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P44894 (FRDA_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Fumarate reductase flavoprotein subunit
EC=1.3.99.1
Gene names
Name:frdA
Ordered Locus Names:HI_0835
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length599 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Succinate + acceptor = fumarate + reduced acceptor.

Cofactor

Binds 1 FAD covalently per subunit By similarity.

Subunit structure

Fumarate dehydrogenase forms part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, and two hydrophobic anchor proteins By similarity.

Sequence similarities

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 599599Fumarate reductase flavoprotein subunit
PRO_0000158661

Regions

Nucleotide binding9 – 2315FAD Potential

Sites

Active site2331 By similarity
Active site2491 By similarity

Amino acid modifications

Modified residue451Tele-8alpha-FAD histidine By similarity

Sequences

Sequence LengthMass (Da)Tools
P44894 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 30D4D3B10059236F

FASTA59965,933
        10         20         30         40         50         60 
MQTVNVDIAI VGAGGGGLRA AIAAAEANPN LKIALVSKVY PMRTHTVAAE GGAAAVIKEE 

        70         80         90        100        110        120 
DSYDKHFQDT VAGGDWLCEQ DVVEYFVQHS PVEMTQLERW GCPWSRKADG DVNVRRFGGM 

       130        140        150        160        170        180 
KIERTWFAAD KTGFHLLHTL FQTSIQYPQI QRFDEHFVLD ILVDDGHARG MVAMNMMEGS 

       190        200        210        220        230        240 
LVQINANAVV IATGGGCRAF KFNTNGGIVT GDGLSMAYRH GVPLRDMEFV QYHPTGLPNT 

       250        260        270        280        290        300 
GILMTEGCRG EGGILVNKDG YRYLQDYGLG PETPIGKPQN KYMELGPRDK VSQAFWQEWK 

       310        320        330        340        350        360 
KGNTLKTAKG VDVVHLDLRH LGEKYLHERL PFICELASAY EGVNPVNEPI PVRPVVHYTM 

       370        380        390        400        410        420 
GGIEVDFNSE TRIKGLFAVG ECASSGLHGA NRLGSNSLAE LVVLGRVAGE YAAQRAVEAQ 

       430        440        450        460        470        480 
SVNQSAVDAQ AKDVVARLEA LHKQEGNESW SEIRDEMGTV MEEGCGIYRD QASMQKAVDK 

       490        500        510        520        530        540 
IAELKERYKR IRVSDNSSVF NTDVLYTVEL GYILDVAQSI ANSAIERKES RGAHQRLDYT 

       550        560        570        580        590 
ERDDVNYLKH TLAFYNENGA PRIEYSPVKI TKSQPAKRVY GAEAEAQEAA AKAKEQANG

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L42023 Genomic DNA. Translation: AAC22493.1.
PIRH64097.
RefSeqNP_438995.1. NC_000907.1.

3D structure databases

ProteinModelPortalP44894.
SMRP44894. Positions 1-571.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID949849.
GenomeReviewsGene locus HI_0835 in contig L42023_GR.
KEGGhin:HI0835.
NMPDRfig|71421.1.peg.803.
PATRIC20190325. VBIHaeInf48452_0876.
TIGRHI_0835.

Phylogenomic databases

HOGENOMHBG293998.
OMARFDEYFV.
PhylomeDBP44894.
ProtClustDBPRK09231.

Enzyme and pathway databases

BioCycHINF71421:HI_0835-MONOMER.

Family and domain databases

InterProIPR003953. FAD_bind2_N.
IPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR004112. Fum_Rdtase/Succ_DH_flav_C.
IPR005884. Fum_red_fp.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
Gene3DG3DSA:1.20.58.100. Fum_Rdtase/Succ_DH_flav-like_C. 1 hit.
KOK00244.
PANTHERPTHR11632:SF5. PTHR11632:SF5. 1 hit.
PfamPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
PRINTSPR00368. FADPNR.
SUPFAMSSF46977. Succ_DH_flav_C. 1 hit.
TIGRFAMsTIGR01176. Fum_red_Fp. 1 hit.
TIGR01812. SdhA_frdA_Gneg. 1 hit.
PROSITEPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFRDA_HAEIN
AccessionPrimary (citable) accession number: P44894
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 25, 2012
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names

SIMILARITY comments

Index of protein domains and families

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