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P44961 (MENC_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
o-succinylbenzoate synthase

Short name=OSB synthase
Short name=OSBS
EC=4.2.1.113
Alternative name(s):
4-(2'-carboxyphenyl)-4-oxybutyric acid synthase
o-succinylbenzoic acid synthase
Gene names
Name:menC
Ordered Locus Names:HI_0969
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length329 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts SHCHC to OSB By similarity. HAMAP-Rule MF_00470

Catalytic activity

(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate = 2-succinylbenzoate + H2O. HAMAP-Rule MF_00470

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00470

Pathway

Cofactor biosynthesis; menaquinone biosynthesis; menaquinone-2 from chorismate: step 4/8. HAMAP-Rule MF_00470

Sequence similarities

Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.

Sequence caution

The sequence AAC22626.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processMenaquinone biosynthesis
   LigandMagnesium
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmenaquinone biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionhydro-lyase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

magnesium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 329329o-succinylbenzoate synthase HAMAP-Rule MF_00470
PRO_0000171272

Sites

Active site1401Proton donor By similarity
Active site2421Proton acceptor By similarity
Metal binding1681Magnesium By similarity
Metal binding1971Magnesium By similarity
Metal binding2201Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
P44961 [UniParc].

Last modified November 2, 2001. Version 2.
Checksum: 26353A1B50D5FF60

FASTA32936,970
        10         20         30         40         50         60 
MAEKSFNLYR YSIPVDSQLI LRDRFLKRRE GLIVRVSCSR DGWGEIAPLP GFSEETLDQA 

        70         80         90        100        110        120 
QEQAIEWLTT WCNASCDAPR VPLDGTYPSV AFGISCAMDE MKGYLQAEGN YHTAPLCYGD 

       130        140        150        160        170        180 
PDELYAKLAS MEGEKVAKMK VGIYEANRDG LIADMFLEAI PDLQLRLDAN RHWSLEKALQ 

       190        200        210        220        230        240 
FAAKVKLQHR KRIQFLEEPC KTQALSREFA VQTDIAIAWD ESVREPNFCL EKEPHLSAVV 

       250        260        270        280        290        300 
IKPTLIGSIQ RCTELINQAH SLGLKAVISS SIESSLGLSQ LARIAQQYTP NVTPGLDTLD 

       310        320 
LMEYQVLRAW PSSDLPIVDL ESEFITKII 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC22626.1. Different initiation.
PIRC64105.
RefSeqNP_439130.2. NC_000907.1.

3D structure databases

ProteinModelPortalP44961.
SMRP44961. Positions 4-322.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI0969.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC22626; AAC22626; HI_0969.
GeneID949968.
KEGGhin:HI0969.
PATRIC20190595. VBIHaeInf48452_1010.

Phylogenomic databases

eggNOGCOG1441.
KOK02549.
OMAYEANRDG.
OrthoDBEOG6VXFBR.
ProtClustDBPRK05105.

Enzyme and pathway databases

UniPathwayUPA00079; UER00165.

Family and domain databases

HAMAPMF_00470. MenC_1.
InterProIPR013342. Mandelate_racemase_C.
IPR010196. OSB_synthase.
[Graphical view]
PfamPF01188. MR_MLE. 1 hit.
[Graphical view]
SMARTSM00922. MR_MLE. 1 hit.
[Graphical view]
TIGRFAMsTIGR01927. menC_gamma/gm+. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMENC_HAEIN
AccessionPrimary (citable) accession number: P44961
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 2, 2001
Last modified: February 19, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names