Reviewed, UniProtKB/Swiss-Prot P44853 (SECB_HAEIN)

Names and origin

Protein names

Recommended name:
    Protein-export protein secB

Gene names

Name:	secB
Ordered Locus Names:	HI0743

Organism

Haemophilus influenzae [Complete proteome] [HAMAP]

Taxonomic identifier

727 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	169 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor secA. HAMAP MF_00821
Subunit structure	Homotetramer, a dimer of dimers. One homotetramer interacts with 1 secA dimer. HAMAP MF_00821
Subcellular location	Cytoplasm. HAMAP MF_00821
Sequence similarities	Belongs to the secB family.

Ontologies

Keywords
Biological process	Protein transport Translocation Transport
Cellular component	Cytoplasm
Molecular function	Chaperone
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	protein folding Inferred from electronic annotation. Source: HAMAP protein tetramerization Inferred from electronic annotation. Source: InterPro protein transport Inferred from electronic annotation. Source: HAMAP transmembrane transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	unfolded protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 169

169

Protein-export protein secB HAMAP MF_00821

PRO_0000055378

Secondary structure

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169

Helix Strand Turn

Details...

Beta strand

17 – 31

15

Helix

35 – 38

4

Beta strand

51 – 59

9

Beta strand

62 – 71

10

Turn

76 – 78

3

Beta strand

84 – 97

14

Helix

100 – 108

9

Helix

110 – 129

20

Helix

142 – 156

15

Helix

158 – 161

4

Sequences

	Sequence		Length	Mass (Da)
	P44853-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 047DCC722965EC7B	FASTA	169	19,132
	10 20 30 40 50 60 MSEQKQDVAA TEEQQPVLQI QRIYVKDVSF EAPNLPHIFQ QEWKPKLGFD LSTETTQVGD 70 80 90 100 110 120 DLYEVVLNIS VETTLEDSGD VAFICEVKQA GVFTISGLED VQMAHCLTSQ CPNMLFPYAR 130 140 150 160 ELVSNLVNRG TFPALNLSPV NFDALFVEYM NRQQAENAEE KSEEEQTKH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
[2]	"Crystal structure of the bacterial protein export chaperone secB." Xu Z., Knafels J.D., Yoshino K. Nat. Struct. Biol. 7:1172-1177(2000) [PubMed: 11101901] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBLGenBankDDBJ

L42023 Genomic DNA. Translation: AAC22401.1.

PIR

I64089.

RefSeq

NP_438902.1.

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1FX3	X-ray	2.50	A/B/C/D	1-169	[»]
1OZB	X-ray	2.80	A/B/C/D/E/F/G/H	1-169	[»]

ModBase

Search...

Genome annotation databases

GeneID

949770.

GenomeReviews

Gene locus HI0743 in contig L42023_GR.

KEGG

hin:HI0743.

TIGR

HI0743.

Phylogenomic databases

HOGENOM

P44853.

OMA

NGGFPPL.

Enzyme and pathway databases

BioCyc

HINF71421:HI_0743-MON.

Family and domain databases

HAMAP

MF_00821.
[Tree]

InterPro

IPR003708. SecB.
[Graphical view]

Gene3D

G3DSA:3.10.420.10. SecB. 1 hit.

Pfam

PF02556. SecB. 1 hit.
[Graphical view]

PRINTS

PR01594. SECBCHAPRONE.

ProDom

PD021849. SecB. 1 hit.
[Graphical view] [Entries sharing at least one domain]

TIGRFAMs

TIGR00809. secB. 1 hit.

ProtoNet

Search...

Entry information

Entry name

SECB_HAEIN

Accession

Primary (citable) accession number: P44853

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	November 3, 2009
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)