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Protein

Modification methylase HindV

Gene

hindVM

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This methylase recognizes the double-stranded sequence GRCGYC, causes specific methylation on C-? on both strands, and protects the DNA from cleavage by the HindV endonuclease.

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei75PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processRestriction system
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciHINF71421:G1GJ1-1080-MONOMER

Protein family/group databases

REBASEi3574 M.HindV

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase HindV (EC:2.1.1.37)
Short name:
M.HindV
Alternative name(s):
Cytosine-specific methyltransferase HindV
Gene namesi
Name:hindVM
Ordered Locus Names:HI_1041
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000878811 – 304Modification methylase HindVAdd BLAST304

Interactioni

Protein-protein interaction databases

STRINGi71421.HI1041

Structurei

3D structure databases

ProteinModelPortaliP45000
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 299SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd BLAST299

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105NI8 Bacteria
COG0270 LUCA
KOiK00558
OMAiCGVPQKR
PhylomeDBiP45000

Family and domain databases

InterProiView protein in InterPro
IPR018117 C5_DNA_meth_AS
IPR001525 C5_MeTfrase
IPR031303 C5_meth_CS
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF00145 DNA_methylase, 1 hit
PRINTSiPR00105 C5METTRFRASE
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00675 dcm, 1 hit
PROSITEiView protein in PROSITE
PS00094 C5_MTASE_1, 1 hit
PS00095 C5_MTASE_2, 1 hit
PS51679 SAM_MT_C5, 1 hit

Sequencei

Sequence statusi: Complete.

P45000-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKCVDLFSGC GGLSLGFELA GFEICAAFEN WEKAIEIYKN NFSHPIYNID
60 70 80 90 100
LRNEKEAVEK IKKYSPDLIM GGPPCQDFSS AGKRDISLGR ADLTYSFANI
110 120 130 140 150
VCNIRPKWFV MENVEQIKKS HILQDIINQF IDFGYGLTSA ILDASYCGVP
160 170 180 190 200
QSRTRFSLIG KLNSEHNFLI PTLSRKLSDK PMTVRDYLGN SLNLEFYYRH
210 220 230 240 250
PRNYNRRGIF SIDEPSPTIR GVNRPIPKGY NINSCDPKGV ELAKVRPLTT
260 270 280 290 300
IERSYIQTFP KSFLFSGTKT DLEQMIGNAV PVNLAKFVAS AIINFEKEPI

RSMG
Length:304
Mass (Da):34,366
Last modified:November 1, 1995 - v1
Checksum:i03DA1EAB27C84BBD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA Translation: AAC22700.1
PIRiC64109
RefSeqiNP_439200.1, NC_000907.1
WP_010869113.1, NC_000907.1

Genome annotation databases

EnsemblBacteriaiAAC22700; AAC22700; HI_1041
GeneIDi950661
KEGGihin:HI1041
PATRICifig|71421.8.peg.1085

Similar proteinsi

Entry informationi

Entry nameiMTH5_HAEIN
AccessioniPrimary (citable) accession number: P45000
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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