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P44955

- NAGZ_HAEIN

UniProt

P44955 - NAGZ_HAEIN

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Protein

Beta-hexosaminidase

Gene
nagZ, HI_0959
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides By similarity.UniRule annotation

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei62 – 621Substrate By similarity
Binding sitei70 – 701Substrate By similarity
Binding sitei133 – 1331Substrate By similarity
Sitei174 – 1741Important for catalytic activity By similarity
Active sitei176 – 1761Proton donor/acceptor By similarity
Active sitei248 – 2481Nucleophile By similarity

GO - Molecular functioni

  1. beta-N-acetylhexosaminidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. cell cycle Source: UniProtKB-KW
  3. cell division Source: UniProtKB-KW
  4. peptidoglycan biosynthetic process Source: UniProtKB-KW
  5. peptidoglycan turnover Source: UniProtKB-HAMAP
  6. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00544.

Protein family/group databases

CAZyiGH3. Glycoside Hydrolase Family 3.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-hexosaminidase (EC:3.2.1.52)
Alternative name(s):
Beta-N-acetylhexosaminidase
N-acetyl-beta-glucosaminidase
Gene namesi
Name:nagZ
Ordered Locus Names:HI_0959
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 351351Beta-hexosaminidaseUniRule annotationPRO_0000210789Add
BLAST

Interactioni

Subunit structurei

Monomer Reviewed prediction.

Protein-protein interaction databases

STRINGi71421.HI0959.

Structurei

3D structure databases

ProteinModelPortaliP44955.
SMRiP44955. Positions 1-298.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni163 – 1642Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1472.
KOiK01207.
OMAiADSHIAM.
OrthoDBiEOG6BCT06.
PhylomeDBiP44955.

Family and domain databases

Gene3Di3.20.20.300. 1 hit.
HAMAPiMF_00364. NagZ.
InterProiIPR022956. Beta_hexosaminidase_bac.
IPR019800. Glyco_hydro_3_AS.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00933. Glyco_hydro_3. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00775. GLYCOSYL_HYDROL_F3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P44955-1 [UniParc]FASTAAdd to Basket

« Hide

MSSLLIDLKG KELEQEEVEL LSHPLVAGLI LFTRNFENRE QIQELIRSVR    50
QRVKKPLLIT VDQEGGRVQR FRDGFTMLPS MQAFQETLSA TEQVSFAKEA 100
GWQMAAEMIA LDIDLSFAPV LDLGHECRAI GDRSFSSDVK SAVNLATAFI 150
DGMHQAGMAS TGKHFPGHGH VLADSHLETP YDDRTKEEIF SGDLQPFQQL 200
ISQNKLDAIM PAHVIYSQCD SQPASGSKYW LKEILRKKLN FQGTIFSDDL 250
GMKGAGVMGN FVERSKKALN AGCDLLLLCN EREGVIQVLD NLKLTENQPH 300
FMARQARLQS LFKRRVINWN DLISDQRWRL NYQKLADIQS RWLDIQAAKN 350
D 351
Length:351
Mass (Da):39,704
Last modified:November 1, 1995 - v1
Checksum:iD33A955A65DEDA05
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22620.1.
PIRiF64162.
RefSeqiNP_439120.1. NC_000907.1.
WP_005693307.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22620; AAC22620; HI_0959.
GeneIDi949658.
KEGGihin:HI0959.
PATRICi20190577. VBIHaeInf48452_1001.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22620.1 .
PIRi F64162.
RefSeqi NP_439120.1. NC_000907.1.
WP_005693307.1. NC_000907.1.

3D structure databases

ProteinModelPortali P44955.
SMRi P44955. Positions 1-298.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0959.

Protein family/group databases

CAZyi GH3. Glycoside Hydrolase Family 3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC22620 ; AAC22620 ; HI_0959 .
GeneIDi 949658.
KEGGi hin:HI0959.
PATRICi 20190577. VBIHaeInf48452_1001.

Phylogenomic databases

eggNOGi COG1472.
KOi K01207.
OMAi ADSHIAM.
OrthoDBi EOG6BCT06.
PhylomeDBi P44955.

Enzyme and pathway databases

UniPathwayi UPA00544 .

Family and domain databases

Gene3Di 3.20.20.300. 1 hit.
HAMAPi MF_00364. NagZ.
InterProi IPR022956. Beta_hexosaminidase_bac.
IPR019800. Glyco_hydro_3_AS.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF00933. Glyco_hydro_3. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
PROSITEi PS00775. GLYCOSYL_HYDROL_F3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiNAGZ_HAEIN
AccessioniPrimary (citable) accession number: P44955
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 3, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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