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P44861

- ANMK_HAEIN

UniProt

P44861 - ANMK_HAEIN

Protein

Anhydro-N-acetylmuramic acid kinase

Gene

anmK

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.UniRule annotation

    Catalytic activityi

    ATP + 1,6-anhydro-N-acetyl-beta-muramate + H2O = ADP + N-acetylmuramate 6-phosphate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi15 – 228ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. kinase activity Source: UniProtKB-KW
    3. phosphotransferase activity, alcohol group as acceptor Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 1,6-anhydro-N-acetyl-beta-muramic acid catabolic process Source: UniProtKB-UniPathway
    2. amino sugar metabolic process Source: UniProtKB-HAMAP
    3. carbohydrate metabolic process Source: UniProtKB-KW
    4. peptidoglycan turnover Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Carbohydrate metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00343.
    UPA00544.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Anhydro-N-acetylmuramic acid kinaseUniRule annotation (EC:2.7.1.170UniRule annotation)
    Alternative name(s):
    AnhMurNAc kinaseUniRule annotation
    Gene namesi
    Name:anmKUniRule annotation
    Ordered Locus Names:HI_0753
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 382382Anhydro-N-acetylmuramic acid kinasePRO_0000214822Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi71421.HI0753.

    Structurei

    3D structure databases

    ProteinModelPortaliP44861.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the anhydro-N-acetylmuramic acid kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2377.
    KOiK09001.
    OMAiGRYIGVM.
    OrthoDBiEOG64N9WW.
    PhylomeDBiP44861.

    Family and domain databases

    HAMAPiMF_01270. AnhMurNAc_kinase.
    InterProiIPR005338. Anhydro_N_Ac-Mur_kinase.
    [Graphical view]
    PfamiPF03702. UPF0075. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P44861-1 [UniParc]FASTAAdd to Basket

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    MINMKPQYYL GMMSGTSLDG VDIVLVDFSQ DPQLILSDFF PMPEDLREKL    50
    TTLIQVGETT LQNLGELDHK LALLYSDCVN AFLQKNTFLP NQIQAIGCHG 100
    QTVWHSPNSQ FPFTMQLGDM NLLAAKTGIS VIGDFRRKDM AWGGQGAPLV 150
    PAFHEAVFSN SNFATAVLNI GGISNVSILF PNQAVIGFDT GPGNTLLDQW 200
    IEKHQGLRYD ENGEWAAKGN VNKVLLDELL NEPFFSLPAP KSTGRELFNL 250
    VWLNHKIAKI REKLTALSVE MSFRPEDVQA TLVELTVTSI VNALNQLQTD 300
    LPKRLLVCGG GAKNSLIMRG LHDNLLDWQV STTTEQGFDI DYVEAAAFAW 350
    LAYCRINNLP ANLPSVTGAK SAVSLGAIFP KD 382
    Length:382
    Mass (Da):42,026
    Last modified:November 1, 1995 - v1
    Checksum:iD14E353287BC11A6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22412.1.
    PIRiB64158.
    RefSeqiNP_438912.1. NC_000907.1.
    WP_005693152.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC22412; AAC22412; HI_0753.
    GeneIDi949467.
    KEGGihin:HI0753.
    PATRICi20190151. VBIHaeInf48452_0791.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22412.1 .
    PIRi B64158.
    RefSeqi NP_438912.1. NC_000907.1.
    WP_005693152.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P44861.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI0753.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC22412 ; AAC22412 ; HI_0753 .
    GeneIDi 949467.
    KEGGi hin:HI0753.
    PATRICi 20190151. VBIHaeInf48452_0791.

    Phylogenomic databases

    eggNOGi COG2377.
    KOi K09001.
    OMAi GRYIGVM.
    OrthoDBi EOG64N9WW.
    PhylomeDBi P44861.

    Enzyme and pathway databases

    UniPathwayi UPA00343 .
    UPA00544 .

    Family and domain databases

    HAMAPi MF_01270. AnhMurNAc_kinase.
    InterProi IPR005338. Anhydro_N_Ac-Mur_kinase.
    [Graphical view ]
    Pfami PF03702. UPF0075. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiANMK_HAEIN
    AccessioniPrimary (citable) accession number: P44861
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3