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P44893

- FRDB_HAEIN

UniProt

P44893 - FRDB_HAEIN

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Protein
Fumarate reductase iron-sulfur subunit
Gene
frdB, HI_0834
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.

Cofactori

Binds 1 2Fe-2S cluster By similarity.
Binds 1 3Fe-4S cluster By similarity.
Binds 1 4Fe-4S cluster By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi58 – 581Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi63 – 631Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi66 – 661Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi78 – 781Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi160 – 1601Iron-sulfur 2 (4Fe-4S) By similarity
Metal bindingi163 – 1631Iron-sulfur 2 (4Fe-4S) By similarity
Metal bindingi166 – 1661Iron-sulfur 2 (4Fe-4S) By similarity
Metal bindingi170 – 1701Iron-sulfur 3 (3Fe-4S) By similarity
Metal bindingi216 – 2161Iron-sulfur 3 (3Fe-4S) By similarity
Metal bindingi222 – 2221Iron-sulfur 3 (3Fe-4S) By similarity
Metal bindingi226 – 2261Iron-sulfur 2 (4Fe-4S) By similarity

GO - Molecular functioni

  1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
  2. 3 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  3. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  4. electron carrier activity Source: InterPro
  5. metal ion binding Source: UniProtKB-KW
  6. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

GO - Biological processi

  1. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport, Tricarboxylic acid cycle

Keywords - Ligandi

2Fe-2S, 3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fumarate reductase iron-sulfur subunit (EC:1.3.5.1)
Gene namesi
Name:frdB
Ordered Locus Names:HI_0834
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 256256Fumarate reductase iron-sulfur subunit
PRO_0000158702Add
BLAST

Interactioni

Subunit structurei

Fumarate dehydrogenase forms part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, and two hydrophobic anchor proteins By similarity.

Protein-protein interaction databases

STRINGi71421.HI0834.

Structurei

3D structure databases

ProteinModelPortaliP44893.
SMRiP44893. Positions 7-255.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 97912Fe-2S ferredoxin-type
Add
BLAST
Domaini151 – 180304Fe-4S ferredoxin-type
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0479.
KOiK00245.
OMAiCHFAASC.
OrthoDBiEOG6CK7MG.
PhylomeDBiP44893.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamiPF13085. Fer2_3. 1 hit.
PF13183. Fer4_8. 1 hit.
[Graphical view]
SUPFAMiSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR00384. dhsB. 1 hit.
PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P44893-1 [UniParc]FASTAAdd to Basket

« Hide

MANSPVMNVE VLRYNPEIDQ EPHLSTYQVP YDNQTSLLDA LGYIKDKLEP    50
SLSYRWSCRM AICGSCGMMV NNKPKLACKT FLRDYSGHMR IEPLANFPIE 100
RDLVVDLSHF IESLEAIKPY IIGNEAPALD GKPHPSKELQ VSRTKQTPAQ 150
LEKYRQFSMC INCGLCYAAC PQFGLNPEFL GPAAITMAHR YNLDNRDHGK 200
AKRMSLLNGK NGVWSCTFVG YCSEVCPKHV DPASAINQGK VESAKDYVIS 250
MLKPKG 256
Length:256
Mass (Da):28,668
Last modified:November 1, 1995 - v1
Checksum:i42E3851D0B6B355E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22492.1.
RefSeqiNP_438994.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22492; AAC22492; HI_0834.
GeneIDi949848.
KEGGihin:HI0834.
PATRICi20190323. VBIHaeInf48452_0875.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22492.1 .
RefSeqi NP_438994.1. NC_000907.1.

3D structure databases

ProteinModelPortali P44893.
SMRi P44893. Positions 7-255.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0834.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC22492 ; AAC22492 ; HI_0834 .
GeneIDi 949848.
KEGGi hin:HI0834.
PATRICi 20190323. VBIHaeInf48452_0875.

Phylogenomic databases

eggNOGi COG0479.
KOi K00245.
OMAi CHFAASC.
OrthoDBi EOG6CK7MG.
PhylomeDBi P44893.

Family and domain databases

Gene3Di 3.10.20.30. 1 hit.
InterProi IPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view ]
Pfami PF13085. Fer2_3. 1 hit.
PF13183. Fer4_8. 1 hit.
[Graphical view ]
SUPFAMi SSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsi TIGR00384. dhsB. 1 hit.
PROSITEi PS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiFRDB_HAEIN
AccessioniPrimary (citable) accession number: P44893
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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