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P45011

- LPXB_HAEIN

UniProt

P45011 - LPXB_HAEIN

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Protein
Lipid-A-disaccharide synthase
Gene
lpxB, HI_1060
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:HI_1060
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 390390Lipid-A-disaccharide synthaseUniRule annotation
PRO_0000190168Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI1060.

Structurei

3D structure databases

ProteinModelPortaliP45011.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.
PhylomeDBiP45011.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

P45011-1 [UniParc]FASTAAdd to Basket

« Hide

MNKTNPTIAL VAGEVSGDIL GAGLIRQLKA HYPNARFIGI AGPRMLAEGC    50
ETLVDMEELS VMGLAEILKH LPRLLKIRKN VIQTMLQEKP DVYIGIDAPD 100
FNLDVELKLK ANGIKTIHYV SPSVWAWRQN RIHKIAKATH QVLAFLPFEK 150
AFYDKFNVPC RFIGHTMADA IPLKPNRAEA CQTLQIDPAQ RYLAILVGSR 200
GSEVEFLAEP FLKTALLLKE QFPDLQFLVP LVNEKRRIQF ETIKAKITPN 250
LDLHLIDGNA RQAMIAADAT LLASGTAALE AMLCKSPMVV GYRMKPLTYF 300
LAKRLVKTDY ISLPNLLANE MLVPEMIQEE CTPELLAEKL SVYLSDDESA 350
VKNRHVLIQH FTDLHQKIQC NADKQAAQAV IDLLEGKENV 390
Length:390
Mass (Da):43,637
Last modified:November 1, 1997 - v2
Checksum:i690BEC98ECFEECCD
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti342 – 3421V → A in CAA60866. 1 Publication
Sequence conflicti350 – 3501A → S in CAA60866. 1 Publication
Sequence conflicti387 – 3882KE → TK in CAA60866. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22715.1.
X87416 Genomic DNA. Translation: CAA60866.1.
RefSeqiNP_439218.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22715; AAC22715; HI_1060.
GeneIDi950031.
KEGGihin:HI1060.
PATRICi20190783. VBIHaeInf48452_1104.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22715.1 .
X87416 Genomic DNA. Translation: CAA60866.1 .
RefSeqi NP_439218.1. NC_000907.1.

3D structure databases

ProteinModelPortali P45011.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI1060.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC22715 ; AAC22715 ; HI_1060 .
GeneIDi 950031.
KEGGi hin:HI1060.
PATRICi 20190783. VBIHaeInf48452_1104.

Phylogenomic databases

eggNOGi COG0763.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.
PhylomeDBi P45011.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
  2. White O., Clayton R.A., Kerlavage A.R., Fleischmann R.D.
    Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "Cloning and expression of genes encoding lipid A biosynthesis from Haemophilus influenzae type b."
    Servos S., Khan S., Maskell D.
    Gene 175:137-141(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: RM 7004 / Serotype B.

Entry informationi

Entry nameiLPXB_HAEIN
AccessioniPrimary (citable) accession number: P45011
Secondary accession number(s): P94807
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1997
Last modified: July 9, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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