Diaminopimelate epimerase - Haemophilus influenzae

Contribute

Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot P44859 (DAPF_HAEIN)

Last modified June 16, 2009. Version 66. History...

Clusters with 100%, 90%, 50% identity |

Documents (4) |

Third-party data |

Customize display

text xml rdf/xml gff fasta

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
    Diaminopimelate epimerase
      Short name=DAP epimerase
    EC=5.1.1.7

Gene names

Name:	dapF
Ordered Locus Names:	HI0750

Organism

Haemophilus influenzae [Complete proteome] [HAMAP]

Taxonomic identifier

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	274 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate. HAMAP MF_00197
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-diaminopimelate from LL-diaminopimelate: step 1/1. HAMAP MF_00197
Subunit structure	Monomer. HAMAP MF_00197
Subcellular location	Cytoplasm. HAMAP MF_00197
Sequence similarities	Belongs to the diaminopimelate epimerase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	lysine biosynthetic process via diaminopimelate Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	diaminopimelate epimerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

274

Diaminopimelate epimerase HAMAP MF_00197

PRO_0000149842

Sites

Active site

1

Active site

1

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

274

Helix Strand Turn

Sequences

Sequence

Length

Mass (Da)

Tools

P44859-1 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 321B3CDAFFE81EDA
Show »

274

30,249

        10         20         30         40         50         60 
MQFSKMHGLG NDFVVVDGVT QNVFFTPETI RRLANRHCGI GFDQLLIVEA PYDPELDFHY 

        70         80         90        100        110        120 
RIFNADGSEV SQCGNGARCF ARFVTLKGLT NKKDISVSTQ KGNMVLTVKD DNQIRVNMGE 

       130        140        150        160        170        180 
PIWEPAKIPF TANKFEKNYI LRTDIQTVLC GAVSMGNPHC VVQVDDIQTA NVEQLGPLLE 

       190        200        210        220        230        240 
SHERFPERVN AGFMQIINKE HIKLRVYERG AGETQACGSG ACAAVAVGIM QGLLNNNVQV 

       250        260        270 
DLPGGSLMIE WNGVGHPLYM TGEATHIYDG FITL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
[2]	"Structural symmetry: the three-dimensional structure of Haemophilus influenzae diaminopimelate epimerase." Cirilli M., Zheng R., Scapin G., Blanchard J.S. Biochemistry 37:16452-16458(1998) [PubMed: 9843410] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.72 ANGSTROMS).
+	Additional computationally mapped references.

Cross-references

Sequence databases

L42023 Genomic DNA. Translation: AAC22409.1.

PIR

RefSeq

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1BWZ	X-ray	2.72	A	1-274	[»]
1GQZ	X-ray	1.75	A	1-274	[»]
2GKE	X-ray	1.35	A	1-274	[»]
2GKJ	X-ray	1.70	A	1-274	[»]
2Q9H	X-ray	2.30	A	1-274	[»]
2Q9J	X-ray	2.20	A	1-274	[»]

ModBase

Genome annotation databases

GeneID

GenomeReviews

Gene locus HI0750 in contig L42023_GR.

KEGG

TIGR

Phylogenomic databases

HOGENOM

OMA

P44859. PHAVLRV.

Enzyme and pathway databases

BioCyc

HINF71421:HI_0750-MON.

BRENDA

5.1.1.7. 109.

Family and domain databases

HAMAP

MF_00197.
[Tree]

InterPro

IPR001653. DAP_epimerase.
IPR018510. DAP_epimerase_CS.
[Graphical view]

Pfam

PF01678. DAP_epimerase. 2 hits.
[Graphical view]

TIGRFAMs

TIGR00652. DapF. 1 hit.

PROSITE

PS01326. DAP_EPIMERASE. 1 hit.
[Graphical view]

ProtoNet

Entry information

Entry name

DAPF_HAEIN

Accession

Primary (citable) accession number: P44859

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	June 16, 2009
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents