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P44914

- RMLB_HAEIN

UniProt

P44914 - RMLB_HAEIN

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Protein

dTDP-glucose 4,6-dehydratase

Gene
rffG, HI_0873
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction By similarity.

Catalytic activityi

dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O.

Cofactori

Binds 1 NAD per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei81 – 811NAD; via carbonyl oxygen By similarity
Binding sitei85 – 851Substrate; via carbonyl oxygen By similarity
Binding sitei100 – 1001NAD By similarity
Active sitei135 – 1351Proton donor By similarity
Active sitei136 – 1361Proton acceptor By similarity
Active sitei160 – 1601Proton acceptor By similarity
Binding sitei189 – 1891Substrate By similarity
Binding sitei190 – 1901NAD; via amide nitrogen By similarity
Binding sitei224 – 2241Substrate By similarity
Binding sitei259 – 2591Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 147NAD Reviewed prediction
Nucleotide bindingi33 – 364NAD By similarity
Nucleotide bindingi59 – 602NAD By similarity
Nucleotide bindingi160 – 1645NAD By similarity

GO - Molecular functioni

  1. coenzyme binding Source: InterPro
  2. dTDP-glucose 4,6-dehydratase activity Source: UniProtKB

GO - Biological processi

  1. dTDP-rhamnose biosynthetic process Source: UniProtKB-UniPathway
  2. extracellular polysaccharide biosynthetic process Source: UniProtKB
  3. lipopolysaccharide biosynthetic process Source: UniProtKB
  4. O antigen biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Lipopolysaccharide biosynthesis

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00124.
UPA00281.

Names & Taxonomyi

Protein namesi
Recommended name:
dTDP-glucose 4,6-dehydratase (EC:4.2.1.46)
Gene namesi
Name:rffG
Ordered Locus Names:HI_0873
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 338338dTDP-glucose 4,6-dehydratasePRO_0000183237Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi71421.HI0873.

Structurei

3D structure databases

ProteinModelPortaliP44914.
SMRiP44914. Positions 1-336.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni134 – 1363Substrate binding By similarity
Regioni199 – 2002Substrate binding By similarity
Regioni215 – 2173Substrate binding By similarity
Regioni294 – 2974Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1088.
KOiK01710.
OMAiNANIEFR.
OrthoDBiEOG6PZXCX.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR005888. dTDP_Gluc_deHydtase.
IPR001509. Epimerase_deHydtase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR10366:SF41. PTHR10366:SF41. 1 hit.
PfamiPF01370. Epimerase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01181. dTDP_gluc_dehyt. 1 hit.

Sequencei

Sequence statusi: Complete.

P44914-1 [UniParc]FASTAAdd to Basket

« Hide

MMNILVTGGS GFIGSALIRY IINHTQDFVI NIDKLTYAAN QSALREVENN    50
PRYVFEKVDI CDLNVIENIF EKYQPDAVMH LAAESHVDRS ISGAADFVQT 100
NIVGTYTLLE VAKNYWHTLD EAKKTTFRFH HISTDEVYGD LSLSEPAFTE 150
QSPYHPSSPY SASKAASNHL VQAWHRTYGL PVIITNSSNN YGAYQHAEKL 200
IPLMISNAVM GKPLPIYGDG QQIRDWLFVE DHVQASYLVL TKGRVGENYN 250
IGGNCEKTNL EVVKRICQLL EELAPSKPNH IKYYEDLMTF VKDRPGHDVR 300
YSLDCSKIHA ELGWQPQITF EQGLRQTVKW YLFNSSSS 338
Length:338
Mass (Da):38,329
Last modified:November 1, 1995 - v1
Checksum:iB44BCC29D6C7D04B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22531.1.
PIRiC64099.
RefSeqiNP_439034.2. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22531; AAC22531; HI_0873.
GeneIDi949510.
KEGGihin:HI0873.
PATRICi20190401. VBIHaeInf48452_0914.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22531.1 .
PIRi C64099.
RefSeqi NP_439034.2. NC_000907.1.

3D structure databases

ProteinModelPortali P44914.
SMRi P44914. Positions 1-336.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0873.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC22531 ; AAC22531 ; HI_0873 .
GeneIDi 949510.
KEGGi hin:HI0873.
PATRICi 20190401. VBIHaeInf48452_0914.

Phylogenomic databases

eggNOGi COG1088.
KOi K01710.
OMAi NANIEFR.
OrthoDBi EOG6PZXCX.

Enzyme and pathway databases

UniPathwayi UPA00124 .
UPA00281 .

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR005888. dTDP_Gluc_deHydtase.
IPR001509. Epimerase_deHydtase.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR10366:SF41. PTHR10366:SF41. 1 hit.
Pfami PF01370. Epimerase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01181. dTDP_gluc_dehyt. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiRMLB_HAEIN
AccessioniPrimary (citable) accession number: P44914
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 14, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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