ID   SECB_HAEIN              Reviewed;         169 AA.
AC   P44853;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   27-MAR-2024, entry version 132.
DE   RecName: Full=Protein-export protein SecB;
GN   Name=secB; OrderedLocusNames=HI_0743;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).
RX   PubMed=11101901; DOI=10.1038/82040;
RA   Xu Z., Knafels J.D., Yoshino K.;
RT   "Crystal structure of the bacterial protein export chaperone secB.";
RL   Nat. Struct. Biol. 7:1172-1177(2000).
CC   -!- FUNCTION: One of the proteins required for the normal export of
CC       preproteins out of the cell cytoplasm. It is a molecular chaperone that
CC       binds to a subset of precursor proteins, maintaining them in a
CC       translocation-competent state. It also specifically binds to its
CC       receptor SecA.
CC   -!- SUBUNIT: Homotetramer, a dimer of dimers. One homotetramer interacts
CC       with 1 SecA dimer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the SecB family. {ECO:0000305}.
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DR   EMBL; L42023; AAC22401.1; -; Genomic_DNA.
DR   PIR; I64089; I64089.
DR   RefSeq; NP_438902.1; NC_000907.1.
DR   PDB; 1FX3; X-ray; 2.50 A; A/B/C/D=1-169.
DR   PDB; 1OZB; X-ray; 2.80 A; A/B/C/D/E/F/G/H=1-169.
DR   PDBsum; 1FX3; -.
DR   PDBsum; 1OZB; -.
DR   AlphaFoldDB; P44853; -.
DR   SMR; P44853; -.
DR   IntAct; P44853; 1.
DR   STRING; 71421.HI_0743; -.
DR   EnsemblBacteria; AAC22401; AAC22401; HI_0743.
DR   KEGG; hin:HI_0743; -.
DR   PATRIC; fig|71421.8.peg.779; -.
DR   eggNOG; COG1952; Bacteria.
DR   HOGENOM; CLU_111574_1_0_6; -.
DR   OrthoDB; 9795145at2; -.
DR   PhylomeDB; P44853; -.
DR   BioCyc; HINF71421:G1GJ1-781-MONOMER; -.
DR   EvolutionaryTrace; P44853; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   GO; GO:0006457; P:protein folding; IEA:UniProtKB-UniRule.
DR   GO; GO:0051262; P:protein tetramerization; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-UniRule.
DR   CDD; cd00557; Translocase_SecB; 1.
DR   Gene3D; 3.10.420.10; SecB-like; 1.
DR   HAMAP; MF_00821; SecB; 1.
DR   InterPro; IPR003708; SecB.
DR   InterPro; IPR035958; SecB-like_sf.
DR   NCBIfam; TIGR00809; secB; 1.
DR   PANTHER; PTHR36918; -; 1.
DR   PANTHER; PTHR36918:SF1; PROTEIN-EXPORT PROTEIN SECB; 1.
DR   Pfam; PF02556; SecB; 1.
DR   PRINTS; PR01594; SECBCHAPRONE.
DR   SUPFAM; SSF54611; SecB-like; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Chaperone; Cytoplasm; Protein transport; Reference proteome;
KW   Translocation; Transport.
FT   CHAIN           1..169
FT                   /note="Protein-export protein SecB"
FT                   /id="PRO_0000055378"
FT   STRAND          17..31
FT                   /evidence="ECO:0007829|PDB:1FX3"
FT   HELIX           35..38
FT                   /evidence="ECO:0007829|PDB:1FX3"
FT   STRAND          51..59
FT                   /evidence="ECO:0007829|PDB:1FX3"
FT   STRAND          62..71
FT                   /evidence="ECO:0007829|PDB:1FX3"
FT   TURN            76..78
FT                   /evidence="ECO:0007829|PDB:1FX3"
FT   STRAND          84..97
FT                   /evidence="ECO:0007829|PDB:1FX3"
FT   HELIX           100..108
FT                   /evidence="ECO:0007829|PDB:1FX3"
FT   HELIX           110..129
FT                   /evidence="ECO:0007829|PDB:1FX3"
FT   HELIX           142..156
FT                   /evidence="ECO:0007829|PDB:1FX3"
FT   HELIX           158..161
FT                   /evidence="ECO:0007829|PDB:1FX3"
SQ   SEQUENCE   169 AA;  19132 MW;  047DCC722965EC7B CRC64;
     MSEQKQDVAA TEEQQPVLQI QRIYVKDVSF EAPNLPHIFQ QEWKPKLGFD LSTETTQVGD
     DLYEVVLNIS VETTLEDSGD VAFICEVKQA GVFTISGLED VQMAHCLTSQ CPNMLFPYAR
     ELVSNLVNRG TFPALNLSPV NFDALFVEYM NRQQAENAEE KSEEEQTKH
//