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P44956 (Y961_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
HIT-like protein HI_0961

EC=3.-.-.-
Alternative name(s):
Purine nucleoside phosphoramidase
Gene names
Ordered Locus Names:HI_0961
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length116 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Hydrolyzes purine nucleotide phosphoramidates, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate), guanosine 5'monophosphomorpholidate (GMP-morpholidate) and tryptamine 5'guanosine monophosphate (TpGd). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase and lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) By similarity.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the HINT family.

Contains 1 HIT domain.

Sequence caution

The sequence AAC22621.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   LigandNucleotide-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionhydrolase activity

Inferred from electronic annotation. Source: UniProtKB-KW

nucleotide binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 116116HIT-like protein HI_0961
PRO_0000109833

Regions

Domain6 – 115110HIT
Nucleotide binding30 – 323Purine nucleotide phosphoramidate By similarity
Nucleotide binding96 – 972Purine nucleotide phosphoramidate By similarity
Nucleotide binding101 – 1033Purine nucleotide phosphoramidate By similarity
Motif99 – 1035Histidine triad motif

Sites

Active site1011Tele-AMP-histidine intermediate By similarity
Binding site881Purine nucleotide phosphoramidate By similarity

Sequences

Sequence LengthMass (Da)Tools
P44956 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 904B9A3211757F12

FASTA11612,887
        10         20         30         40         50         60 
MAEETIFSKI IRKEIPANIV YQDELVTAFR DISPQAKTHI LIIPNKVIPT VNDVTEQDEV 

        70         80         90        100        110 
ALGRLFSVAA KLAKEEGVAE DGYRLIVNCN KHGGQEVFHL HMHLVGGEPL GRMLAK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC22621.1. Different initiation.
PIRG64162.
RefSeqNP_439122.2. NC_000907.1.

3D structure databases

ProteinModelPortalP44956.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI0961.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC22621; AAC22621; HI_0961.
GeneID950594.
KEGGhin:HI0961.
PATRIC20190581. VBIHaeInf48452_1003.

Phylogenomic databases

eggNOGCOG0537.
KOK02503.
OMADRELVGH.
OrthoDBEOG69GZSV.
PhylomeDBP44956.

Family and domain databases

Gene3D3.30.428.10. 1 hit.
InterProIPR019808. Histidine_triad_CS.
IPR001310. Histidine_triad_HIT.
IPR011146. HIT-like.
[Graphical view]
PANTHERPTHR23089. PTHR23089. 1 hit.
PfamPF01230. HIT. 1 hit.
[Graphical view]
PRINTSPR00332. HISTRIAD.
SUPFAMSSF54197. SSF54197. 1 hit.
PROSITEPS00892. HIT_1. 1 hit.
PS51084. HIT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameY961_HAEIN
AccessionPrimary (citable) accession number: P44956
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names