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P44861

- ANMK_HAEIN

UniProt

P44861 - ANMK_HAEIN

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Protein
Anhydro-N-acetylmuramic acid kinase
Gene
anmK, HI_0753
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling By similarity.UniRule annotation

Catalytic activityi

ATP + 1,6-anhydro-N-acetyl-beta-muramate + H2O = ADP + N-acetylmuramate 6-phosphate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 228ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. kinase activity Source: UniProtKB-KW
  3. phosphotransferase activity, alcohol group as acceptor Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 1,6-anhydro-N-acetyl-beta-muramic acid catabolic process Source: UniProtKB-UniPathway
  2. amino sugar metabolic process Source: UniProtKB-HAMAP
  3. carbohydrate metabolic process Source: UniProtKB-KW
  4. peptidoglycan turnover Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00343.
UPA00544.

Names & Taxonomyi

Protein namesi
Recommended name:
Anhydro-N-acetylmuramic acid kinase (EC:2.7.1.170)
Alternative name(s):
AnhMurNAc kinase
Gene namesi
Name:anmK
Ordered Locus Names:HI_0753
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 382382Anhydro-N-acetylmuramic acid kinaseUniRule annotation
PRO_0000214822Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0753.

Structurei

3D structure databases

ProteinModelPortaliP44861.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2377.
KOiK09001.
OMAiGRYIGVM.
OrthoDBiEOG64N9WW.
PhylomeDBiP44861.

Family and domain databases

HAMAPiMF_01270. AnhMurNAc_kinase.
InterProiIPR005338. Anhydro_N_Ac-Mur_kinase.
[Graphical view]
PfamiPF03702. UPF0075. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P44861-1 [UniParc]FASTAAdd to Basket

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MINMKPQYYL GMMSGTSLDG VDIVLVDFSQ DPQLILSDFF PMPEDLREKL    50
TTLIQVGETT LQNLGELDHK LALLYSDCVN AFLQKNTFLP NQIQAIGCHG 100
QTVWHSPNSQ FPFTMQLGDM NLLAAKTGIS VIGDFRRKDM AWGGQGAPLV 150
PAFHEAVFSN SNFATAVLNI GGISNVSILF PNQAVIGFDT GPGNTLLDQW 200
IEKHQGLRYD ENGEWAAKGN VNKVLLDELL NEPFFSLPAP KSTGRELFNL 250
VWLNHKIAKI REKLTALSVE MSFRPEDVQA TLVELTVTSI VNALNQLQTD 300
LPKRLLVCGG GAKNSLIMRG LHDNLLDWQV STTTEQGFDI DYVEAAAFAW 350
LAYCRINNLP ANLPSVTGAK SAVSLGAIFP KD 382
Length:382
Mass (Da):42,026
Last modified:November 1, 1995 - v1
Checksum:iD14E353287BC11A6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22412.1.
PIRiB64158.
RefSeqiNP_438912.1. NC_000907.1.
WP_005693152.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22412; AAC22412; HI_0753.
GeneIDi949467.
KEGGihin:HI0753.
PATRICi20190151. VBIHaeInf48452_0791.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22412.1 .
PIRi B64158.
RefSeqi NP_438912.1. NC_000907.1.
WP_005693152.1. NC_000907.1.

3D structure databases

ProteinModelPortali P44861.
ModBasei Search...

Protein-protein interaction databases

STRINGi 71421.HI0753.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC22412 ; AAC22412 ; HI_0753 .
GeneIDi 949467.
KEGGi hin:HI0753.
PATRICi 20190151. VBIHaeInf48452_0791.

Phylogenomic databases

eggNOGi COG2377.
KOi K09001.
OMAi GRYIGVM.
OrthoDBi EOG64N9WW.
PhylomeDBi P44861.

Enzyme and pathway databases

UniPathwayi UPA00343 .
UPA00544 .

Family and domain databases

HAMAPi MF_01270. AnhMurNAc_kinase.
InterProi IPR005338. Anhydro_N_Ac-Mur_kinase.
[Graphical view ]
Pfami PF03702. UPF0075. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiANMK_HAEIN
AccessioniPrimary (citable) accession number: P44861
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 3, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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