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P44961

- MENC_HAEIN

UniProt

P44961 - MENC_HAEIN

Protein

o-succinylbenzoate synthase

Gene

menC

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 2 (02 Nov 2001)
      Previous versions | rss
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    Functioni

    Converts SHCHC to OSB.By similarity

    Catalytic activityi

    (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate = 2-succinylbenzoate + H2O.

    Cofactori

    Magnesium.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei140 – 1401Proton donorBy similarity
    Metal bindingi168 – 1681MagnesiumBy similarity
    Metal bindingi197 – 1971MagnesiumBy similarity
    Metal bindingi220 – 2201MagnesiumBy similarity
    Active sitei242 – 2421Proton acceptorBy similarity

    GO - Molecular functioni

    1. hydro-lyase activity Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: InterPro

    GO - Biological processi

    1. menaquinone biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Menaquinone biosynthesis

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00079; UER00165.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    o-succinylbenzoate synthase (EC:4.2.1.113)
    Short name:
    OSB synthase
    Short name:
    OSBS
    Alternative name(s):
    4-(2'-carboxyphenyl)-4-oxybutyric acid synthase
    o-succinylbenzoic acid synthase
    Gene namesi
    Name:menC
    Ordered Locus Names:HI_0969
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 329329o-succinylbenzoate synthasePRO_0000171272Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi71421.HI0969.

    Structurei

    3D structure databases

    ProteinModelPortaliP44961.
    SMRiP44961. Positions 4-322.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1441.
    KOiK02549.
    OMAiYEANRDG.
    OrthoDBiEOG6VXFBR.

    Family and domain databases

    Gene3Di3.20.20.120. 1 hit.
    3.30.390.10. 1 hit.
    HAMAPiMF_00470. MenC_1.
    InterProiIPR029065. Enolase_C-like.
    IPR029017. Enolase_N_like.
    IPR013342. Mandelate_racemase_C.
    IPR001354. MR_MLE.
    IPR010196. OSB_synthase.
    [Graphical view]
    PANTHERiPTHR13794. PTHR13794. 1 hit.
    PfamiPF01188. MR_MLE. 1 hit.
    [Graphical view]
    SMARTiSM00922. MR_MLE. 1 hit.
    [Graphical view]
    SUPFAMiSSF51604. SSF51604. 1 hit.
    SSF54826. SSF54826. 1 hit.
    TIGRFAMsiTIGR01927. menC_gamma/gm+. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P44961-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEKSFNLYR YSIPVDSQLI LRDRFLKRRE GLIVRVSCSR DGWGEIAPLP    50
    GFSEETLDQA QEQAIEWLTT WCNASCDAPR VPLDGTYPSV AFGISCAMDE 100
    MKGYLQAEGN YHTAPLCYGD PDELYAKLAS MEGEKVAKMK VGIYEANRDG 150
    LIADMFLEAI PDLQLRLDAN RHWSLEKALQ FAAKVKLQHR KRIQFLEEPC 200
    KTQALSREFA VQTDIAIAWD ESVREPNFCL EKEPHLSAVV IKPTLIGSIQ 250
    RCTELINQAH SLGLKAVISS SIESSLGLSQ LARIAQQYTP NVTPGLDTLD 300
    LMEYQVLRAW PSSDLPIVDL ESEFITKII 329
    Length:329
    Mass (Da):36,970
    Last modified:November 2, 2001 - v2
    Checksum:i26353A1B50D5FF60
    GO

    Sequence cautioni

    The sequence AAC22626.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22626.1. Different initiation.
    PIRiC64105.
    RefSeqiNP_439130.2. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC22626; AAC22626; HI_0969.
    GeneIDi949968.
    KEGGihin:HI0969.
    PATRICi20190595. VBIHaeInf48452_1010.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22626.1 . Different initiation.
    PIRi C64105.
    RefSeqi NP_439130.2. NC_000907.1.

    3D structure databases

    ProteinModelPortali P44961.
    SMRi P44961. Positions 4-322.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI0969.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC22626 ; AAC22626 ; HI_0969 .
    GeneIDi 949968.
    KEGGi hin:HI0969.
    PATRICi 20190595. VBIHaeInf48452_1010.

    Phylogenomic databases

    eggNOGi COG1441.
    KOi K02549.
    OMAi YEANRDG.
    OrthoDBi EOG6VXFBR.

    Enzyme and pathway databases

    UniPathwayi UPA00079 ; UER00165 .

    Family and domain databases

    Gene3Di 3.20.20.120. 1 hit.
    3.30.390.10. 1 hit.
    HAMAPi MF_00470. MenC_1.
    InterProi IPR029065. Enolase_C-like.
    IPR029017. Enolase_N_like.
    IPR013342. Mandelate_racemase_C.
    IPR001354. MR_MLE.
    IPR010196. OSB_synthase.
    [Graphical view ]
    PANTHERi PTHR13794. PTHR13794. 1 hit.
    Pfami PF01188. MR_MLE. 1 hit.
    [Graphical view ]
    SMARTi SM00922. MR_MLE. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51604. SSF51604. 1 hit.
    SSF54826. SSF54826. 1 hit.
    TIGRFAMsi TIGR01927. menC_gamma/gm+. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiMENC_HAEIN
    AccessioniPrimary (citable) accession number: P44961
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 2, 2001
    Last modified: October 1, 2014
    This is version 94 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3