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Protein

o-succinylbenzoate synthase

Gene

menC

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).UniRule annotation

Catalytic activityi

(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate = 2-succinylbenzoate + H2O.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei140 – 1401Proton donorUniRule annotation
Metal bindingi168 – 1681MagnesiumUniRule annotation
Metal bindingi197 – 1971MagnesiumUniRule annotation
Metal bindingi220 – 2201MagnesiumUniRule annotation
Active sitei242 – 2421Proton acceptorUniRule annotation

GO - Molecular functioni

  1. hydro-lyase activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. menaquinone biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Menaquinone biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00079.
UPA01057; UER00165.

Names & Taxonomyi

Protein namesi
Recommended name:
o-succinylbenzoate synthaseUniRule annotation (EC:4.2.1.113UniRule annotation)
Short name:
OSB synthaseUniRule annotation
Short name:
OSBSUniRule annotation
Alternative name(s):
4-(2'-carboxyphenyl)-4-oxybutyric acid synthaseUniRule annotation
o-succinylbenzoic acid synthaseUniRule annotation
Gene namesi
Name:menCUniRule annotation
Ordered Locus Names:HI_0969
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 329329o-succinylbenzoate synthasePRO_0000171272Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0969.

Structurei

3D structure databases

ProteinModelPortaliP44961.
SMRiP44961. Positions 4-322.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1441.
KOiK02549.
OMAiEEPCKTP.
OrthoDBiEOG6VXFBR.

Family and domain databases

Gene3Di3.20.20.120. 1 hit.
3.30.390.10. 1 hit.
HAMAPiMF_00470. MenC_1.
InterProiIPR029065. Enolase_C-like.
IPR029017. Enolase_N_like.
IPR013342. Mandelate_racemase_C.
IPR001354. MR/MLE/MAL.
IPR010196. OSB_synthase.
[Graphical view]
PANTHERiPTHR13794. PTHR13794. 1 hit.
PfamiPF01188. MR_MLE. 1 hit.
[Graphical view]
SMARTiSM00922. MR_MLE. 1 hit.
[Graphical view]
SUPFAMiSSF51604. SSF51604. 1 hit.
SSF54826. SSF54826. 1 hit.
TIGRFAMsiTIGR01927. menC_gamma/gm+. 1 hit.

Sequencei

Sequence statusi: Complete.

P44961-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEKSFNLYR YSIPVDSQLI LRDRFLKRRE GLIVRVSCSR DGWGEIAPLP
60 70 80 90 100
GFSEETLDQA QEQAIEWLTT WCNASCDAPR VPLDGTYPSV AFGISCAMDE
110 120 130 140 150
MKGYLQAEGN YHTAPLCYGD PDELYAKLAS MEGEKVAKMK VGIYEANRDG
160 170 180 190 200
LIADMFLEAI PDLQLRLDAN RHWSLEKALQ FAAKVKLQHR KRIQFLEEPC
210 220 230 240 250
KTQALSREFA VQTDIAIAWD ESVREPNFCL EKEPHLSAVV IKPTLIGSIQ
260 270 280 290 300
RCTELINQAH SLGLKAVISS SIESSLGLSQ LARIAQQYTP NVTPGLDTLD
310 320
LMEYQVLRAW PSSDLPIVDL ESEFITKII
Length:329
Mass (Da):36,970
Last modified:November 2, 2001 - v2
Checksum:i26353A1B50D5FF60
GO

Sequence cautioni

The sequence AAC22626.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22626.1. Different initiation.
PIRiC64105.
RefSeqiNP_439130.2. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22626; AAC22626; HI_0969.
GeneIDi949968.
KEGGihin:HI0969.
PATRICi20190595. VBIHaeInf48452_1010.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22626.1. Different initiation.
PIRiC64105.
RefSeqiNP_439130.2. NC_000907.1.

3D structure databases

ProteinModelPortaliP44961.
SMRiP44961. Positions 4-322.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI0969.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC22626; AAC22626; HI_0969.
GeneIDi949968.
KEGGihin:HI0969.
PATRICi20190595. VBIHaeInf48452_1010.

Phylogenomic databases

eggNOGiCOG1441.
KOiK02549.
OMAiEEPCKTP.
OrthoDBiEOG6VXFBR.

Enzyme and pathway databases

UniPathwayiUPA00079.
UPA01057; UER00165.

Family and domain databases

Gene3Di3.20.20.120. 1 hit.
3.30.390.10. 1 hit.
HAMAPiMF_00470. MenC_1.
InterProiIPR029065. Enolase_C-like.
IPR029017. Enolase_N_like.
IPR013342. Mandelate_racemase_C.
IPR001354. MR/MLE/MAL.
IPR010196. OSB_synthase.
[Graphical view]
PANTHERiPTHR13794. PTHR13794. 1 hit.
PfamiPF01188. MR_MLE. 1 hit.
[Graphical view]
SMARTiSM00922. MR_MLE. 1 hit.
[Graphical view]
SUPFAMiSSF51604. SSF51604. 1 hit.
SSF54826. SSF54826. 1 hit.
TIGRFAMsiTIGR01927. menC_gamma/gm+. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiMENC_HAEIN
AccessioniPrimary (citable) accession number: P44961
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 2, 2001
Last modified: February 4, 2015
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.