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Protein

Dephospho-CoA kinase

Gene

coaE

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.By similarity

Catalytic activityi

ATP + 3'-dephospho-CoA = ADP + CoA.

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes CoA from (R)-pantothenate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Pantothenate kinase (coaA)
  2. Coenzyme A biosynthesis bifunctional protein CoaBC (coaBC)
  3. Coenzyme A biosynthesis bifunctional protein CoaBC (coaBC)
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 16ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Coenzyme A biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.24. 2529.
UniPathwayiUPA00241; UER00356.

Names & Taxonomyi

Protein namesi
Recommended name:
Dephospho-CoA kinase (EC:2.7.1.24)
Alternative name(s):
Dephosphocoenzyme A kinase
Gene namesi
Name:coaE
Ordered Locus Names:HI_0890
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001729471 – 206Dephospho-CoA kinaseAdd BLAST206

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0890m.

Structurei

Secondary structure

1206
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 8Combined sources6
Helixi15 – 23Combined sources9
Turni24 – 26Combined sources3
Beta strandi29 – 31Combined sources3
Helixi32 – 38Combined sources7
Helixi45 – 54Combined sources10
Helixi67 – 75Combined sources9
Helixi78 – 101Combined sources24
Beta strandi105 – 111Combined sources7
Turni113 – 119Combined sources7
Helixi121 – 123Combined sources3
Beta strandi125 – 131Combined sources7
Helixi134 – 141Combined sources8
Helixi149 – 158Combined sources10
Helixi162 – 168Combined sources7
Beta strandi170 – 174Combined sources5
Helixi179 – 203Combined sources25

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JJVX-ray2.00A1-206[»]
ProteinModelPortaliP44920.
SMRiP44920.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP44920.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 204DPCKAdd BLAST201

Sequence similaritiesi

Belongs to the CoaE family.Curated

Phylogenomic databases

eggNOGiENOG4108ZQD. Bacteria.
COG0237. LUCA.
KOiK00859.
OMAiKKRYPVS.
PhylomeDBiP44920.

Family and domain databases

CDDicd02022. DPCK. 1 hit.
Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00376. Dephospho_CoA_kinase. 1 hit.
InterProiIPR001977. Depp_CoAkinase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01121. CoaE. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00152. TIGR00152. 1 hit.
PROSITEiPS51219. DPCK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P44920-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTYIVGLTGG IGSGKTTIAN LFTDLGVPLV DADVVAREVV AKDSPLLSKI
60 70 80 90 100
VEHFGAQILT EQGELNRAAL RERVFNHDED KLWLNNLLHP AIRERMKQKL
110 120 130 140 150
AEQTAPYTLF VVPLLIENKL TALCDRILVV DVSPQTQLAR SAQRDNNNFE
160 170 180 190 200
QIQRIMNSQV SQQERLKWAD DVINNDAELA QNLPHLQQKV LELHQFYLQQ

AENKNA
Length:206
Mass (Da):23,287
Last modified:June 1, 2001 - v2
Checksum:iDF85B65D50131C01
GO

Sequence cautioni

The sequence AAC22550 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22550.1. Different initiation.
PIRiA64161.
RefSeqiNP_439051.1. NC_000907.1.
WP_010869082.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22550; AAC22550; HI_0890.
GeneIDi950766.
KEGGihin:HI0890m.
PATRICi20190437. VBIHaeInf48452_0932.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22550.1. Different initiation.
PIRiA64161.
RefSeqiNP_439051.1. NC_000907.1.
WP_010869082.1. NC_000907.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JJVX-ray2.00A1-206[»]
ProteinModelPortaliP44920.
SMRiP44920.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI0890m.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC22550; AAC22550; HI_0890.
GeneIDi950766.
KEGGihin:HI0890m.
PATRICi20190437. VBIHaeInf48452_0932.

Phylogenomic databases

eggNOGiENOG4108ZQD. Bacteria.
COG0237. LUCA.
KOiK00859.
OMAiKKRYPVS.
PhylomeDBiP44920.

Enzyme and pathway databases

UniPathwayiUPA00241; UER00356.
BRENDAi2.7.1.24. 2529.

Miscellaneous databases

EvolutionaryTraceiP44920.

Family and domain databases

CDDicd02022. DPCK. 1 hit.
Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00376. Dephospho_CoA_kinase. 1 hit.
InterProiIPR001977. Depp_CoAkinase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01121. CoaE. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00152. TIGR00152. 1 hit.
PROSITEiPS51219. DPCK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOAE_HAEIN
AccessioniPrimary (citable) accession number: P44920
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.