Reviewed, UniProtKB/Swiss-Prot P44856 (DHNA_HAEIN)

Names and origin

Protein names

Recommended name:
    NADH dehydrogenase
    EC=1.6.99.3

Gene names

Name:	ndh
Ordered Locus Names:	HI0747

Organism

Haemophilus influenzae [Complete proteome] [HAMAP]

Taxonomic identifier

727 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	444 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Does not couple the redox reaction to proton translocation By similarity.
Catalytic activity	NADH + acceptor = NAD+ + reduced acceptor.
Cofactor	Binds 1 FAD per subunit By similarity.
Subcellular location	Cell membrane By similarity.
Sequence similarities	Belongs to the NADH dehydrogenase family.

Ontologies

Keywords
Biological process	Electron transport Transport
Cellular component	Cell membrane Membrane
Ligand	FAD Flavoprotein NAD Ubiquinone
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro NADH dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 444	444	NADH dehydrogenase		PRO_0000079891
Regions
	Nucleotide binding	3 – 38	36	FAD By similarity
	Nucleotide binding	181 – 218	38	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	P44856-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: B0EFE3613FE6B78B	FASTA	444	48,778
	10 20 30 40 50 60 MKNVVIVGGG AGGIELATFL GNKLGRQKQA KVTLVDRNAT HLWKPLLHEI ATGVMDDGVD 70 80 90 100 110 120 SLSYRAHGKN HFFSFEQGSI IRINREQKYV ELAPVYGQEG DMLVIARRIP YDYLVIAIGS 130 140 150 160 170 180 KSNDFNTKGV ADNCIFLDSS KQALRFQHKL LELFLKFSEN RALDDIGEEE FKQKLVDENK 190 200 210 220 230 240 VNIAIVGGGA TGVELTAELY HAAEDLSSYG YGKIDSSCLQ VTLVEAGTRL LPALPENLSA 250 260 270 280 290 300 AVLDELKEMG TNVQLNTMIT EAQPNTLITK DGGEIKADLI VWAAGVRAST VTQQFDGLEI 310 320 330 340 350 360 NRINQLVVKD TLQTTVDDSI FAIGDCAALI QSNGKLVPPR AQAAHQMAKA CAKNIFALFE 370 380 390 400 410 420 NKPLKSFKYN DKGTLVSLSN FTALGSLTNK FGKNPLTVQG KFAQFAYVSL YRMHQHALHG 430 440 CIKIGLIILV DKLNRYLKPR LKLH

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L42023 Genomic DNA. Translation: AAC22405.1.
PIR	C64090.
RefSeq	NP_438906.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	949772.
GenomeReviews	Gene locus HI0747 in contig L42023_GR.
KEGG	hin:HI0747.
TIGR	HI0747.
Phylogenomic databases
HOGENOM	HBG668030.
OMA	TNDFGTT.
Enzyme and pathway databases
BioCyc	HINF71421:HI_0747-MONOMER.
BRENDA	1.6.99.3. 109.
Family and domain databases
InterPro	IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR001327. Pyr_OxRdtase_NAD_bd. [Graphical view]
Pfam	PF00070. Pyr_redox. 2 hits. PF07992. Pyr_redox_2. 1 hit. [Graphical view]
PRINTS	PR00368. FADPNR.
ProtoNet	Search...

Entry information

Entry name

DHNA_HAEIN

Accession

Primary (citable) accession number: P44856

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	February 9, 2010
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)