P44877 (HSLO_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
33 kDa chaperonin

Alternative name(s):
Heat shock protein 33 homolog
Short name=HSP33

Gene names

Name:	hslO
Ordered Locus Names:	HI_0810

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]

Taxonomic identifier

71421 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus › Haemophilus influenzae

Protein attributes

Sequence length	293 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress By similarity. HAMAP-Rule MF_00117
Subcellular location	Cytoplasm By similarity.
Post-translational modification	Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive By similarity. HAMAP-Rule MF_00117
Sequence similarities	Belongs to the HSP33 family.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	Redox-active center
Ligand	Zinc
Molecular function	Chaperone
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein folding Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 293	293	33 kDa chaperonin HAMAP-Rule MF_00117		PRO_0000192180
Amino acid modifications
	Disulfide bond	237 ↔ 239		Redox-active By similarity
	Disulfide bond	271 ↔ 274		Redox-active By similarity

Sequences

	Sequence		Length	Mass (Da)
	P44877 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 05C25281B6CCE96A	FASTA	293	33,103
	10 20 30 40 50 60 MTNQQDYTQD NDKLYRYLFQ HRAVRGEWVR LNKTFTDTLN THQYPKAVQD LLGEMMVATN 70 80 90 100 110 120 LLTATLKFAG NITVQIQGDG PLRLALVNGN DQQQIRALAR VDGNITENMS LHNMIGKGVL 130 140 150 160 170 180 VITIAPKEGE RYQGVISLDK PTITECLEDY FVRSEQLQTQ LIIRTGEYEG KPVAAGMLLQ 190 200 210 220 230 240 IMPDGSGTPE DFEHLTTLAA TVKDEELFGL PAEELLYRLY HEETVNLYPA QDVQFFCGCS 250 260 270 280 290 AERSSSALLL ISDEEIDEIL AEHKGRIDMQ CECCGTHYFF NKEAIEKLKS TRV

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L42023 Genomic DNA. Translation: AAC22469.1.
PIR	H64158.
RefSeq	NP_438970.1. NC_000907.1.
3D structure databases
ProteinModelPortal	P44877.
SMR	P44877. Positions 11-239.
ModBase	Search...
Protein-protein interaction databases
STRING	71421.HI0810.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC22469; AAC22469; HI_0810.
GeneID	950307.
KEGG	hin:HI0810.
PATRIC	20190275. VBIHaeInf48452_0851.
Phylogenomic databases
eggNOG	COG1281.
KO	K04083.
OMA	DMQCECC.
ProtClustDB	PRK00114.
Family and domain databases
Gene3D	1.10.287.480. 1 hit. 3.55.30.10. 1 hit. 3.90.1280.10. 1 hit.
HAMAP	MF_00117. HslO.
InterPro	IPR000397. Heat_shock_Hsp33. IPR016154. Heat_shock_Hsp33_C. IPR016153. Heat_shock_Hsp33_N. IPR023212. Hsp33_helix_hairpin_bin_dom. [Graphical view]
Pfam	PF01430. HSP33. 1 hit. [Graphical view]
PIRSF	PIRSF005261. Heat_shock_Hsp33. 1 hit.
SUPFAM	SSF64397. Heat_shock_Hsp33_N. 1 hit. SSF118352. SSF118352. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HSLO_HAEIN

Accession

Primary (citable) accession number: P44877

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	May 1, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program