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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:HI_1060
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 390390Lipid-A-disaccharide synthasePRO_0000190168Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI1060.

Structurei

3D structure databases

ProteinModelPortaliP45011.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.Curated

Phylogenomic databases

eggNOGiCOG0763.
KOiK00748.
OMAiAPQEWAW.
OrthoDBiEOG6FBWZR.
PhylomeDBiP45011.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

P45011-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNKTNPTIAL VAGEVSGDIL GAGLIRQLKA HYPNARFIGI AGPRMLAEGC
60 70 80 90 100
ETLVDMEELS VMGLAEILKH LPRLLKIRKN VIQTMLQEKP DVYIGIDAPD
110 120 130 140 150
FNLDVELKLK ANGIKTIHYV SPSVWAWRQN RIHKIAKATH QVLAFLPFEK
160 170 180 190 200
AFYDKFNVPC RFIGHTMADA IPLKPNRAEA CQTLQIDPAQ RYLAILVGSR
210 220 230 240 250
GSEVEFLAEP FLKTALLLKE QFPDLQFLVP LVNEKRRIQF ETIKAKITPN
260 270 280 290 300
LDLHLIDGNA RQAMIAADAT LLASGTAALE AMLCKSPMVV GYRMKPLTYF
310 320 330 340 350
LAKRLVKTDY ISLPNLLANE MLVPEMIQEE CTPELLAEKL SVYLSDDESA
360 370 380 390
VKNRHVLIQH FTDLHQKIQC NADKQAAQAV IDLLEGKENV
Length:390
Mass (Da):43,637
Last modified:November 1, 1997 - v2
Checksum:i690BEC98ECFEECCD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti342 – 3421V → A in CAA60866. (PubMed:8917090)Curated
Sequence conflicti350 – 3501A → S in CAA60866. (PubMed:8917090)Curated
Sequence conflicti387 – 3882KE → TK in CAA60866. (PubMed:8917090)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22715.1.
X87416 Genomic DNA. Translation: CAA60866.1.
RefSeqiNP_439218.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22715; AAC22715; HI_1060.
GeneIDi950031.
KEGGihin:HI1060.
PATRICi20190783. VBIHaeInf48452_1104.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22715.1.
X87416 Genomic DNA. Translation: CAA60866.1.
RefSeqiNP_439218.1. NC_000907.1.

3D structure databases

ProteinModelPortaliP45011.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI1060.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC22715; AAC22715; HI_1060.
GeneIDi950031.
KEGGihin:HI1060.
PATRICi20190783. VBIHaeInf48452_1104.

Phylogenomic databases

eggNOGiCOG0763.
KOiK00748.
OMAiAPQEWAW.
OrthoDBiEOG6FBWZR.
PhylomeDBiP45011.

Enzyme and pathway databases

UniPathwayiUPA00359; UER00481.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
  2. White O., Clayton R.A., Kerlavage A.R., Fleischmann R.D.
    Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "Cloning and expression of genes encoding lipid A biosynthesis from Haemophilus influenzae type b."
    Servos S., Khan S., Maskell D.
    Gene 175:137-141(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: RM 7004 / Serotype B.

Entry informationi

Entry nameiLPXB_HAEIN
AccessioniPrimary (citable) accession number: P45011
Secondary accession number(s): P94807
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1997
Last modified: February 4, 2015
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.