P45015 (NRFC_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein NrfC homolog

Gene names

Name:	nrfC
Ordered Locus Names:	HI_1067

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]

Taxonomic identifier

71421 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus › Haemophilus influenzae

Protein attributes

Sequence length	225 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Probably involved in the transfer of electrons from the quinone pool to the type-c cytochromes By similarity.
Post-translational modification	Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.
Sequence similarities	Contains 3 4Fe-4S ferredoxin-type domains.

Ontologies

Keywords
Biological process	Electron transport Transport
Domain	Repeat Signal
Ligand	4Fe-4S Iron Iron-sulfur Metal-binding
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW electron carrier activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 28	28	Tat-type signal Potential
	Chain	29 – 225	197	Protein NrfC homolog		PRO_0000008846
Regions
	Domain	39 – 67	29	4Fe-4S ferredoxin-type 1
	Domain	85 – 116	32	4Fe-4S ferredoxin-type 2
	Domain	118 – 147	30	4Fe-4S ferredoxin-type 3
Sites
	Metal binding	48	1	Iron-sulfur 1 (4Fe-4S) By similarity
	Metal binding	51	1	Iron-sulfur 1 (4Fe-4S) By similarity
	Metal binding	54	1	Iron-sulfur 1 (4Fe-4S) By similarity
	Metal binding	58	1	Iron-sulfur 2 (4Fe-4S) By similarity
	Metal binding	94	1	Iron-sulfur 3 (4Fe-4S) By similarity
	Metal binding	97	1	Iron-sulfur 3 (4Fe-4S) By similarity
	Metal binding	102	1	Iron-sulfur 3 (4Fe-4S) By similarity
	Metal binding	106	1	Iron-sulfur 4 (4Fe-4S) By similarity
	Metal binding	127	1	Iron-sulfur 4 (4Fe-4S) By similarity
	Metal binding	130	1	Iron-sulfur 4 (4Fe-4S) By similarity
	Metal binding	133	1	Iron-sulfur 4 (4Fe-4S) By similarity
	Metal binding	137	1	Iron-sulfur 3 (4Fe-4S) By similarity
	Metal binding	154	1	Iron-sulfur 2 (4Fe-4S) By similarity
	Metal binding	157	1	Iron-sulfur 2 (4Fe-4S) By similarity
	Metal binding	170	1	Iron-sulfur 2 (4Fe-4S) By similarity
	Metal binding	174	1	Iron-sulfur 1 (4Fe-4S) By similarity

Sequences

	Sequence		Length	Mass (Da)
	P45015 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: F2E28CA9C9471CAB	FASTA	225	25,105
	10 20 30 40 50 60 MTVCSRRNFV SGMGAVILMT GTSLPAFAKE NKADKPKRYA MIHDENACIG CTACMDSCRD 70 80 90 100 110 120 VNQVPEGVSR LEILRSEPYG EFPNQEYEFF RQSCQHCTNA PCVAVCPTGA SFIDKETGIV 130 140 150 160 170 180 DVHKDLCIGC QYCIAVCPYR VRFIHPIHRT ADKCNFCRDT NLANGKQPAC VEACPTKALT 190 200 210 220 FGDMNDPTSA VSRKVKEKPV YRTKVELGTQ PNLYHIPFQH GEPRR

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L42023 Genomic DNA. Translation: AAC22725.1.
PIR	A64181.
RefSeq	NP_439225.1. NC_000907.1.
3D structure databases
ProteinModelPortal	P45015.
ModBase	Search...
Protein-protein interaction databases
STRING	71421.HI1067.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC22725; AAC22725; HI_1067.
GeneID	950045.
KEGG	hin:HI1067.
PATRIC	20190797. VBIHaeInf48452_1111.
Phylogenomic databases
eggNOG	COG0437.
KO	K04014.
OMA	SCSRRNF.
ProtClustDB	CLSK869937.
Family and domain databases
InterPro	IPR001450. 4Fe4S-bd_dom. IPR017896. 4Fe4S_Fe-S-bd. IPR017900. 4Fe4S_Fe_S_CS. IPR017567. Cyt_c_NO2Rdtase_NrfC. IPR006311. TAT_signal. [Graphical view]
Pfam	PF00037. Fer4. 1 hit. PF12798. Fer4_3. 1 hit. PF12838. Fer4_7. 1 hit. [Graphical view]
TIGRFAMs	TIGR03149. cyt_nit_nrfC. 1 hit.
PROSITE	PS00198. 4FE4S_FER_1. 1 hit. PS51379. 4FE4S_FER_2. 3 hits. PS51318. TAT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NRFC_HAEIN

Accession

Primary (citable) accession number: P45015

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	May 1, 2013
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program