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P44961

- MENC_HAEIN

UniProt

P44961 - MENC_HAEIN

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Protein
o-succinylbenzoate synthase
Gene
menC, HI_0969
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Converts SHCHC to OSB By similarity.UniRule annotation

Catalytic activityi

(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate = 2-succinylbenzoate + H2O.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei140 – 1401Proton donor By similarity
Metal bindingi168 – 1681Magnesium By similarity
Metal bindingi197 – 1971Magnesium By similarity
Metal bindingi220 – 2201Magnesium By similarity
Active sitei242 – 2421Proton acceptor By similarity

GO - Molecular functioni

  1. hydro-lyase activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: InterPro

GO - Biological processi

  1. menaquinone biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Menaquinone biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00079; UER00165.

Names & Taxonomyi

Protein namesi
Recommended name:
o-succinylbenzoate synthase (EC:4.2.1.113)
Short name:
OSB synthase
Short name:
OSBS
Alternative name(s):
4-(2'-carboxyphenyl)-4-oxybutyric acid synthase
o-succinylbenzoic acid synthase
Gene namesi
Name:menC
Ordered Locus Names:HI_0969
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 329329o-succinylbenzoate synthaseUniRule annotation
PRO_0000171272Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0969.

Structurei

3D structure databases

ProteinModelPortaliP44961.
SMRiP44961. Positions 4-322.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1441.
KOiK02549.
OMAiYEANRDG.
OrthoDBiEOG6VXFBR.

Family and domain databases

Gene3Di3.20.20.120. 1 hit.
3.30.390.10. 1 hit.
HAMAPiMF_00470. MenC_1.
InterProiIPR029065. Enolase_C-like.
IPR029017. Enolase_N_like.
IPR013342. Mandelate_racemase_C.
IPR001354. MR_MLE.
IPR010196. OSB_synthase.
[Graphical view]
PANTHERiPTHR13794. PTHR13794. 1 hit.
PfamiPF01188. MR_MLE. 1 hit.
[Graphical view]
SMARTiSM00922. MR_MLE. 1 hit.
[Graphical view]
SUPFAMiSSF51604. SSF51604. 1 hit.
SSF54826. SSF54826. 1 hit.
TIGRFAMsiTIGR01927. menC_gamma/gm+. 1 hit.

Sequencei

Sequence statusi: Complete.

P44961-1 [UniParc]FASTAAdd to Basket

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MAEKSFNLYR YSIPVDSQLI LRDRFLKRRE GLIVRVSCSR DGWGEIAPLP    50
GFSEETLDQA QEQAIEWLTT WCNASCDAPR VPLDGTYPSV AFGISCAMDE 100
MKGYLQAEGN YHTAPLCYGD PDELYAKLAS MEGEKVAKMK VGIYEANRDG 150
LIADMFLEAI PDLQLRLDAN RHWSLEKALQ FAAKVKLQHR KRIQFLEEPC 200
KTQALSREFA VQTDIAIAWD ESVREPNFCL EKEPHLSAVV IKPTLIGSIQ 250
RCTELINQAH SLGLKAVISS SIESSLGLSQ LARIAQQYTP NVTPGLDTLD 300
LMEYQVLRAW PSSDLPIVDL ESEFITKII 329
Length:329
Mass (Da):36,970
Last modified:November 2, 2001 - v2
Checksum:i26353A1B50D5FF60
GO

Sequence cautioni

The sequence AAC22626.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22626.1. Different initiation.
PIRiC64105.
RefSeqiNP_439130.2. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22626; AAC22626; HI_0969.
GeneIDi949968.
KEGGihin:HI0969.
PATRICi20190595. VBIHaeInf48452_1010.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22626.1 . Different initiation.
PIRi C64105.
RefSeqi NP_439130.2. NC_000907.1.

3D structure databases

ProteinModelPortali P44961.
SMRi P44961. Positions 4-322.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0969.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC22626 ; AAC22626 ; HI_0969 .
GeneIDi 949968.
KEGGi hin:HI0969.
PATRICi 20190595. VBIHaeInf48452_1010.

Phylogenomic databases

eggNOGi COG1441.
KOi K02549.
OMAi YEANRDG.
OrthoDBi EOG6VXFBR.

Enzyme and pathway databases

UniPathwayi UPA00079 ; UER00165 .

Family and domain databases

Gene3Di 3.20.20.120. 1 hit.
3.30.390.10. 1 hit.
HAMAPi MF_00470. MenC_1.
InterProi IPR029065. Enolase_C-like.
IPR029017. Enolase_N_like.
IPR013342. Mandelate_racemase_C.
IPR001354. MR_MLE.
IPR010196. OSB_synthase.
[Graphical view ]
PANTHERi PTHR13794. PTHR13794. 1 hit.
Pfami PF01188. MR_MLE. 1 hit.
[Graphical view ]
SMARTi SM00922. MR_MLE. 1 hit.
[Graphical view ]
SUPFAMi SSF51604. SSF51604. 1 hit.
SSF54826. SSF54826. 1 hit.
TIGRFAMsi TIGR01927. menC_gamma/gm+. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiMENC_HAEIN
AccessioniPrimary (citable) accession number: P44961
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 2, 2001
Last modified: June 11, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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