export_CcmA.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01189. ccmA. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51243. CCMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P45032-1 [UniParc]FASTAAdd to Basket

« Hide

MFEQHKLSLQ NLSCQRGERV LFRALTCDFN SGDFVQIEGH NGIGKTSLLR    50
ILAGLVRPLE GEVRWDSEAI SKQREQYHQN LLYLGHLSGV KPELTAWENL 100
QFYQRISQAE QNTDMLWDLL EKVGLLGRED LPAAQLSAGQ QKRIALGRLW 150
LSQAPLWILD EPFTAIDKKG VEILTALFDE HAQRGGIVLL TSHQEVPSSH 200
LQKLNLAAYK AE 212
Length:212
Mass (Da):24,009
Last modified:November 1, 1995 - v1
Checksum:iBEDD2B7F3CE633D2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22746.1.
PIRiE64166.
RefSeqiNP_439246.1. NC_000907.1.
WP_005693414.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22746; AAC22746; HI_1089.
GeneIDi949617.
KEGGihin:HI1089.
PATRICi20190843. VBIHaeInf48452_1134.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22746.1 .
PIRi E64166.
RefSeqi NP_439246.1. NC_000907.1.
WP_005693414.1. NC_000907.1.

3D structure databases

ProteinModelPortali P45032.
ModBasei Search...

Protein-protein interaction databases

STRINGi 71421.HI1089.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC22746 ; AAC22746 ; HI_1089 .
GeneIDi 949617.
KEGGi hin:HI1089.
PATRICi 20190843. VBIHaeInf48452_1134.

Phylogenomic databases

eggNOGi COG4133.
KOi K02193.
OMAi VPLWILD.
OrthoDBi EOG6SNDS1.
PhylomeDBi P45032.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR005895. ABC_transptr_haem_export_CcmA.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00005. ABC_tran. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR01189. ccmA. 1 hit.
PROSITEi PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51243. CCMA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiCCMA_HAEIN
AccessioniPrimary (citable) accession number: P45032
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 3, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi