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P44937

- CDSA_HAEIN

UniProt

P44937 - CDSA_HAEIN

Protein

Phosphatidate cytidylyltransferase

Gene

cdsA

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

    Pathwayi

    GO - Molecular functioni

    1. phosphatidate cytidylyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. CDP-diacylglycerol biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

    Enzyme and pathway databases

    UniPathwayiUPA00557; UER00614.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidate cytidylyltransferase (EC:2.7.7.41)
    Alternative name(s):
    CDP-DAG synthase
    CDP-DG synthase
    CDP-diacylglycerol synthase
    Short name:
    CDS
    CDP-diglyceride pyrophosphorylase
    CDP-diglyceride synthase
    CTP:phosphatidate cytidylyltransferase
    Gene namesi
    Name:cdsA
    Synonyms:cds
    Ordered Locus Names:HI_0919
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 288288Phosphatidate cytidylyltransferasePRO_0000090736Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi71421.HI0919.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei10 – 3021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei52 – 7221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei89 – 10921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei118 – 13821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei152 – 17221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei192 – 21221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei223 – 24321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CDS family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0575.
    KOiK00981.
    OMAiYVFILVW.
    OrthoDBiEOG6TBHJT.
    PhylomeDBiP44937.

    Family and domain databases

    InterProiIPR000374. PC_trans.
    [Graphical view]
    PfamiPF01148. CTP_transf_1. 1 hit.
    [Graphical view]
    PROSITEiPS01315. CDS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P44937-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLKQRVLSAI VLIAAVLCAL FLFTPFYFAL ALGAVAILGI WEWTQFARLK    50
    QPLIRFFVTT FLGVFIFLWL YTEGNYLDAG RVFEQHLQLL LINAVSWWGL 100
    ALLLVISYPK SAKFWSKNPL LQLLFAFSTL IPFVAGVLRL RLEHYTHDPY 150
    HGLFLLLYVF ILVWAADSGA YFSGRAFGKR KLAPKVSPGK SWEGVIGGLI 200
    TALVLAFIFI HFSNNTLVGD RNITGFIILS VATVAISVLG DLTESMFKRE 250
    SGVKDSSQLI PGHGGVLDRI DSLTAAVPFF SYFYFFVL 288
    Length:288
    Mass (Da):32,247
    Last modified:November 1, 1995 - v1
    Checksum:i67FFBF29997FAFA5
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti16 – 161V → F in strain: Eagan.
    Natural varianti59 – 591T → A in strain: 33.
    Natural varianti81 – 811R → H in strain: Eagan.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22577.1.
    U60831 Genomic DNA. Translation: AAB61967.1.
    U60832 Genomic DNA. Translation: AAB61972.1.
    PIRiG64102.
    RefSeqiNP_439079.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC22577; AAC22577; HI_0919.
    GeneIDi949391.
    KEGGihin:HI0919.
    PATRICi20190493. VBIHaeInf48452_0960.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22577.1 .
    U60831 Genomic DNA. Translation: AAB61967.1 .
    U60832 Genomic DNA. Translation: AAB61972.1 .
    PIRi G64102.
    RefSeqi NP_439079.1. NC_000907.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI0919.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC22577 ; AAC22577 ; HI_0919 .
    GeneIDi 949391.
    KEGGi hin:HI0919.
    PATRICi 20190493. VBIHaeInf48452_0960.

    Phylogenomic databases

    eggNOGi COG0575.
    KOi K00981.
    OMAi YVFILVW.
    OrthoDBi EOG6TBHJT.
    PhylomeDBi P44937.

    Enzyme and pathway databases

    UniPathwayi UPA00557 ; UER00614 .

    Family and domain databases

    InterProi IPR000374. PC_trans.
    [Graphical view ]
    Pfami PF01148. CTP_transf_1. 1 hit.
    [Graphical view ]
    PROSITEi PS01315. CDS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
    2. Loosmore S.M., Yang Y., Coleman D.C., Shortreed J.M., England D.M., Klein M.H.
      Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 33 and Eagan / Serotype B.

    Entry informationi

    Entry nameiCDSA_HAEIN
    AccessioniPrimary (citable) accession number: P44937
    Secondary accession number(s): O32623, O32627
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3