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P44937 (CDSA_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphatidate cytidylyltransferase

EC=2.7.7.41
Alternative name(s):
CDP-DAG synthase
CDP-DG synthase
CDP-diacylglycerol synthase
Short name=CDS
CDP-diglyceride pyrophosphorylase
CDP-diglyceride synthase
CTP:phosphatidate cytidylyltransferase
Gene names
Name:cdsA
Synonyms:cds
Ordered Locus Names:HI_0919
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length288 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

Pathway

Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the CDS family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 288288Phosphatidate cytidylyltransferase
PRO_0000090736

Regions

Transmembrane10 – 3021Helical; Potential
Transmembrane52 – 7221Helical; Potential
Transmembrane89 – 10921Helical; Potential
Transmembrane118 – 13821Helical; Potential
Transmembrane152 – 17221Helical; Potential
Transmembrane192 – 21221Helical; Potential
Transmembrane223 – 24321Helical; Potential

Natural variations

Natural variant161V → F in strain: Eagan.
Natural variant591T → A in strain: 33.
Natural variant811R → H in strain: Eagan.

Sequences

Sequence LengthMass (Da)Tools
P44937 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 67FFBF29997FAFA5

FASTA28832,247
        10         20         30         40         50         60 
MLKQRVLSAI VLIAAVLCAL FLFTPFYFAL ALGAVAILGI WEWTQFARLK QPLIRFFVTT 

        70         80         90        100        110        120 
FLGVFIFLWL YTEGNYLDAG RVFEQHLQLL LINAVSWWGL ALLLVISYPK SAKFWSKNPL 

       130        140        150        160        170        180 
LQLLFAFSTL IPFVAGVLRL RLEHYTHDPY HGLFLLLYVF ILVWAADSGA YFSGRAFGKR 

       190        200        210        220        230        240 
KLAPKVSPGK SWEGVIGGLI TALVLAFIFI HFSNNTLVGD RNITGFIILS VATVAISVLG 

       250        260        270        280 
DLTESMFKRE SGVKDSSQLI PGHGGVLDRI DSLTAAVPFF SYFYFFVL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC22577.1.
U60831 Genomic DNA. Translation: AAB61967.1.
U60832 Genomic DNA. Translation: AAB61972.1.
PIRG64102.
RefSeqNP_439079.1. NC_000907.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID949391.
GenomeReviewsGene locus HI_0919 in contig L42023_GR.
KEGGhin:HI0919.
NMPDRfig|71421.1.peg.885.
PATRIC20190493. VBIHaeInf48452_0960.
TIGRHI_0919.

Phylogenomic databases

HOGENOMHBG732679.
OMAKDSSQLI.
ProtClustDBCLSK870687.

Enzyme and pathway databases

BioCycHINF71421:HI_0919-MONOMER.

Family and domain databases

InterProIPR000374. PC_trans.
[Graphical view]
KOK00981.
PfamPF01148. CTP_transf_1. 1 hit.
[Graphical view]
PROSITEPS01315. CDS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCDSA_HAEIN
AccessionPrimary (citable) accession number: P44937
Secondary accession number(s): O32623, O32627
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 25, 2012
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families