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P44956

- Y961_HAEIN

UniProt

P44956 - Y961_HAEIN

Protein

HIT-like protein HI_0961

Gene

HI_0961

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Hydrolyzes purine nucleotide phosphoramidates, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate), guanosine 5'monophosphomorpholidate (GMP-morpholidate) and tryptamine 5'guanosine monophosphate (TpGd). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase and lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei88 – 881Purine nucleotide phosphoramidateBy similarity
    Active sitei101 – 1011Tele-AMP-histidine intermediateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi30 – 323Purine nucleotide phosphoramidateBy similarity
    Nucleotide bindingi96 – 972Purine nucleotide phosphoramidateBy similarity
    Nucleotide bindingi101 – 1033Purine nucleotide phosphoramidateBy similarity

    GO - Molecular functioni

    1. hydrolase activity Source: UniProtKB-KW
    2. nucleotide binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    HIT-like protein HI_0961 (EC:3.-.-.-)
    Alternative name(s):
    Purine nucleoside phosphoramidase
    Gene namesi
    Ordered Locus Names:HI_0961
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 116116HIT-like protein HI_0961PRO_0000109833Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi71421.HI0961.

    Structurei

    3D structure databases

    ProteinModelPortaliP44956.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini6 – 115110HITPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi99 – 1035Histidine triad motif

    Sequence similaritiesi

    Belongs to the HINT family.Curated
    Contains 1 HIT domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0537.
    KOiK02503.
    OMAiDRELVGH.
    OrthoDBiEOG69GZSV.
    PhylomeDBiP44956.

    Family and domain databases

    Gene3Di3.30.428.10. 1 hit.
    InterProiIPR019808. Histidine_triad_CS.
    IPR001310. Histidine_triad_HIT.
    IPR011146. HIT-like.
    [Graphical view]
    PANTHERiPTHR23089. PTHR23089. 1 hit.
    PfamiPF01230. HIT. 1 hit.
    [Graphical view]
    PRINTSiPR00332. HISTRIAD.
    SUPFAMiSSF54197. SSF54197. 1 hit.
    PROSITEiPS00892. HIT_1. 1 hit.
    PS51084. HIT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P44956-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEETIFSKI IRKEIPANIV YQDELVTAFR DISPQAKTHI LIIPNKVIPT    50
    VNDVTEQDEV ALGRLFSVAA KLAKEEGVAE DGYRLIVNCN KHGGQEVFHL 100
    HMHLVGGEPL GRMLAK 116
    Length:116
    Mass (Da):12,887
    Last modified:November 1, 1995 - v1
    Checksum:i904B9A3211757F12
    GO

    Sequence cautioni

    The sequence AAC22621.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22621.1. Different initiation.
    PIRiG64162.
    RefSeqiNP_439122.2. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC22621; AAC22621; HI_0961.
    GeneIDi950594.
    KEGGihin:HI0961.
    PATRICi20190581. VBIHaeInf48452_1003.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22621.1 . Different initiation.
    PIRi G64162.
    RefSeqi NP_439122.2. NC_000907.1.

    3D structure databases

    ProteinModelPortali P44956.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI0961.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC22621 ; AAC22621 ; HI_0961 .
    GeneIDi 950594.
    KEGGi hin:HI0961.
    PATRICi 20190581. VBIHaeInf48452_1003.

    Phylogenomic databases

    eggNOGi COG0537.
    KOi K02503.
    OMAi DRELVGH.
    OrthoDBi EOG69GZSV.
    PhylomeDBi P44956.

    Family and domain databases

    Gene3Di 3.30.428.10. 1 hit.
    InterProi IPR019808. Histidine_triad_CS.
    IPR001310. Histidine_triad_HIT.
    IPR011146. HIT-like.
    [Graphical view ]
    PANTHERi PTHR23089. PTHR23089. 1 hit.
    Pfami PF01230. HIT. 1 hit.
    [Graphical view ]
    PRINTSi PR00332. HISTRIAD.
    SUPFAMi SSF54197. SSF54197. 1 hit.
    PROSITEi PS00892. HIT_1. 1 hit.
    PS51084. HIT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
    2. "Two-dimensional map of the proteome of Haemophilus influenzae."
      Langen H., Takacs B., Evers S., Berndt P., Lahm H.W., Wipf B., Gray C., Fountoulakis M.
      Electrophoresis 21:411-429(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiY961_HAEIN
    AccessioniPrimary (citable) accession number: P44956
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3