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P44956

- Y961_HAEIN

UniProt

P44956 - Y961_HAEIN

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Protein
HIT-like protein HI_0961
Gene
HI_0961
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Hydrolyzes purine nucleotide phosphoramidates, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate), guanosine 5'monophosphomorpholidate (GMP-morpholidate) and tryptamine 5'guanosine monophosphate (TpGd). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase and lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei88 – 881Purine nucleotide phosphoramidate By similarity
Active sitei101 – 1011Tele-AMP-histidine intermediate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi30 – 323Purine nucleotide phosphoramidate By similarity
Nucleotide bindingi96 – 972Purine nucleotide phosphoramidate By similarity
Nucleotide bindingi101 – 1033Purine nucleotide phosphoramidate By similarity

GO - Molecular functioni

  1. hydrolase activity Source: UniProtKB-KW
  2. nucleotide binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HIT-like protein HI_0961 (EC:3.-.-.-)
Alternative name(s):
Purine nucleoside phosphoramidase
Gene namesi
Ordered Locus Names:HI_0961
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 116116HIT-like protein HI_0961
PRO_0000109833Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi71421.HI0961.

Structurei

3D structure databases

ProteinModelPortaliP44956.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 115110HIT
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi99 – 1035Histidine triad motif

Sequence similaritiesi

Belongs to the HINT family.
Contains 1 HIT domain.

Phylogenomic databases

eggNOGiCOG0537.
KOiK02503.
OMAiDRELVGH.
OrthoDBiEOG69GZSV.
PhylomeDBiP44956.

Family and domain databases

Gene3Di3.30.428.10. 1 hit.
InterProiIPR019808. Histidine_triad_CS.
IPR001310. Histidine_triad_HIT.
IPR011146. HIT-like.
[Graphical view]
PANTHERiPTHR23089. PTHR23089. 1 hit.
PfamiPF01230. HIT. 1 hit.
[Graphical view]
PRINTSiPR00332. HISTRIAD.
SUPFAMiSSF54197. SSF54197. 1 hit.
PROSITEiPS00892. HIT_1. 1 hit.
PS51084. HIT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P44956-1 [UniParc]FASTAAdd to Basket

« Hide

MAEETIFSKI IRKEIPANIV YQDELVTAFR DISPQAKTHI LIIPNKVIPT    50
VNDVTEQDEV ALGRLFSVAA KLAKEEGVAE DGYRLIVNCN KHGGQEVFHL 100
HMHLVGGEPL GRMLAK 116
Length:116
Mass (Da):12,887
Last modified:November 1, 1995 - v1
Checksum:i904B9A3211757F12
GO

Sequence cautioni

The sequence AAC22621.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22621.1. Different initiation.
PIRiG64162.
RefSeqiNP_439122.2. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22621; AAC22621; HI_0961.
GeneIDi950594.
KEGGihin:HI0961.
PATRICi20190581. VBIHaeInf48452_1003.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22621.1 . Different initiation.
PIRi G64162.
RefSeqi NP_439122.2. NC_000907.1.

3D structure databases

ProteinModelPortali P44956.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0961.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC22621 ; AAC22621 ; HI_0961 .
GeneIDi 950594.
KEGGi hin:HI0961.
PATRICi 20190581. VBIHaeInf48452_1003.

Phylogenomic databases

eggNOGi COG0537.
KOi K02503.
OMAi DRELVGH.
OrthoDBi EOG69GZSV.
PhylomeDBi P44956.

Family and domain databases

Gene3Di 3.30.428.10. 1 hit.
InterProi IPR019808. Histidine_triad_CS.
IPR001310. Histidine_triad_HIT.
IPR011146. HIT-like.
[Graphical view ]
PANTHERi PTHR23089. PTHR23089. 1 hit.
Pfami PF01230. HIT. 1 hit.
[Graphical view ]
PRINTSi PR00332. HISTRIAD.
SUPFAMi SSF54197. SSF54197. 1 hit.
PROSITEi PS00892. HIT_1. 1 hit.
PS51084. HIT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
  2. "Two-dimensional map of the proteome of Haemophilus influenzae."
    Langen H., Takacs B., Evers S., Berndt P., Lahm H.W., Wipf B., Gray C., Fountoulakis M.
    Electrophoresis 21:411-429(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiY961_HAEIN
AccessioniPrimary (citable) accession number: P44956
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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