P44861 (ANMK_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Anhydro-N-acetylmuramic acid kinase
EC=2.7.1.170

Alternative name(s):
AnhMurNAc kinase

Gene names

Name:	anmK
Ordered Locus Names:	HI_0753

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]

Taxonomic identifier

71421 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus › Haemophilus influenzae

Protein attributes

Sequence length	382 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling By similarity. HAMAP-Rule MF_01270
Catalytic activity	ATP + 1,6-anhydro-N-acetyl-beta-muramate + H2O = ADP + N-acetylmuramate 6-phosphate. HAMAP-Rule MF_01270
Pathway	Amino-sugar metabolism; 1,6-anhydro-N-acetylmuramate degradation. HAMAP-Rule MF_01270 Cell wall biogenesis; peptidoglycan recycling. HAMAP-Rule MF_01270
Sequence similarities	Belongs to the anhydro-N-acetylmuramic acid kinase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	1,6-anhydro-N-acetyl-beta-muramic acid catabolic process Inferred from electronic annotation. Source: UniProtKB-UniPathway amino sugar metabolic process Inferred from electronic annotation. Source: HAMAP carbohydrate metabolic process Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan turnover Inferred from electronic annotation. Source: HAMAP
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP kinase activity Inferred from electronic annotation. Source: UniProtKB-KW phosphotransferase activity, alcohol group as acceptor Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 382	382	Anhydro-N-acetylmuramic acid kinase HAMAP-Rule MF_01270		PRO_0000214822
Regions
	Nucleotide binding	15 – 22	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	P44861 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: D14E353287BC11A6	FASTA	382	42,026
	10 20 30 40 50 60 MINMKPQYYL GMMSGTSLDG VDIVLVDFSQ DPQLILSDFF PMPEDLREKL TTLIQVGETT 70 80 90 100 110 120 LQNLGELDHK LALLYSDCVN AFLQKNTFLP NQIQAIGCHG QTVWHSPNSQ FPFTMQLGDM 130 140 150 160 170 180 NLLAAKTGIS VIGDFRRKDM AWGGQGAPLV PAFHEAVFSN SNFATAVLNI GGISNVSILF 190 200 210 220 230 240 PNQAVIGFDT GPGNTLLDQW IEKHQGLRYD ENGEWAAKGN VNKVLLDELL NEPFFSLPAP 250 260 270 280 290 300 KSTGRELFNL VWLNHKIAKI REKLTALSVE MSFRPEDVQA TLVELTVTSI VNALNQLQTD 310 320 330 340 350 360 LPKRLLVCGG GAKNSLIMRG LHDNLLDWQV STTTEQGFDI DYVEAAAFAW LAYCRINNLP 370 380 ANLPSVTGAK SAVSLGAIFP KD

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L42023 Genomic DNA. Translation: AAC22412.1.
PIR	B64158.
RefSeq	NP_438912.1. NC_000907.1.
3D structure databases
ProteinModelPortal	P44861.
ModBase	Search...
Protein-protein interaction databases
STRING	71421.HI0753.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC22412; AAC22412; HI_0753.
GeneID	949467.
KEGG	hin:HI0753.
PATRIC	20190151. VBIHaeInf48452_0791.
Phylogenomic databases
eggNOG	COG2377.
KO	K09001.
OMA	YIGLMSG.
ProtClustDB	PRK09585.
Enzyme and pathway databases
UniPathway	UPA00343. UPA00544.
Family and domain databases
HAMAP	MF_01270. AnhMurNAc_kinase.
InterPro	IPR005338. Anhydro_N_Ac-Mur_kinase. [Graphical view]
Pfam	PF03702. UPF0075. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ANMK_HAEIN

Accession

Primary (citable) accession number: P44861

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	May 1, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program