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Protein

NADH dehydrogenase

Gene

ndh

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Does not couple the redox reaction to proton translocation (By similarity).By similarity

Catalytic activityi

NADH + acceptor = NAD+ + reduced acceptor.

Cofactori

FADBy similarityNote: Binds 1 FAD per subunit.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi3 – 3836FADBy similarityAdd
BLAST
Nucleotide bindingi181 – 21838NADBy similarityAdd
BLAST

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: InterPro
  2. NADH dehydrogenase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

FAD, Flavoprotein, NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase (EC:1.6.99.3)
Gene namesi
Name:ndh
Ordered Locus Names:HI_0747
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

Subcellular locationi

Cell membrane By similarity

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 444444NADH dehydrogenasePRO_0000079891Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0747.

Structurei

3D structure databases

ProteinModelPortaliP44856.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NADH dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG1252.
KOiK03885.
OMAiRASEWRW.
OrthoDBiEOG6QZMR6.
PhylomeDBiP44856.

Family and domain databases

InterProiIPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR001327. Pyr_OxRdtase_NAD-bd_dom.
[Graphical view]
PfamiPF00070. Pyr_redox. 2 hits.
PF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PRINTSiPR00368. FADPNR.

Sequencei

Sequence statusi: Complete.

P44856-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNVVIVGGG AGGIELATFL GNKLGRQKQA KVTLVDRNAT HLWKPLLHEI
60 70 80 90 100
ATGVMDDGVD SLSYRAHGKN HFFSFEQGSI IRINREQKYV ELAPVYGQEG
110 120 130 140 150
DMLVIARRIP YDYLVIAIGS KSNDFNTKGV ADNCIFLDSS KQALRFQHKL
160 170 180 190 200
LELFLKFSEN RALDDIGEEE FKQKLVDENK VNIAIVGGGA TGVELTAELY
210 220 230 240 250
HAAEDLSSYG YGKIDSSCLQ VTLVEAGTRL LPALPENLSA AVLDELKEMG
260 270 280 290 300
TNVQLNTMIT EAQPNTLITK DGGEIKADLI VWAAGVRAST VTQQFDGLEI
310 320 330 340 350
NRINQLVVKD TLQTTVDDSI FAIGDCAALI QSNGKLVPPR AQAAHQMAKA
360 370 380 390 400
CAKNIFALFE NKPLKSFKYN DKGTLVSLSN FTALGSLTNK FGKNPLTVQG
410 420 430 440
KFAQFAYVSL YRMHQHALHG CIKIGLIILV DKLNRYLKPR LKLH
Length:444
Mass (Da):48,778
Last modified:November 1, 1995 - v1
Checksum:iB0EFE3613FE6B78B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22405.1.
PIRiC64090.
RefSeqiNP_438906.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22405; AAC22405; HI_0747.
GeneIDi949772.
KEGGihin:HI0747.
PATRICi20190137. VBIHaeInf48452_0784.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22405.1.
PIRiC64090.
RefSeqiNP_438906.1. NC_000907.1.

3D structure databases

ProteinModelPortaliP44856.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI0747.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC22405; AAC22405; HI_0747.
GeneIDi949772.
KEGGihin:HI0747.
PATRICi20190137. VBIHaeInf48452_0784.

Phylogenomic databases

eggNOGiCOG1252.
KOiK03885.
OMAiRASEWRW.
OrthoDBiEOG6QZMR6.
PhylomeDBiP44856.

Family and domain databases

InterProiIPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR001327. Pyr_OxRdtase_NAD-bd_dom.
[Graphical view]
PfamiPF00070. Pyr_redox. 2 hits.
PF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PRINTSiPR00368. FADPNR.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiDHNA_HAEIN
AccessioniPrimary (citable) accession number: P44856
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 7, 2015
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.