ID   T2D5_HAEIN              Reviewed;         334 AA.
AC   P44999;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   27-MAR-2024, entry version 100.
DE   RecName: Full=Probable type II restriction enzyme HindVP {ECO:0000303|PubMed:12654995};
DE            Short=R.HindVP;
DE            EC=3.1.21.4;
DE   AltName: Full=Endonuclease HindVP;
DE   AltName: Full=Probable type-2 restriction enzyme HindVP;
GN   Name=hindVRP; OrderedLocusNames=HI_1040;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
RN   [2]
RP   NOMENCLATURE, AND SUBTYPE.
RX   PubMed=12654995; DOI=10.1093/nar/gkg274;
RA   Roberts R.J., Belfort M., Bestor T., Bhagwat A.S., Bickle T.A.,
RA   Bitinaite J., Blumenthal R.M., Degtyarev S.K., Dryden D.T., Dybvig K.,
RA   Firman K., Gromova E.S., Gumport R.I., Halford S.E., Hattman S.,
RA   Heitman J., Hornby D.P., Janulaitis A., Jeltsch A., Josephsen J., Kiss A.,
RA   Klaenhammer T.R., Kobayashi I., Kong H., Krueger D.H., Lacks S.,
RA   Marinus M.G., Miyahara M., Morgan R.D., Murray N.E., Nagaraja V.,
RA   Piekarowicz A., Pingoud A., Raleigh E., Rao D.N., Reich N., Repin V.E.,
RA   Selker E.U., Shaw P.C., Stein D.C., Stoddard B.L., Szybalski W.,
RA   Trautner T.A., Van Etten J.L., Vitor J.M., Wilson G.G., Xu S.Y.;
RT   "A nomenclature for restriction enzymes, DNA methyltransferases, homing
RT   endonucleases and their genes.";
RL   Nucleic Acids Res. 31:1805-1812(2003).
CC   -!- FUNCTION: A P subtype restriction enzyme that recognizes the double-
CC       stranded sequence 5'-GRCGYC-3'; the cleavage site is unknown.
CC       {ECO:0000303|PubMed:12654995}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage of DNA to give specific double-
CC         stranded fragments with terminal 5'-phosphates.; EC=3.1.21.4;
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DR   EMBL; L42023; AAC22699.1; -; Genomic_DNA.
DR   PIR; B64109; B64109.
DR   RefSeq; NP_439199.1; NC_000907.1.
DR   AlphaFoldDB; P44999; -.
DR   STRING; 71421.HI_1040; -.
DR   REBASE; 2819; HindVP.
DR   EnsemblBacteria; AAC22699; AAC22699; HI_1040.
DR   KEGG; hin:HI_1040; -.
DR   PATRIC; fig|71421.8.peg.1084; -.
DR   eggNOG; ENOG502Z9NT; Bacteria.
DR   HOGENOM; CLU_775334_0_0_6; -.
DR   OrthoDB; 1100091at2; -.
DR   BioCyc; HINF71421:G1GJ1-1079-MONOMER; -.
DR   PRO; PR:P44999; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0009036; F:type II site-specific deoxyribonuclease activity; IEA:UniProtKB-EC.
DR   GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR   InterPro; IPR019044; Restrct_endonuc_II_HindVP.
DR   Pfam; PF09519; RE_HindVP; 2.
PE   4: Predicted;
KW   Endonuclease; Hydrolase; Nuclease; Reference proteome; Restriction system.
FT   CHAIN           1..334
FT                   /note="Probable type II restriction enzyme HindVP"
FT                   /id="PRO_0000077322"
SQ   SEQUENCE   334 AA;  38346 MW;  8CA1F88E76E730DD CRC64;
     MLYYVPRREK SYMNIKPHLF GLNRSNRDFS LRETWGKNQF NSSFPVSLCC YMSSKGILAN
     YLSIENAEIK CSSIDIKDVF EIEPENENTF FAFETSHSIK LTALPDHTTC DLTDADFGSE
     IVIRPDSIVY LACSLAEILK ESLANCMDIP NNVDHLDWSE PKQVIPLFPH ILSTLNNLCS
     RADTIQTPFL LQPVWKTLGK SPRLADNCLD IFIWSDVAFV KFILEISNLN VNVLSINRQT
     RTAIWLYKML VDIVKYGRFN HHKIIDLCSY NTKNDKAFAS SGMITNVFMK SERLERPIIM
     KSEIKNIILG GGQELLSPER RFDAIIYNSS ELFR
//