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Protein

Formate-dependent nitrite reductase complex bifunctional subunit NrfFG

Gene

nrfF

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Possible subunit of a heme lyase.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei61Heme (covalent)Sequence analysis1
Binding sitei64Heme (covalent)Sequence analysis1

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Formate-dependent nitrite reductase complex bifunctional subunit NrfFG
Gene namesi
Name:nrfF
Ordered Locus Names:HI_0934
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35Sequence analysisAdd BLAST35
ChainiPRO_000000661636 – 384Formate-dependent nitrite reductase complex bifunctional subunit NrfFGAdd BLAST349

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0934.

Structurei

3D structure databases

ProteinModelPortaliP44942.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati221 – 254TPR 1Add BLAST34
Repeati255 – 288TPR 2Add BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni36 – 144NrfFAdd BLAST109
Regioni180 – 384NrfGAdd BLAST205

Sequence similaritiesi

Belongs to the CcmH/CycL/Ccl2/NrfF family.Curated
Contains 2 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, TPR repeat

Phylogenomic databases

eggNOGiENOG4108DMF. Bacteria.
COG3088. LUCA.
COG4235. LUCA.
KOiK04017.
K04018.
OMAiEQVIARM.
PhylomeDBiP44942.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR005616. CcmH/CycL/Ccl2/NrfF.
IPR017565. For-dep_Cytc_NO2Rdtase_NrfF.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF03918. CcmH. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 1 hit.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
TIGRFAMsiTIGR03147. cyt_nit_nrfF. 1 hit.
PROSITEiPS50005. TPR. 1 hit.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P44942-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSILDIFTR GFIQVQKTVF FATALLFAFS LFTQAEMVDT YQFQNQDDRT
60 70 80 90 100
RAVELAKSLR CPQCQNQNLV ESNSPIAYDL RLEVYKMVDE GKSNQQIIDK
110 120 130 140 150
MTARFGDFVN YKPPFKWNTA LLWLLPVALL ILAAVLLYFS NRKKQFSEKV
160 170 180 190 200
VAQQLENDEI ISLPSTFGSS PRKQGEPSKL SKGKVNSKIY FVLFTLLIAI
210 220 230 240 250
PATYYFSLDR FSRVQQGEQS MIEQHNQNVE MNDEHKNENV IEKLQNKLRT
260 270 280 290 300
DPNNAETWLQ LGEAYVQNNE FDSALVAYSN AEKLSGSKPN ILGLAATALY
310 320 330 340 350
YQAGQQMTQK VEQLLNEALA KDKNEVSSLS LLATIALENR QYQQAGMYLQ
360 370 380
QLLDSGNAAV DRRSVIQRMK MLDFLQRGEK GQNP
Length:384
Mass (Da):43,780
Last modified:June 6, 2002 - v2
Checksum:i0321F4A7704964C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22592.1.
PIRiH64161.
RefSeqiNP_439094.1. NC_000907.1.
WP_005693281.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22592; AAC22592; HI_0934.
GeneIDi949938.
KEGGihin:HI0934.
PATRICi20190525. VBIHaeInf48452_0975.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22592.1.
PIRiH64161.
RefSeqiNP_439094.1. NC_000907.1.
WP_005693281.1. NC_000907.1.

3D structure databases

ProteinModelPortaliP44942.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI0934.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC22592; AAC22592; HI_0934.
GeneIDi949938.
KEGGihin:HI0934.
PATRICi20190525. VBIHaeInf48452_0975.

Phylogenomic databases

eggNOGiENOG4108DMF. Bacteria.
COG3088. LUCA.
COG4235. LUCA.
KOiK04017.
K04018.
OMAiEQVIARM.
PhylomeDBiP44942.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR005616. CcmH/CycL/Ccl2/NrfF.
IPR017565. For-dep_Cytc_NO2Rdtase_NrfF.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF03918. CcmH. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 1 hit.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
TIGRFAMsiTIGR03147. cyt_nit_nrfF. 1 hit.
PROSITEiPS50005. TPR. 1 hit.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNRFF_HAEIN
AccessioniPrimary (citable) accession number: P44942
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: June 6, 2002
Last modified: October 5, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.