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P44937

- CDSA_HAEIN

UniProt

P44937 - CDSA_HAEIN

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Protein

Phosphatidate cytidylyltransferase

Gene
cdsA, cds, HI_0919
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

Pathwayi

GO - Molecular functioni

  1. phosphatidate cytidylyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. CDP-diacylglycerol biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00557; UER00614.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidate cytidylyltransferase (EC:2.7.7.41)
Alternative name(s):
CDP-DAG synthase
CDP-DG synthase
CDP-diacylglycerol synthase
Short name:
CDS
CDP-diglyceride pyrophosphorylase
CDP-diglyceride synthase
CTP:phosphatidate cytidylyltransferase
Gene namesi
Name:cdsA
Synonyms:cds
Ordered Locus Names:HI_0919
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei10 – 3021Helical; Reviewed predictionAdd
BLAST
Transmembranei52 – 7221Helical; Reviewed predictionAdd
BLAST
Transmembranei89 – 10921Helical; Reviewed predictionAdd
BLAST
Transmembranei118 – 13821Helical; Reviewed predictionAdd
BLAST
Transmembranei152 – 17221Helical; Reviewed predictionAdd
BLAST
Transmembranei192 – 21221Helical; Reviewed predictionAdd
BLAST
Transmembranei223 – 24321Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Phosphatidate cytidylyltransferasePRO_0000090736Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0919.

Family & Domainsi

Sequence similaritiesi

Belongs to the CDS family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0575.
KOiK00981.
OMAiYVFILVW.
OrthoDBiEOG6TBHJT.
PhylomeDBiP44937.

Family and domain databases

InterProiIPR000374. PC_trans.
[Graphical view]
PfamiPF01148. CTP_transf_1. 1 hit.
[Graphical view]
PROSITEiPS01315. CDS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P44937-1 [UniParc]FASTAAdd to Basket

« Hide

MLKQRVLSAI VLIAAVLCAL FLFTPFYFAL ALGAVAILGI WEWTQFARLK    50
QPLIRFFVTT FLGVFIFLWL YTEGNYLDAG RVFEQHLQLL LINAVSWWGL 100
ALLLVISYPK SAKFWSKNPL LQLLFAFSTL IPFVAGVLRL RLEHYTHDPY 150
HGLFLLLYVF ILVWAADSGA YFSGRAFGKR KLAPKVSPGK SWEGVIGGLI 200
TALVLAFIFI HFSNNTLVGD RNITGFIILS VATVAISVLG DLTESMFKRE 250
SGVKDSSQLI PGHGGVLDRI DSLTAAVPFF SYFYFFVL 288
Length:288
Mass (Da):32,247
Last modified:November 1, 1995 - v1
Checksum:i67FFBF29997FAFA5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti16 – 161V → F in strain: Eagan.
Natural varianti59 – 591T → A in strain: 33.
Natural varianti81 – 811R → H in strain: Eagan.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22577.1.
U60831 Genomic DNA. Translation: AAB61967.1.
U60832 Genomic DNA. Translation: AAB61972.1.
PIRiG64102.
RefSeqiNP_439079.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22577; AAC22577; HI_0919.
GeneIDi949391.
KEGGihin:HI0919.
PATRICi20190493. VBIHaeInf48452_0960.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22577.1 .
U60831 Genomic DNA. Translation: AAB61967.1 .
U60832 Genomic DNA. Translation: AAB61972.1 .
PIRi G64102.
RefSeqi NP_439079.1. NC_000907.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0919.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC22577 ; AAC22577 ; HI_0919 .
GeneIDi 949391.
KEGGi hin:HI0919.
PATRICi 20190493. VBIHaeInf48452_0960.

Phylogenomic databases

eggNOGi COG0575.
KOi K00981.
OMAi YVFILVW.
OrthoDBi EOG6TBHJT.
PhylomeDBi P44937.

Enzyme and pathway databases

UniPathwayi UPA00557 ; UER00614 .

Family and domain databases

InterProi IPR000374. PC_trans.
[Graphical view ]
Pfami PF01148. CTP_transf_1. 1 hit.
[Graphical view ]
PROSITEi PS01315. CDS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
  2. Loosmore S.M., Yang Y., Coleman D.C., Shortreed J.M., England D.M., Klein M.H.
    Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 33 and Eagan / Serotype B.

Entry informationi

Entry nameiCDSA_HAEIN
AccessioniPrimary (citable) accession number: P44937
Secondary accession number(s): O32623, O32627
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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