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P45011

- LPXB_HAEIN

UniProt

P45011 - LPXB_HAEIN

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthase (EC:2.4.1.182)
    Gene namesi
    Name:lpxB
    Ordered Locus Names:HI_1060
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 390390Lipid-A-disaccharide synthasePRO_0000190168Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi71421.HI1060.

    Structurei

    3D structure databases

    ProteinModelPortaliP45011.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.Curated

    Phylogenomic databases

    eggNOGiCOG0763.
    KOiK00748.
    OMAiVSPITYR.
    OrthoDBiEOG6FBWZR.
    PhylomeDBiP45011.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P45011-1 [UniParc]FASTAAdd to Basket

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    MNKTNPTIAL VAGEVSGDIL GAGLIRQLKA HYPNARFIGI AGPRMLAEGC    50
    ETLVDMEELS VMGLAEILKH LPRLLKIRKN VIQTMLQEKP DVYIGIDAPD 100
    FNLDVELKLK ANGIKTIHYV SPSVWAWRQN RIHKIAKATH QVLAFLPFEK 150
    AFYDKFNVPC RFIGHTMADA IPLKPNRAEA CQTLQIDPAQ RYLAILVGSR 200
    GSEVEFLAEP FLKTALLLKE QFPDLQFLVP LVNEKRRIQF ETIKAKITPN 250
    LDLHLIDGNA RQAMIAADAT LLASGTAALE AMLCKSPMVV GYRMKPLTYF 300
    LAKRLVKTDY ISLPNLLANE MLVPEMIQEE CTPELLAEKL SVYLSDDESA 350
    VKNRHVLIQH FTDLHQKIQC NADKQAAQAV IDLLEGKENV 390
    Length:390
    Mass (Da):43,637
    Last modified:November 1, 1997 - v2
    Checksum:i690BEC98ECFEECCD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti342 – 3421V → A in CAA60866. (PubMed:8917090)Curated
    Sequence conflicti350 – 3501A → S in CAA60866. (PubMed:8917090)Curated
    Sequence conflicti387 – 3882KE → TK in CAA60866. (PubMed:8917090)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22715.1.
    X87416 Genomic DNA. Translation: CAA60866.1.
    RefSeqiNP_439218.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC22715; AAC22715; HI_1060.
    GeneIDi950031.
    KEGGihin:HI1060.
    PATRICi20190783. VBIHaeInf48452_1104.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22715.1 .
    X87416 Genomic DNA. Translation: CAA60866.1 .
    RefSeqi NP_439218.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P45011.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI1060.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC22715 ; AAC22715 ; HI_1060 .
    GeneIDi 950031.
    KEGGi hin:HI1060.
    PATRICi 20190783. VBIHaeInf48452_1104.

    Phylogenomic databases

    eggNOGi COG0763.
    KOi K00748.
    OMAi VSPITYR.
    OrthoDBi EOG6FBWZR.
    PhylomeDBi P45011.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
    2. White O., Clayton R.A., Kerlavage A.R., Fleischmann R.D.
      Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    3. "Cloning and expression of genes encoding lipid A biosynthesis from Haemophilus influenzae type b."
      Servos S., Khan S., Maskell D.
      Gene 175:137-141(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: RM 7004 / Serotype B.

    Entry informationi

    Entry nameiLPXB_HAEIN
    AccessioniPrimary (citable) accession number: P45011
    Secondary accession number(s): P94807
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 86 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3