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P44931

- TADA_HAEIN

UniProt

P44931 - TADA_HAEIN

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Protein

tRNA-specific adenosine deaminase

Gene
tadA, HI_0906
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) By similarity.UniRule annotation

Catalytic activityi

Adenine(34) in tRNA + H2O = hypoxanthine(34) in tRNA + NH3.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi61 – 611Zinc; via pros nitrogen; catalytic By similarity
Active sitei63 – 631Proton donor By similarity
Metal bindingi91 – 911Zinc; catalytic By similarity
Metal bindingi94 – 941Zinc; catalytic By similarity

GO - Molecular functioni

  1. tRNA-specific adenosine-34 deaminase activity Source: UniProtKB-HAMAP
  2. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. tRNA wobble adenosine to inosine editing Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA-specific adenosine deaminase (EC:3.5.4.33)
Gene namesi
Name:tadA
Ordered Locus Names:HI_0906
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 173173tRNA-specific adenosine deaminaseUniRule annotationPRO_0000171739Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi71421.HI0906.

Structurei

3D structure databases

ProteinModelPortaliP44931.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 109100CMP/dCMP deaminase zinc-bindingAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0590.
KOiK11991.
OMAiIMCAGAM.
OrthoDBiEOG64FKGZ.
PhylomeDBiP44931.

Family and domain databases

HAMAPiMF_00972. tRNA_aden_deaminase.
InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
IPR028883. tRNA_aden_deaminase.
[Graphical view]
PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view]
SUPFAMiSSF53927. SSF53927. 1 hit.
PROSITEiPS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P44931-1 [UniParc]FASTAAdd to Basket

« Hide

MDAAKVRSEF DEKMMRYALE LADKAEALGE IPVGAVLVDD ARNIIGEGWN    50
LSIVQSDPTA HAEIIALRNG AKNIQNYRLL NSTLYVTLEP CTMCAGAILH 100
SRIKRLVFGA SDYKTGAIGS RFHFFDDYKM NHTLEVTSGV LAEECSQKLS 150
TFFQKRREEK KIEKALLKSL SDK 173
Length:173
Mass (Da):19,359
Last modified:November 1, 1995 - v1
Checksum:i785E2CE532FB72DE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22565.1.
PIRiC64161.
RefSeqiNP_439066.1. NC_000907.1.
WP_005693256.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22565; AAC22565; HI_0906.
GeneIDi949908.
KEGGihin:HI0906.
PATRICi20190467. VBIHaeInf48452_0947.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22565.1 .
PIRi C64161.
RefSeqi NP_439066.1. NC_000907.1.
WP_005693256.1. NC_000907.1.

3D structure databases

ProteinModelPortali P44931.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0906.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC22565 ; AAC22565 ; HI_0906 .
GeneIDi 949908.
KEGGi hin:HI0906.
PATRICi 20190467. VBIHaeInf48452_0947.

Phylogenomic databases

eggNOGi COG0590.
KOi K11991.
OMAi IMCAGAM.
OrthoDBi EOG64FKGZ.
PhylomeDBi P44931.

Family and domain databases

HAMAPi MF_00972. tRNA_aden_deaminase.
InterProi IPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
IPR028883. tRNA_aden_deaminase.
[Graphical view ]
Pfami PF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view ]
SUPFAMi SSF53927. SSF53927. 1 hit.
PROSITEi PS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiTADA_HAEIN
AccessioniPrimary (citable) accession number: P44931
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 3, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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