Thiol:disulfide interchange protein dsbD precursor

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Reviewed, UniProtKB/Swiss-Prot P44919 (DSBD_HAEIN)

Last modified June 16, 2009. Version 72. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Thiol:disulfide interchange protein dsbD
    EC=1.8.1.8
Alternative name(s):
    Protein-disulfide reductase
      Short name=Disulfide reductase
    C-type cytochrome biogenesis protein cycZ

Gene names

Name:	dsbD
Synonyms:	cycZ
Ordered Locus Names:	HI0885

Organism

Haemophilus influenzae [Complete proteome] [HAMAP]

Taxonomic identifier

727 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

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Protein attributes

Sequence length	579 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

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General annotation (Comments)

Function	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps By similarity.
Catalytic activity	Protein dithiol + NAD(P)⁺ = protein disulfide + NAD(P)H. HAMAP MF_00399
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the thioredoxin family. DsbD subfamily. Contains 1 thioredoxin domain.

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Ontologies

Keywords
Biological process	Cytochrome c-type biogenesis Electron transport Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Redox-active center Signal Transmembrane
Ligand	NAD
Molecular function	Oxidoreductase
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro cytochrome complex assembly Inferred from electronic annotation. Source: HAMAP electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	electron carrier activity Inferred from electronic annotation. Source: HAMAP protein-disulfide reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 16

Potential

Chain

17 – 579

563

Thiol:disulfide interchange protein dsbD HAMAP MF_00399

PRO_0000007376

Regions

Topological domain

17 – 177

161

Periplasmic Potential

Transmembrane

178 – 198

Potential

Topological domain

199 – 229

Cytoplasmic Potential

Transmembrane

230 – 250

Potential

Topological domain

251 – 253

Periplasmic Potential

Transmembrane

254 – 274

Potential

Topological domain

275 – 295

Cytoplasmic Potential

Transmembrane

296 – 316

Potential

Topological domain

317 – 336

Periplasmic Potential

Transmembrane

337 – 357

Potential

Topological domain

358 – 367

Cytoplasmic Potential

Transmembrane

368 – 388

Potential

Topological domain

389 – 396

Periplasmic Potential

Transmembrane

397 – 417

Potential

Topological domain

418 – 419

Cytoplasmic Potential

Transmembrane

420 – 440

Potential

Topological domain

441 – 579

139

Periplasmic Potential

Domain

449 – 579

131

Thioredoxin

Amino acid modifications

Disulfide bond

124 ↔ 129

Redox-active By similarity

Disulfide bond

193 ↔ 315

Redox-active By similarity

Disulfide bond

495 ↔ 498

Redox-active By similarity

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Sequences

Sequence

Length

Mass (Da)

Tools

P44919-1 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 2D2D1359E2246310
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FASTA

579

64,406

        10         20         30         40         50         60 
MKKLFLFFTL IFTAFAANSG LFDKKQTFLK VDDAFAFSAT LSTDKSQLQA HWDIADGYYL 

        70         80         90        100        110        120 
YQDKISAELV GKSNPLSLHT QQAAELHQDP YFGEVKVFTH SIDGIFRGAF NNADDKVEIT 

       130        140        150        160        170        180 
YQGCTEGFCY PPETKVLRIG DLVVSQKQIV EKTVEKNTAL LSEQDRLADG LFHSKWAIFG 

       190        200        210        220        230        240 
FFVLGLGLAF TPCVLPMLPL LSAIVIGQQQ RPNMMRAFSL AFLYVQGMAL TYTLLGLAVA 

       250        260        270        280        290        300 
AIGLPFQIAL QHPYVMIGLS ILFVALALSM FGLFTIQLPN SLQNKLNTWS QKQTSGAFGG 

       310        320        330        340        350        360 
AFAMGMIAGL VASPCTSAPL SGALLYVAQS GDLFTGAVTL YLLALGMGVP LMLITLFGNK 

       370        380        390        400        410        420 
ILPKSGEWMN TVKQTFGFVM LALPVFLLSR ILPEVWEPRL WAGLATVFFI WFALQMSKNG 

       430        440        450        460        470        480 
FGYAIKIISF ALAMVTVQPL QNWIWQTQTT TQSAVENMPV SQVKFKQIKN TEELDRTLAE 

       490        500        510        520        530        540 
NPHSIAMLDL YADWCVACKE FEKLTFSDPQ VQQQFQNILL LQVSMTKNSP ENKALMERFN 

       550        560        570 
VMGLPTILFF DQQNNEIKGS RVTGFMDADA FSNWIEKLL

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Cross-references

Sequence databases
	L42023 Genomic DNA. Translation: AAC22543.1.
PIR	A64100.
RefSeq	NP_439046.1.
3D structure databases
HSSP	HSSP built from PDB template 1JPE based on UniProtKB P36655.
ModBase	Search...
Genome annotation databases
GeneID	950312.
GenomeReviews	Gene locus HI0885 in contig L42023_GR.
KEGG	hin:HI0885.
NMPDR	fig\|71421.1.peg.852.
TIGR	HI0885.
Phylogenomic databases
HOGENOM	P44919.
OMA	P44919. PVFLLSR.
Enzyme and pathway databases
BioCyc	HINF71421:HI_0885-MON.
BRENDA	1.8.1.8. 109.
Family and domain databases
HAMAP	MF_00399. [Tree]
InterPro	IPR003834. Cyt_c_assmbl_TM. IPR017936. Thioredoxin-like. IPR017937. Thioredoxin_CS. IPR013766. Thioredoxin_domain. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
Pfam	PF02683. DsbD. 1 hit. PF00085. Thioredoxin. 1 hit. [Graphical view]
PROSITE	PS00194. THIOREDOXIN_1. 1 hit. PS51352. THIOREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

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Entry information

Entry name

DSBD_HAEIN

Accession

Primary (citable) accession number: P44919

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	June 16, 2009
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents