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Reviewed, UniProtKB/Swiss-Prot P44969 (IGA0_HAEIN)

Last modified June 16, 2009. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Immunoglobulin A1 protease
      Short name=IGA1 protease
    EC=3.4.21.72
Gene names
Name: iga
Synonyms: iga1
Ordered Locus Names: HI0990
OrganismHaemophilus influenzae [Complete proteome] [HAMAP]
Taxonomic identifier727 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

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Protein attributes

Sequence length1694 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Virulence factor; cleaves host immunoglobulin A producing intact Fc and Fab fragments.

Catalytic activity

Cleavage of immunoglobulin A molecules at certain Pro-|-Xaa bonds in the hinge region. No small molecule substrates are known.

Subcellular location

Secreted.

Domain

The signal peptide guides the precursor to the periplasmic space, and the C-terminal helper domain associates with the outer membrane to form a pore for excretion of the protease domain. The helper domain is then released by autoproteolysis By similarity.

Sequence similarities

Contains 1 autotransporter (TC 1.B.12) domain. [View classification]

Contains 1 peptidase S6 domain.

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Ontologies

Keywords
   Biological processVirulence
   Cellular componentMembrane
Secreted
   DomainSignal
Transmembrane
   Molecular functionHydrolase
Protease
Serine protease
   PTMZymogen
   Technical term3D-structure
Complete proteome
Gene Ontology (GO)
   Biological processpathogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

proteolysis

Inferred from electronic annotation. Source: InterPro

   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

outer membrane

Inferred from electronic annotation. Source: InterPro

   Molecular functionserine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 1014989Immunoglobulin A1 protease
PRO_0000026958
Propeptide1015 – 1694680Helper peptide Potential
PRO_0000026959

Regions

Domain1442 – 1694253Autotransporter

Sites

Active site2881 Probable

Experimental info

Sequence conflict253 – 2542EN → GV in CAB56789. Ref.1
Sequence conflict2721G → A in CAB56789. Ref.1
Sequence conflict4641G → E in CAB56789. Ref.1
Sequence conflict8661S → T in CAB56789. Ref.1
Sequence conflict10361A → D in CAB56789. Ref.1
Sequence conflict10741A → G in CAB56789. Ref.1
Sequence conflict14211A → G in CAB56789. Ref.1
Sequence conflict15451H → T in CAB56789. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
P44969-1 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: C52427013F93178C

FASTA1,694185,539
        10         20         30         40         50         60 
MLNKKFKLNF IALTVAYALT PYTEAALVRD DVDYQIFRDF AENKGRFSVG ATNVEVRDKN 

        70         80         90        100        110        120 
NHSLGNVLPN GIPMIDFSVV DVDKRIATLI NPQYVVGVKH VSNGVSELHF GNLNGNMNNG 

       130        140        150        160        170        180 
NAKSHRDVSS EENRYFSVEK NEYPTKLNGK AVTTEDQTQK RREDYYMPRL DKFVTEVAPI 

       190        200        210        220        230        240 
EASTASSDAG TYNDQNKYPA FVRLGSGSQF IYKKGDNYSL ILNNHEVGGN NLKLVGDAYT 

       250        260        270        280        290        300 
YGIAGTPYKV NHENNGLIGF GNSKEEHSDP KGILSQDPLT NYAVLGDSGS PLFVYDREKG 

       310        320        330        340        350        360 
KWLFLGSYDF WAGYNKKSWQ EWNIYKPEFA KTVLDKDTAG SLTGSNTQYN WNPTGKTSVI 

       370        380        390        400        410        420 
SNGSESLNVD LFDSSQDTDS KKNNHGKSVT LRGSGTLTLN NNIDQGAGGL FFEGDYEVKG 

       430        440        450        460        470        480 
TSDSTTWKGA GVSVADGKTV TWKVHNPKSD RLAKIGKGTL IVEGKGENKG SLKVGDGTVI 

       490        500        510        520        530        540 
LKQQADANNK VKAFSQVGIV SGRSTVVLND DKQVDPNSIY FGFRGGRLDA NGNNLTFEHI 

       550        560        570        580        590        600 
RNIDDGARLV NHNTSKTSTV TITGESLITD PNTITPYNID APDEDNPYAF RRIKDGGQLY 

       610        620        630        640        650        660 
LNLENYTYYA LRKGASTRSE LPKNSGESNE NWLYMGKTSD EAKRNVMNHI NNERMNGFNG 

       670        680        690        700        710        720 
YFGEEEGKNN GNLNVTFKGK SEQNRFLLTG GTNLNGDLKV EKGTLFLSGR PTPHARDIAG 

       730        740        750        760        770        780 
ISSTKKDQHF AENNEVVVED DWINRNFKAT NINVTNNATL YSGRNVANIT SNITASDNAK 

       790        800        810        820        830        840 
VHIGYKAGDT VCVRSDYTGY VTCTTDKLSD KALNSFNATN VSGNVNLSGN ANFVLGKANL 

