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P44873 (ATOB_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acetyl-CoA acetyltransferase
EC=2.3.1.9
Alternative name(s):
Acetoacetyl-CoA thiolase
Gene names
Name:atoB
Synonyms:thi, thl
Ordered Locus Names:HI_0771
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length393 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2 acetyl-CoA = CoA + acetoacetyl-CoA.

Pathway

Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 1/3.

Subcellular location

Cytoplasm Potential.

Sequence similarities

Belongs to the thiolase family.

Ontologies

Keywords
   Biological processFatty acid metabolism
Lipid metabolism
   Cellular componentCytoplasm
   Molecular functionAcyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processfatty acid metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionacetyl-CoA C-acetyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 393393Acetyl-CoA acetyltransferase
PRO_0000206407

Sites

Active site881Acyl-thioester intermediate By similarity
Active site3491Proton acceptor By similarity
Active site3791Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
P44873 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 1C1FB6D1AE4D8410

FASTA39340,801
        10         20         30         40         50         60 
MENVVIVSAV RTPIGSFNGA LSSVSAVDLG AIVIQEAIKR ANIESALVNE VIMGNVLQAG 

        70         80         90        100        110        120 
LGQNPARQAA LKAGIEKEIP SLTINKVCGS GLKSVALGAQ SIISGDADIV VVGGMENMSQ 

       130        140        150        160        170        180 
APYLLDSKVR QGVKMGNLTL RDTMIEDGLT CASNHYHMGI TAENIAEQYG ISRQAQDELA 

       190        200        210        220        230        240 
LRSQTLASQA VQLGVFDKEI VPVMVKTRKG DIIVSRDEYP KADTTAEGLA KLKPAFKKEG 

       250        260        270        280        290        300 
TVTAGNASGI NDGAAALILV SESKAHALGL KAIAKIRSYA SGGVDPSVMG LGPVPATQKA 

       310        320        330        340        350        360 
LKKAGINLDD IDLIEANEAF ASQFLGVGKD LNLDMNKTNI HGGAIALGHP IGASGARILV 

       370        380        390 
TLLHNLIEKD KKLGLATLCI GGGQGISMIV ERL

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L42023 Genomic DNA. Translation: AAC22430.1.
RefSeqNP_438930.1. NC_000907.1.

3D structure databases

ProteinModelPortalP44873.
SMRP44873. Positions 3-393.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID950638.
GenomeReviewsGene locus HI_0771 in contig L42023_GR.
KEGGhin:HI0771.
PATRIC20190193. VBIHaeInf48452_0810.
TIGRHI_0771.

Phylogenomic databases

HOGENOMHBG370930.
OMAVGAREMG.
PhylomeDBP44873.
ProtClustDBCLSK891768.

Enzyme and pathway databases

BioCycHINF71421:HI_0771-MONOMER.

Family and domain databases

InterProIPR002155. Thiolase.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
IPR020615. Thiolase_acyl_enz_int_AS.
IPR020610. Thiolase_AS.
IPR020617. Thiolase_C.
IPR020613. Thiolase_CS.
IPR020616. Thiolase_N.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 4 hits.
KOK00626.
PANTHERPTHR18919. Thiolase. 1 hit.
PfamPF02803. Thiolase_C. 1 hit.
PF00108. Thiolase_N. 1 hit.
[Graphical view]
PIRSFPIRSF000429. Ac-CoA_Ac_transf. 1 hit.
SUPFAMSSF53901. Thiolase-like. 2 hits.
TIGRFAMsTIGR01930. AcCoA-C-Actrans. 1 hit.
PROSITEPS00098. THIOLASE_1. 1 hit.
PS00737. THIOLASE_2. 1 hit.
PS00099. THIOLASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameATOB_HAEIN
AccessionPrimary (citable) accession number: P44873
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 25, 2012
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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