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P44893 (FRDB_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fumarate reductase iron-sulfur subunit

EC=1.3.5.1
Gene names
Name:frdB
Ordered Locus Names:HI_0834
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length256 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Succinate + a quinone = fumarate + a quinol.

Cofactor

Binds 1 2Fe-2S cluster By similarity.

Binds 1 3Fe-4S cluster By similarity.

Binds 1 4Fe-4S cluster By similarity.

Subunit structure

Fumarate dehydrogenase forms part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, and two hydrophobic anchor proteins By similarity.

Sequence similarities

Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

Contains 1 2Fe-2S ferredoxin-type domain.

Contains 1 4Fe-4S ferredoxin-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 256256Fumarate reductase iron-sulfur subunit
PRO_0000158702

Regions

Domain7 – 97912Fe-2S ferredoxin-type
Domain151 – 180304Fe-4S ferredoxin-type

Sites

Metal binding581Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding631Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding661Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding781Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding1601Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1631Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1661Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1701Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2161Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2221Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2261Iron-sulfur 2 (4Fe-4S) By similarity

Sequences

Sequence LengthMass (Da)Tools
P44893 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 42E3851D0B6B355E

FASTA25628,668
        10         20         30         40         50         60 
MANSPVMNVE VLRYNPEIDQ EPHLSTYQVP YDNQTSLLDA LGYIKDKLEP SLSYRWSCRM 

        70         80         90        100        110        120 
AICGSCGMMV NNKPKLACKT FLRDYSGHMR IEPLANFPIE RDLVVDLSHF IESLEAIKPY 

       130        140        150        160        170        180 
IIGNEAPALD GKPHPSKELQ VSRTKQTPAQ LEKYRQFSMC INCGLCYAAC PQFGLNPEFL 

       190        200        210        220        230        240 
GPAAITMAHR YNLDNRDHGK AKRMSLLNGK NGVWSCTFVG YCSEVCPKHV DPASAINQGK 

       250 
VESAKDYVIS MLKPKG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC22492.1.
RefSeqNP_438994.1. NC_000907.1.

3D structure databases

ProteinModelPortalP44893.
SMRP44893. Positions 7-255.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI0834.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC22492; AAC22492; HI_0834.
GeneID949848.
KEGGhin:HI0834.
PATRIC20190323. VBIHaeInf48452_0875.

Phylogenomic databases

eggNOGCOG0479.
KOK00245.
OMACHFAASC.
OrthoDBEOG6CK7MG.
PhylomeDBP44893.

Family and domain databases

Gene3D3.10.20.30. 1 hit.
InterProIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamPF13085. Fer2_3. 1 hit.
PF13183. Fer4_8. 1 hit.
[Graphical view]
SUPFAMSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsTIGR00384. dhsB. 1 hit.
PROSITEPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFRDB_HAEIN
AccessionPrimary (citable) accession number: P44893
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names