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P45016

- NRFB_HAEIN

UniProt

P45016 - NRFB_HAEIN

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Protein

Cytochrome c-type protein NrfB

Gene

nrfB

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Plays a role in nitrite reduction.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei65 – 651Heme 1 (covalent)By similarity
Binding sitei68 – 681Heme 1 (covalent)By similarity
Metal bindingi69 – 691Iron (heme 1 axial ligand)By similarity
Binding sitei110 – 1101Heme 2 (covalent)By similarity
Binding sitei113 – 1131Heme 2 (covalent)By similarity
Metal bindingi114 – 1141Iron (heme 2 axial ligand)By similarity
Binding sitei152 – 1521Heme 3 (covalent)By similarity
Binding sitei155 – 1551Heme 3 (covalent)By similarity
Metal bindingi156 – 1561Iron (heme 3 axial ligand)By similarity
Binding sitei177 – 1771Heme 4 (covalent)By similarity
Binding sitei180 – 1801Heme 4 (covalent)By similarity
Metal bindingi181 – 1811Iron (heme 4 axial ligand)By similarity
Binding sitei202 – 2021Heme 5 (covalent)By similarity
Binding sitei205 – 2051Heme 5 (covalent)By similarity
Metal bindingi206 – 2061Iron (heme 5 axial ligand)By similarity

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. nitrogen compound metabolic process Source: UniProtKB-UniPathway
  2. oxidation-reduction process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00045.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c-type protein NrfB
Gene namesi
Name:nrfB
Ordered Locus Names:HI_1068
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

Subcellular locationi

Periplasm Curated

GO - Cellular componenti

  1. periplasmic space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3939Sequence AnalysisAdd
BLAST
Chaini40 – 226187Cytochrome c-type protein NrfBPRO_0000006586Add
BLAST

Post-translational modificationi

Binds 5 heme groups per subunit.By similarity

Interactioni

Protein-protein interaction databases

STRINGi71421.HI1068.

Structurei

3D structure databases

ProteinModelPortaliP45016.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG06663.
KOiK04013.
OMAiQEQNQVC.
OrthoDBiEOG62ZHTD.

Family and domain databases

InterProiIPR017564. Cyt_c_NO2Rdtase_pentahaem-su.
IPR011031. Multihaem_cyt.
[Graphical view]
TIGRFAMsiTIGR03146. cyt_nit_nrfB. 1 hit.
PROSITEiPS51008. MULTIHEME_CYTC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P45016-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIFKVKFEVT QMILTSLINK SAKALVIVAF VAAPFLAHAD DAQKPAVHVT
60 70 80 90 100
YEPQLDNQRD PNQYCAKCHK FDKIDKNQTL DQSGGELHFG KFHGAHLDKK
110 120 130 140 150
NPNNGKAITC VSCHGNISEN HRRGAKDVMR FEGDIFGNKK PMYSVQEQNQ
160 170 180 190 200
VCFACHQPDK LREKLWAHDV HAMKLPCASC HTLHPKEDAM KGIQPKQRVK
210 220
LCVDCHGEQQ KRKAEQDKLI EQKDKL
Length:226
Mass (Da):25,664
Last modified:November 1, 1995 - v1
Checksum:i959F2DCEA668030A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22726.1.
PIRiB64181.
RefSeqiNP_439226.2. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22726; AAC22726; HI_1068.
GeneIDi950046.
KEGGihin:HI1068.
PATRICi20190799. VBIHaeInf48452_1112.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22726.1 .
PIRi B64181.
RefSeqi NP_439226.2. NC_000907.1.

3D structure databases

ProteinModelPortali P45016.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI1068.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC22726 ; AAC22726 ; HI_1068 .
GeneIDi 950046.
KEGGi hin:HI1068.
PATRICi 20190799. VBIHaeInf48452_1112.

Phylogenomic databases

eggNOGi NOG06663.
KOi K04013.
OMAi QEQNQVC.
OrthoDBi EOG62ZHTD.

Enzyme and pathway databases

UniPathwayi UPA00045 .

Family and domain databases

InterProi IPR017564. Cyt_c_NO2Rdtase_pentahaem-su.
IPR011031. Multihaem_cyt.
[Graphical view ]
TIGRFAMsi TIGR03146. cyt_nit_nrfB. 1 hit.
PROSITEi PS51008. MULTIHEME_CYTC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiNRFB_HAEIN
AccessioniPrimary (citable) accession number: P45016
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways

External Data

Dasty 3