Reviewed, UniProtKB/Swiss-Prot P44894 (FRDA_HAEIN)

Names and origin

Protein names

Recommended name:
    Fumarate reductase flavoprotein subunit
    EC=1.3.99.1

Gene names

Name:	frdA
Ordered Locus Names:	HI0835

Organism

Haemophilus influenzae [Complete proteome] [HAMAP]

Taxonomic identifier

727 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	599 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Succinate + acceptor = fumarate + reduced acceptor.
Cofactor	Binds 1 FAD covalently per subunit By similarity.
Subunit structure	Fumarate dehydrogenase forms part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, and two hydrophobic anchor proteins By similarity.
Sequence similarities	Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

Ontologies

Keywords
Biological process	Electron transport Transport
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	anaerobic respiration Inferred from electronic annotation. Source: InterPro electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro electron carrier activity Inferred from electronic annotation. Source: InterPro succinate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 599	599	Fumarate reductase flavoprotein subunit		PRO_0000158661
Regions
	Nucleotide binding	9 – 23	15	FAD Potential
Sites
	Active site	233	1	By similarity
	Active site	249	1	By similarity
Amino acid modifications
	Modified residue	45	1	Tele-8alpha-FAD histidine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P44894-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 30D4D3B10059236F	FASTA	599	65,933
	10 20 30 40 50 60 MQTVNVDIAI VGAGGGGLRA AIAAAEANPN LKIALVSKVY PMRTHTVAAE GGAAAVIKEE 70 80 90 100 110 120 DSYDKHFQDT VAGGDWLCEQ DVVEYFVQHS PVEMTQLERW GCPWSRKADG DVNVRRFGGM 130 140 150 160 170 180 KIERTWFAAD KTGFHLLHTL FQTSIQYPQI QRFDEHFVLD ILVDDGHARG MVAMNMMEGS 190 200 210 220 230 240 LVQINANAVV IATGGGCRAF KFNTNGGIVT GDGLSMAYRH GVPLRDMEFV QYHPTGLPNT 250 260 270 280 290 300 GILMTEGCRG EGGILVNKDG YRYLQDYGLG PETPIGKPQN KYMELGPRDK VSQAFWQEWK 310 320 330 340 350 360 KGNTLKTAKG VDVVHLDLRH LGEKYLHERL PFICELASAY EGVNPVNEPI PVRPVVHYTM 370 380 390 400 410 420 GGIEVDFNSE TRIKGLFAVG ECASSGLHGA NRLGSNSLAE LVVLGRVAGE YAAQRAVEAQ 430 440 450 460 470 480 SVNQSAVDAQ AKDVVARLEA LHKQEGNESW SEIRDEMGTV MEEGCGIYRD QASMQKAVDK 490 500 510 520 530 540 IAELKERYKR IRVSDNSSVF NTDVLYTVEL GYILDVAQSI ANSAIERKES RGAHQRLDYT 550 560 570 580 590 ERDDVNYLKH TLAFYNENGA PRIEYSPVKI TKSQPAKRVY GAEAEAQEAA AKAKEQANG

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L42023 Genomic DNA. Translation: AAC22493.1.
PIR	H64097.
RefSeq	NP_438995.1.
3D structure databases
HSSP	HSSP built from PDB template 1KF6 based on UniProtKB P00363.
SMR	P44894. Positions 1-576.
ModBase	Search...
Genome annotation databases
GeneID	949849.
GenomeReviews	Gene locus HI0835 in contig L42023_GR.
KEGG	hin:HI0835.
NMPDR	fig|71421.1.peg.803.
TIGR	HI0835.
Phylogenomic databases
HOGENOM	P44894.
OMA	P44894. TITKSQP.
Enzyme and pathway databases
BioCyc	HINF71421:HI_0835-MON.
BRENDA	1.3.99.1. 109.
Family and domain databases
InterPro	IPR003953. FAD_bind2_N. IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR003952. FRD_SDH_FAD_BS. IPR004112. Fum_Rdtase/Succ_DH_flav_C. IPR005884. Fum_red_fp. IPR014006. Succ_Dhase_frdA_Gneg. [Graphical view]
Pfam	PF00890. FAD_binding_2. 1 hit. PF02910. Succ_DH_flav_C. 1 hit. [Graphical view]
PRINTS	PR00368. FADPNR.
TIGRFAMs	TIGR01176. fum_red_Fp. 1 hit. TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITE	PS00504. FRD_SDH_FAD_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FRDA_HAEIN

Accession

Primary (citable) accession number: P44894

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	June 16, 2009
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)