P44881 (AMPP_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Xaa-Pro aminopeptidase
EC=3.4.11.9

Alternative name(s):
Aminoacylproline aminopeptidase
Aminopeptidase P II
Short name=APP-II
X-Pro aminopeptidase

Gene names

Name:	pepP
Ordered Locus Names:	HI_0816

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]

Taxonomic identifier

71421 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus › Haemophilus influenzae

Protein attributes

Sequence length	430 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the peptidase M24B family.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Aminopeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: InterPro metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 430	430	Xaa-Pro aminopeptidase		PRO_0000185076
Sites
	Metal binding	254	1	Manganese 2 By similarity
	Metal binding	265	1	Manganese 1 By similarity
	Metal binding	265	1	Manganese 2 By similarity
	Metal binding	348	1	Manganese 1 By similarity
	Metal binding	377	1	Manganese 1 By similarity
	Metal binding	400	1	Manganese 1 By similarity
	Metal binding	400	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	P44881 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 970C2CFFCB1FE2E6	FASTA	430	49,261
	10 20 30 40 50 60 MELAYMAKLP KEEFEERRTR VFAQMQPNSA LLLFSEIEKR RNNDCTYPFR QDSYFWYLTG 70 80 90 100 110 120 FNEPNAALLL LKTEQVEKAI IFLRPRDPLL ETWNGRRLGV ERAPQQLNVN EAYSIEEFAT 130 140 150 160 170 180 VLPKILKNLT ALYHVPEIHT WGDTLVSESA VNFSEILDWR PMLSEMRLIK SPNEIRLMQQ 190 200 210 220 230 240 AGQITALGHI KAMQTTRPNR FEYEIESDIL HEFNRHCARF PSYNSIVAGG SNACILHYTE 250 260 270 280 290 300 NDRPLNDGDL VLIDAGCEFA MYAGDITRTF PVNGKFSQPQ REIYELVLKA QKRAIELLVP 310 320 330 340 350 360 GNSIKQANDE VIRIKTQGLV DLGILKGDVD TLIEQQAYRQ FYMHGLGHWL GLDVHDVGSY 370 380 390 400 410 420 GQDKQRILEI GMVITVEPGI YISEDADVPE QYKGIGVRIE DNLLMTEYGN KILTAAVPKE 430 IADIENLMNF

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L42023 Genomic DNA. Translation: AAC22475.1.
PIR	B64096.
RefSeq	NP_438976.1. NC_000907.1.
3D structure databases
ProteinModelPortal	P44881.
SMR	P44881. Positions 7-429.
ModBase	Search...
Protein-protein interaction databases
STRING	71421.HI0816.
Protein family/group databases
MEROPS	M24.004.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC22475; AAC22475; HI_0816.
GeneID	949828.
KEGG	hin:HI0816.
PATRIC	20190287. VBIHaeInf48452_0857.
Phylogenomic databases
eggNOG	COG0006.
KO	K01262.
OMA	ASGAHAC.
ProtClustDB	CLSK870588.
Family and domain databases
Gene3D	3.90.230.10. 1 hit.
InterPro	IPR007865. Aminopep_P_N. IPR000994. Pept_M24_structural-domain. IPR001131. Peptidase_M24B_aminopep-P_CS. [Graphical view]
Pfam	PF05195. AMP_N. 1 hit. PF00557. Peptidase_M24. 1 hit. [Graphical view]
SMART	SM01011. AMP_N. 1 hit. [Graphical view]
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
PROSITE	PS00491. PROLINE_PEPTIDASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPP_HAEIN

Accession

Primary (citable) accession number: P44881

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	May 1, 2013
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program