Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

RecBCD enzyme subunit RecC

Gene

recC

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild-type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity.UniRule annotation

Catalytic activityi

Exonucleolytic cleavage (in the presence of ATP) in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Helicase, Hydrolase, Nuclease

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RecBCD enzyme subunit RecCUniRule annotation (EC:3.1.11.5UniRule annotation)
Alternative name(s):
Exonuclease V subunit RecCUniRule annotation
Short name:
ExoV subunit RecCUniRule annotation
Helicase/nuclease RecBCD subunit RecCUniRule annotation
Gene namesi
Name:recCUniRule annotation
Ordered Locus Names:HI_0942
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11211121RecBCD enzyme subunit RecCPRO_0000087121Add
BLAST

Interactioni

Subunit structurei

Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding.UniRule annotation

Protein-protein interaction databases

STRINGi71421.HI0942.

Structurei

3D structure databases

ProteinModelPortaliP44945.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RecC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DSY. Bacteria.
COG1330. LUCA.
KOiK03583.
OMAiSWMRRYP.
OrthoDBiEOG61P6M4.
PhylomeDBiP44945.

Family and domain databases

Gene3Di1.10.10.160. 1 hit.
3.40.50.300. 2 hits.
HAMAPiMF_01486. RecC.
InterProiIPR013986. DExx_box_DNA_helicase_dom.
IPR027417. P-loop_NTPase.
IPR006697. RecC.
IPR011335. Restrct_endonuc-II-like.
[Graphical view]
PIRSFiPIRSF000980. RecC. 1 hit.
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF52980. SSF52980. 1 hit.
TIGRFAMsiTIGR01450. recC. 1 hit.

Sequencei

Sequence statusi: Complete.

P44945-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFIVYYSNQL EKQKEILSSL FKSLPPEDPF QQDIILVQSP NMAQWLQIEL
60 70 80 90 100
AKETGISANL KFPMPASFIW QLYAQNLPAT ALENPFDKDS MMWRLMRLIP
110 120 130 140 150
IFLEKENFSP LRNYLSSSPH SEQYKLYQLS SKIADLFDQY LVYRPEWIFA
160 170 180 190 200
WEKGEDEQIT DQIQKQQPNL NATLFAQIQG NTKWQGELWR ALVVDVKSDV
210 220 230 240 250
NEATHRAALH NQFLALLADK KAPKKLPSRI FIFGIPALPT AYLNILQAIS
260 270 280 290 300
SEVDIHLFFN NPCQEYWGDI SDLRLDYLRS RQRYQFNKQD ENQPLFSEDQ
310 320 330 340 350
LSQLENAQFD VTYQKENLQL GNPLLAAWGK MGRDFLYILV RDEEHIPTYP
360 370 380 390 400
VNAYQEIESN SLLGQLQSQI LHLENKPLNI AKNDRTLTLH SCHSAMREVE
410 420 430 440 450
VLHDYLLDLF NQDPSLTPKD VVVMVADINQ YTPYIQAVFG QKNGDVPQIP
460 470 480 490 500
FSLSDNKLSE SDVLVSSYLT LLRLKESNFS AEDVLVLLDI PAMRERFNIS
510 520 530 540 550
LADLPLVREW VTDSGIRFGL QKNQDGINFN SWQAGLERMI LGYAMREEQG
560 570 580 590 600
IWQDSLGLNS SYGLKGELAG NLSHFFTALS ALHETLQQAH SIEKWQEILT
610 620 630 640 650
ALLSDFFVRN EDTSDMIFYI QEKINELAEH LKTLHFNEEL QAEVIADVIT
660 670 680 690 700
MQLEDAPNSL KFLAGKVNFC TLLPMRSVPF KVVCLLGMND ADYPRTQTPN
710 720 730 740 750
SFDLMQYHYQ KGDRVRRDDD RYLFLEALLA ARDYCYISYV GRSITDNQPK
760 770 780 790 800
EPSVLVSQLL DYINQGQKEN VLTVIEHPMT AFSPDNFKNN EKFTRSFATK
810 820 830 840 850
WLPIAQFDAS SNNSEFAVTM TENLEKIEEV ELDALVSFVE NPVKFFFEKQ
860 870 880 890 900
LGVYFRDKDE RIADSENFTL SGLDNYSLNN DLIYLDEQNF ADYFRQAEVK
910 920 930 940 950
GVLPRAEFGK VYAENIRDNV LEFKKKIADL GEAKHASVDF NLSVDWQNEN
960 970 980 990 1000
QKIRLFGYMD ALFGDDSQVI HWHFAKYKDR YCIRPWIYYL IQCVTQENAV
1010 1020 1030 1040 1050
PAKLITQDKV LELPPIEREV ALAQLQIYVK DYLQSQIEIQ LVPTVRNISD
1060 1070 1080 1090 1100
FIVSDENSVS EKLQELTESN GFGPKADPYW SRVLAQTSRF KQPENIAKLL
1110 1120
KQTKAWFGLL FAQKKTRKTQ S
Length:1,121
Mass (Da):129,669
Last modified:November 1, 1995 - v1
Checksum:iE5070957296AE0D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22596.1.
PIRiG64103.
RefSeqiNP_439102.1. NC_000907.1.
WP_005693290.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22596; AAC22596; HI_0942.
GeneIDi950610.
KEGGihin:HI0942.
PATRICi20190541. VBIHaeInf48452_0983.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22596.1.
PIRiG64103.
RefSeqiNP_439102.1. NC_000907.1.
WP_005693290.1. NC_000907.1.

3D structure databases

ProteinModelPortaliP44945.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI0942.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC22596; AAC22596; HI_0942.
GeneIDi950610.
KEGGihin:HI0942.
PATRICi20190541. VBIHaeInf48452_0983.

Phylogenomic databases

eggNOGiENOG4105DSY. Bacteria.
COG1330. LUCA.
KOiK03583.
OMAiSWMRRYP.
OrthoDBiEOG61P6M4.
PhylomeDBiP44945.

Family and domain databases

Gene3Di1.10.10.160. 1 hit.
3.40.50.300. 2 hits.
HAMAPiMF_01486. RecC.
InterProiIPR013986. DExx_box_DNA_helicase_dom.
IPR027417. P-loop_NTPase.
IPR006697. RecC.
IPR011335. Restrct_endonuc-II-like.
[Graphical view]
PIRSFiPIRSF000980. RecC. 1 hit.
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF52980. SSF52980. 1 hit.
TIGRFAMsiTIGR01450. recC. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiRECC_HAEIN
AccessioniPrimary (citable) accession number: P44945
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 17, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.