Dephospho-CoA kinase - Haemophilus influenzae

Names and origin

Protein names

Recommended name:
    Dephospho-CoA kinase
    EC=2.7.1.24
Alternative name(s):
    Dephosphocoenzyme A kinase

Gene names

Name:	coaE
Ordered Locus Names:	HI0890

Organism

Haemophilus influenzae [Complete proteome] [HAMAP]

Taxonomic identifier

727 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

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Protein attributes

Sequence length	206 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A By similarity.
Catalytic activity	ATP + 3'-dephospho-CoA = ADP + CoA. HAMAP MF_00376
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; coenzyme A from pantothenate: step 5/5. HAMAP MF_00376
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the coaE family. Contains 1 DPCK (dephospho-CoA kinase) domain.

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Ontologies

Keywords
Biological process	Coenzyme A biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP dephospho-CoA kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 206

206

Dephospho-CoA kinase HAMAP MF_00376

PRO_0000172947

Regions

Domain

4 – 204

201

DPCK

Nucleotide binding

9 – 16

8

ATP Potential

Secondary structure

1

.

206

Helix Strand Turn

Details...

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Sequences

Sequence

Length

Mass (Da)

Tools

P44920-1 [UniParc].

Last modified June 1, 2001. Version 2.
Checksum: DF85B65D50131C01
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FASTA

206

23,287

        10         20         30         40         50         60 
MTYIVGLTGG IGSGKTTIAN LFTDLGVPLV DADVVAREVV AKDSPLLSKI VEHFGAQILT 

        70         80         90        100        110        120 
EQGELNRAAL RERVFNHDED KLWLNNLLHP AIRERMKQKL AEQTAPYTLF VVPLLIENKL 

       130        140        150        160        170        180 
TALCDRILVV DVSPQTQLAR SAQRDNNNFE QIQRIMNSQV SQQERLKWAD DVINNDAELA 

       190        200 
QNLPHLQQKV LELHQFYLQQ AENKNA

« Hide

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References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd."
Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I.

Venter J.C.
Science 269:496-512(1995) [PubMed: 7542800] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

+

Additional computationally mapped references.

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Cross-references

Sequence databases

L42023 Genomic DNA. Translation: AAC22550.1. Different initiation.

PIR

A64161.

RefSeq

NP_439051.1.

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1JJV	X-ray	2.00	A	1-206	[»]

ModBase

Search...

Genome annotation databases

GeneID

950766.

GenomeReviews

Gene locus HI0890 in contig L42023_GR.

NMPDR

fig|71421.1.peg.857.

TIGR

HI0890.

Phylogenomic databases

HOGENOM

P44920.

Enzyme and pathway databases

BioCyc

HINF71421:HI_0890-MON.

BRENDA

2.7.1.24. 109.

Family and domain databases

HAMAP

MF_00376.
[Tree]

InterPro

IPR001977. Depp_CoAkinase.
[Graphical view]

PANTHER

PTHR10695. Depp_CoAkinase. 1 hit.

Pfam

PF01121. CoaE. 1 hit.
[Graphical view]

ProDom

PD003329. Depp_CoAkinase. 1 hit.
[Graphical view] [Entries sharing at least one domain]

TIGRFAMs

TIGR00152. Depp_CoAkinase. 1 hit.

PROSITE

PS51219. DPCK. 1 hit.
[Graphical view]

ProtoNet

Search...

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Entry information

Entry name

COAE_HAEIN

Accession

Primary (citable) accession number: P44920

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	June 1, 2001
Last modified:	June 16, 2009
This is version 73 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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