P44920 (COAE_HAEIN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 90.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Dephospho-CoA kinase EC=2.7.1.24 Alternative name(s): Dephosphocoenzyme A kinase | ||||
| Gene names |
| ||||
| Organism | Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) | ||||
| Taxonomic identifier | 71421 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus |
Protein attributes
| Sequence length | 206 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A By similarity. HAMAP MF_00376 |
| Catalytic activity | ATP + 3'-dephospho-CoA = ADP + CoA. HAMAP MF_00376 |
| Pathway | Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5. HAMAP MF_00376 |
| Subcellular location | Cytoplasm By similarity HAMAP MF_00376. |
| Sequence similarities | Belongs to the CoaE family. Contains 1 DPCK (dephospho-CoA kinase) domain. |
| Sequence caution | The sequence AAC22550.1 differs from that shown. Reason: Erroneous initiation. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Coenzyme A biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Transferase |
| Technical term | 3D-structure Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | coenzyme A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW dephospho-CoA kinase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||||||||||||||||||||||||
Molecule processing | |||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 206 | 206 | Dephospho-CoA kinase HAMAP MF_00376 | PRO_0000172947 | |||||||||||||||||||||||||||||||||||||
Regions | |||||||||||||||||||||||||||||||||||||||||
| Domain | 4 – 204 | 201 | DPCK | ||||||||||||||||||||||||||||||||||||||
| Nucleotide binding | 9 – 16 | 8 | ATP Potential | ||||||||||||||||||||||||||||||||||||||
Secondary structure | |||||||||||||||||||||||||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||||||||||||||||||||||||
| Beta strand | 3 – 8 | 6 | |||||||||||||||||||||||||||||||||||||||
| Helix | 15 – 23 | 9 | |||||||||||||||||||||||||||||||||||||||
| Turn | 24 – 26 | 3 | |||||||||||||||||||||||||||||||||||||||
| Beta strand | 29 – 31 | 3 | |||||||||||||||||||||||||||||||||||||||
| Helix | 32 – 38 | 7 | |||||||||||||||||||||||||||||||||||||||
| Helix | 45 – 54 | 10 | |||||||||||||||||||||||||||||||||||||||
| Helix | 67 – 75 | 9 | |||||||||||||||||||||||||||||||||||||||
| Helix | 78 – 101 | 24 | |||||||||||||||||||||||||||||||||||||||
| Beta strand | 105 – 111 | 7 | |||||||||||||||||||||||||||||||||||||||
| Turn | 113 – 119 | 7 | |||||||||||||||||||||||||||||||||||||||
| Helix | 121 – 123 | 3 | |||||||||||||||||||||||||||||||||||||||
| Beta strand | 125 – 131 | 7 | |||||||||||||||||||||||||||||||||||||||
| Helix | 134 – 141 | 8 | |||||||||||||||||||||||||||||||||||||||
| Helix | 149 – 158 | 10 | |||||||||||||||||||||||||||||||||||||||
| Helix | 162 – 168 | 7 | |||||||||||||||||||||||||||||||||||||||
| Beta strand | 170 – 174 | 5 | |||||||||||||||||||||||||||||||||||||||
| Helix | 179 – 203 | 25 | |||||||||||||||||||||||||||||||||||||||
Sequences
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References
| [1] | "Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. Venter J.C.Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | L42023 Genomic DNA. Translation: AAC22550.1. Different initiation. | ||||||||||||
| PIR | A64161. | ||||||||||||
| RefSeq | NP_439051.1. NC_000907.1. | ||||||||||||
3D structure databases | |||||||||||||
| PDBe RCSB PDB PDBj |
| ||||||||||||
| ProteinModelPortal | P44920. | ||||||||||||
| SMR | P44920. Positions 1-205. | ||||||||||||
| ModBase | Search... | ||||||||||||
Protocols and materials databases | |||||||||||||
| StructuralBiologyKnowledgebase | Search... | ||||||||||||
Genome annotation databases | |||||||||||||
| GeneID | 950766. | ||||||||||||
| GenomeReviews | Gene locus HI_0890 in contig L42023_GR. | ||||||||||||
| NMPDR | fig|71421.1.peg.857. | ||||||||||||
| PATRIC | 20190437. VBIHaeInf48452_0932. | ||||||||||||
| TIGR | HI_0890. | ||||||||||||
Phylogenomic databases | |||||||||||||
| HOGENOM | HBG650290. | ||||||||||||
| OMA | YVIMVVP. | ||||||||||||
| PhylomeDB | P44920. | ||||||||||||
| ProtClustDB | PRK00081. | ||||||||||||
Enzyme and pathway databases | |||||||||||||
| BioCyc | HINF71421:HI_0890-MONOMER. | ||||||||||||
Family and domain databases | |||||||||||||
| HAMAP | MF_00376. Dephospho_CoA_kinase. [Tree] | ||||||||||||
| InterPro | IPR001977. Depp_CoAkinase. [Graphical view] | ||||||||||||
| Pfam | PF01121. CoaE. 1 hit. [Graphical view] | ||||||||||||
| TIGRFAMs | TIGR00152. TIGR00152. 1 hit. | ||||||||||||
| PROSITE | PS51219. DPCK. 1 hit. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Entry information
| Entry name | COAE_HAEIN | ||||||||
| Accession | Primary (citable) accession number: P44920 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| Haemophilus influenzae Haemophilus influenzae (strain Rd): entries and gene names |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

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