       850        860        870        880        890        900 
FGTISGTGNS QVRLTENSHW HLTGDSNVNQ LNLDKGHIHL NAQNDANKVT TYNTLTVNSL 

       910        920        930        940        950        960 
SGNGSFYYLT DLSNKQGDKV VVTKSATGNF TLQVADKTGE PTKNELTLFD ASNATRNNLN 

       970        980        990       1000       1010       1020 
VSLVGNTVDL GAWKYKLRNV NGRYDLYNPE VEKRNQTVDT TNITTPNNIQ ADVPSVPSNN 

      1030       1040       1050       1060       1070       1080 
EEIARVETPV PPPAPATPSE TTETVAENSK QESKTVEKNE QDATETTAQN GEVAEEAKPS 

      1090       1100       1110       1120       1130       1140 
VKANTQTNEV AQSGSETEET QTTEIKETAK VEKEEKAKVE KDEIQEAPQM ASETSPKQAK 

      1150       1160       1170       1180       1190       1200 
PAPKEVSTDT KVEETQVQAQ PQTQSTTVAA AEATSPNSKP AEETQPSEKT NAEPVTPVVS 

      1210       1220       1230       1240       1250       1260 
KNQTENTTDQ PTEREKTAKV ETEKTQEPPQ VASQASPKQE QSETVQPQAV LESENVPTVN 

      1270       1280       1290       1300       1310       1320 
NAEEVQAQLQ TQTSATVSTK QPAPENSINT GSATAITETA EKSDKPQTET AASTEDASQH 

      1330       1340       1350       1360       1370       1380 
KANTVADNSV ANNSESSDPK SRRRRSISQP QETSAEETTA ASTDETTIAD NSKRSKPNRR 

      1390       1400       1410       1420       1430       1440 
SRRSVRSEPT VTNGSDRSTV ALRDLTSTNT NAVISDAMAK AQFVALNVGK AVSQHISQLE 

      1450       1460       1470       1480       1490       1500 
MNNEGQYNVW VSNTSMNENY SSSQYRRFSS KSTQTQLGWD QTISNNVQLG GVFTYVRNSN 

      1510       1520       1530       1540       1550       1560 
NFDKASSKNT LAQVNFYSKY YADNHWYLGI DLGYGKFQSN LKTNHNAKFA RHTAQFGLTA 

      1570       1580       1590       1600       1610       1620 
GKAFNLGNFG ITPIVGVRYS YLSNANFALA KDRIKVNPIS VKTAFAQVDL SYTYHLGEFS 

      1630       1640       1650       1660       1670       1680 
VTPILSARYD TNQGSGKINV NQYDFAYNVE NQQQYNAGLK LKYHNVKLSL IGGLTKAKQA 

      1690 
EKQKTAELKL SFSF

« Hide

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References

« Hide 'large scale' references
[1]Wright A., Fishman Y., Tai F., Plaut A.G.
Submitted (MAY-1991) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Serotype D.
[2]"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd."
Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. expand/collapse author list , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C.
Science 269:496-512(1995) [PubMed: 7542800] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
[3]"Localization of the cleavage site specificity determinant of Haemophilus influenzae immunoglobulin A1 protease genes."
Grundy F.J., Plaut A.G., Wright A.
Infect. Immun. 58:320-331(1990) [PubMed: 2105270] [Abstract]
Cited for: CHARACTERIZATION OF CLEAVAGE SITE SPECIFICITY.

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Cross-references

Sequence databases

X59800 Genomic DNA. Translation: CAB56789.1.
L42023 Genomic DNA. Translation: AAC22651.1.
PIRH64106.
RefSeqNP_439153.1.

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
3H09X-ray1.75A/B26-1006[»]
ModBaseSearch...

Genome annotation databases

GeneID950762.
GenomeReviewsGene locus HI0990 in contig L42023_GR.
KEGGhin:HI0990.
NMPDRfig|71421.1.peg.957.
TIGRHI0990.

Phylogenomic databases

HOGENOMP44969.
OMAP44969. APQDYMA.

Enzyme and pathway databases

BioCycHINF71421:HI_0990-MON.
BRENDA3.4.21.72. 109.

Family and domain databases

InterProIPR005546. Auto_transptbeta.
IPR006315. OM_autotransptr_brl.
IPR012332. P22_tailspike.
IPR000710. Peptidase_S6.
IPR004899. Pertactin.
[Graphical view]
Gene3DG3DSA:2.160.20.20. P22_tailspike. 1 hit.
PfamPF03797. Autotransporter. 1 hit.
PF02395. Peptidase_S6. 1 hit.
PF03212. Pertactin. 1 hit.
[Graphical view]
PRINTSPR00921. IGASERPTASE.
TIGRFAMsTIGR01414. autotrans_barl. 1 hit.
PROSITEPS51208. AUTOTRANSPORTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

PMAP-CutDBP44969.

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Entry information

Entry nameIGA0_HAEIN
AccessionPrimary (citable) accession number: P44969
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 16, 2009
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents