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P44856 (DHNA_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH dehydrogenase

EC=1.6.99.3
Gene names
Name:ndh
Ordered Locus Names:HI_0747
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length444 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Does not couple the redox reaction to proton translocation By similarity.

Catalytic activity

NADH + acceptor = NAD+ + reduced acceptor.

Cofactor

Binds 1 FAD per subunit By similarity.

Subcellular location

Cell membrane By similarity.

Sequence similarities

Belongs to the NADH dehydrogenase family.

Ontologies

Keywords
   Biological processElectron transport
Transport
   Cellular componentCell membrane
Membrane
   LigandFAD
Flavoprotein
NAD
Ubiquinone
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentplasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionNADH dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-EC

flavin adenine dinucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 444444NADH dehydrogenase
PRO_0000079891

Regions

Nucleotide binding3 – 3836FAD By similarity
Nucleotide binding181 – 21838NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
P44856 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: B0EFE3613FE6B78B

FASTA44448,778
        10         20         30         40         50         60 
MKNVVIVGGG AGGIELATFL GNKLGRQKQA KVTLVDRNAT HLWKPLLHEI ATGVMDDGVD 

        70         80         90        100        110        120 
SLSYRAHGKN HFFSFEQGSI IRINREQKYV ELAPVYGQEG DMLVIARRIP YDYLVIAIGS 

       130        140        150        160        170        180 
KSNDFNTKGV ADNCIFLDSS KQALRFQHKL LELFLKFSEN RALDDIGEEE FKQKLVDENK 

       190        200        210        220        230        240 
VNIAIVGGGA TGVELTAELY HAAEDLSSYG YGKIDSSCLQ VTLVEAGTRL LPALPENLSA 

       250        260        270        280        290        300 
AVLDELKEMG TNVQLNTMIT EAQPNTLITK DGGEIKADLI VWAAGVRAST VTQQFDGLEI 

       310        320        330        340        350        360 
NRINQLVVKD TLQTTVDDSI FAIGDCAALI QSNGKLVPPR AQAAHQMAKA CAKNIFALFE 

       370        380        390        400        410        420 
NKPLKSFKYN DKGTLVSLSN FTALGSLTNK FGKNPLTVQG KFAQFAYVSL YRMHQHALHG 

       430        440 
CIKIGLIILV DKLNRYLKPR LKLH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC22405.1.
PIRC64090.
RefSeqNP_438906.1. NC_000907.1.

3D structure databases

ProteinModelPortalP44856.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI0747.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC22405; AAC22405; HI_0747.
GeneID949772.
KEGGhin:HI0747.
PATRIC20190137. VBIHaeInf48452_0784.

Phylogenomic databases

eggNOGCOG1252.
KOK03885.
OMASHKDVFV.
OrthoDBEOG6QZMR6.
PhylomeDBP44856.

Family and domain databases

InterProIPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR001327. Pyr_OxRdtase_NAD-bd_dom.
[Graphical view]
PfamPF00070. Pyr_redox. 2 hits.
PF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PRINTSPR00368. FADPNR.
ProtoNetSearch...

Entry information

Entry nameDHNA_HAEIN
AccessionPrimary (citable) accession number: P44856
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names