P44997 (SERB_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoserine phosphatase
Short name=PSP
Short name=PSPase
EC=3.1.3.3

Alternative name(s):
O-phosphoserine phosphohydrolase

Gene names

Name:	serB
Ordered Locus Names:	HI_1033

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

Taxonomic identifier

71421 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	314 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	O-phospho-L(or D)-serine + H2O = L(or D)-serine + phosphate.
Cofactor	Binds 1 magnesium ion per subunit By similarity.
Pathway	Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.
Sequence similarities	Belongs to the serB family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Serine biosynthesis
Ligand	Magnesium Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	L-serine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoserine phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 314	314	Phosphoserine phosphatase		PRO_0000156888
Regions
	Region	197 – 198	2	Substrate binding By similarity
Sites
	Active site	109	1	Nucleophile By similarity
	Active site	111	1	Proton donor By similarity
	Metal binding	109	1	Magnesium By similarity
	Metal binding	111	1	Magnesium; via carbonyl oxygen By similarity
	Metal binding	265	1	Magnesium By similarity
	Binding site	118	1	Substrate By similarity
	Binding site	154	1	Substrate By similarity
	Binding site	242	1	Substrate By similarity
	Binding site	268	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P44997 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: ED565F9C78CE0FB1	FASTA	314	34,720
	10 20 30 40 50 60 MQIQCFESIT QKYPQFPTAL LANEEPIQNG EPFILYGTKL DITKLEKFQQ KCGQNFQIFD 70 80 90 100 110 120 VWMVAKNIIV LLKGQWFSDF IKFTHDVEVD IAKLDFSPKL SQAGLLVMDM DSTAIQIECI 130 140 150 160 170 180 DEIAKLAGVG ELVSAITESA MRGELDFEQS LRCRVGTLKG APESILQQVR ENLPLMSGLV 190 200 210 220 230 240 ETIQTLQKYG WKTAIASGGF TYFADYLKAL LQLDFAASNQ FDIEDGKLTG LVKGDVVDAQ 250 260 270 280 290 300 YKAKTLQHLL EEYGIDSRHS IAIGDGANDL AMMNVAGLGV AFHAKPKVQP QAQIVVNFAD 310 LTALLCLLSA NDRI

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L42023 Genomic DNA. Translation: AAC22693.1.
PIR	I64108.
RefSeq	NP_439193.1. NC_000907.1.
3D structure databases
ProteinModelPortal	P44997.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	949401.
GenomeReviews	Gene locus HI_1033 in contig L42023_GR.
KEGG	hin:HI1033.
NMPDR	fig|71421.1.peg.995.
PATRIC	20190729. VBIHaeInf48452_1077.
TIGR	HI_1033.
Phylogenomic databases
HOGENOM	HBG645339.
OMA	DYQVVRL.
ProtClustDB	PRK11133.
Enzyme and pathway databases
BioCyc	HINF71421:HI_1033-MONOMER.
Family and domain databases
InterPro	IPR005834. Dehalogen-like_hydro. IPR023214. HAD-like_dom. IPR006383. HAD-SF_hydro_IB_PSP-like. IPR023190. Pser_Pase_dom_2. IPR004469. SerB. [Graphical view]
Gene3D	G3DSA:3.40.50.1000. HAD-like_dom. 2 hits. G3DSA:1.10.150.210. Pser_Pase_dom_2. 1 hit.
KO	K01079.
Pfam	PF00702. Hydrolase. 1 hit. [Graphical view]
SUPFAM	SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR01488. HAD-SF-IB. 1 hit. TIGR00338. SerB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SERB_HAEIN

Accession

Primary (citable) accession number: P44997

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	January 25, 2012
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program