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Protein

Anhydro-N-acetylmuramic acid kinase

Gene

anmK

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.UniRule annotation

Catalytic activityi

ATP + 1,6-anhydro-N-acetyl-beta-muramate + H2O = ADP + N-acetylmuramate 6-phosphate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 228ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. kinase activity Source: UniProtKB-KW
  3. phosphotransferase activity, alcohol group as acceptor Source: UniProtKB-HAMAP

GO - Biological processi

  1. 1,6-anhydro-N-acetyl-beta-muramic acid catabolic process Source: UniProtKB-UniPathway
  2. amino sugar metabolic process Source: UniProtKB-HAMAP
  3. carbohydrate metabolic process Source: UniProtKB-KW
  4. peptidoglycan turnover Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00343.
UPA00544.

Names & Taxonomyi

Protein namesi
Recommended name:
Anhydro-N-acetylmuramic acid kinaseUniRule annotation (EC:2.7.1.170UniRule annotation)
Alternative name(s):
AnhMurNAc kinaseUniRule annotation
Gene namesi
Name:anmKUniRule annotation
Ordered Locus Names:HI_0753
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 382382Anhydro-N-acetylmuramic acid kinasePRO_0000214822Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0753.

Structurei

3D structure databases

ProteinModelPortaliP44861.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the anhydro-N-acetylmuramic acid kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2377.
KOiK09001.
OMAiFRRKDMA.
OrthoDBiEOG64N9WW.
PhylomeDBiP44861.

Family and domain databases

HAMAPiMF_01270. AnhMurNAc_kinase.
InterProiIPR005338. Anhydro_N_Ac-Mur_kinase.
[Graphical view]
PfamiPF03702. UPF0075. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P44861-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MINMKPQYYL GMMSGTSLDG VDIVLVDFSQ DPQLILSDFF PMPEDLREKL
60 70 80 90 100
TTLIQVGETT LQNLGELDHK LALLYSDCVN AFLQKNTFLP NQIQAIGCHG
110 120 130 140 150
QTVWHSPNSQ FPFTMQLGDM NLLAAKTGIS VIGDFRRKDM AWGGQGAPLV
160 170 180 190 200
PAFHEAVFSN SNFATAVLNI GGISNVSILF PNQAVIGFDT GPGNTLLDQW
210 220 230 240 250
IEKHQGLRYD ENGEWAAKGN VNKVLLDELL NEPFFSLPAP KSTGRELFNL
260 270 280 290 300
VWLNHKIAKI REKLTALSVE MSFRPEDVQA TLVELTVTSI VNALNQLQTD
310 320 330 340 350
LPKRLLVCGG GAKNSLIMRG LHDNLLDWQV STTTEQGFDI DYVEAAAFAW
360 370 380
LAYCRINNLP ANLPSVTGAK SAVSLGAIFP KD
Length:382
Mass (Da):42,026
Last modified:November 1, 1995 - v1
Checksum:iD14E353287BC11A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22412.1.
PIRiB64158.
RefSeqiNP_438912.1. NC_000907.1.
WP_005693152.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22412; AAC22412; HI_0753.
GeneIDi949467.
KEGGihin:HI0753.
PATRICi20190151. VBIHaeInf48452_0791.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22412.1.
PIRiB64158.
RefSeqiNP_438912.1. NC_000907.1.
WP_005693152.1. NC_000907.1.

3D structure databases

ProteinModelPortaliP44861.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI0753.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC22412; AAC22412; HI_0753.
GeneIDi949467.
KEGGihin:HI0753.
PATRICi20190151. VBIHaeInf48452_0791.

Phylogenomic databases

eggNOGiCOG2377.
KOiK09001.
OMAiFRRKDMA.
OrthoDBiEOG64N9WW.
PhylomeDBiP44861.

Enzyme and pathway databases

UniPathwayiUPA00343.
UPA00544.

Family and domain databases

HAMAPiMF_01270. AnhMurNAc_kinase.
InterProiIPR005338. Anhydro_N_Ac-Mur_kinase.
[Graphical view]
PfamiPF03702. UPF0075. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiANMK_HAEIN
AccessioniPrimary (citable) accession number: P44861
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 7, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.