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P44853

- SECB_HAEIN

UniProt

P44853 - SECB_HAEIN

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Protein

Protein-export protein SecB

Gene

secB

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA.

GO - Biological processi

  1. protein folding Source: UniProtKB-HAMAP
  2. protein tetramerization Source: InterPro
  3. protein transport Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Protein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-export protein SecB
Gene namesi
Name:secB
Ordered Locus Names:HI_0743
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 169169Protein-export protein SecBPRO_0000055378Add
BLAST

Interactioni

Subunit structurei

Homotetramer, a dimer of dimers. One homotetramer interacts with 1 SecA dimer.

Protein-protein interaction databases

IntActiP44853. 1 interaction.
STRINGi71421.HI0743.

Structurei

Secondary structure

1
169
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi17 – 3115Combined sources
Helixi35 – 384Combined sources
Beta strandi51 – 599Combined sources
Beta strandi62 – 7110Combined sources
Turni76 – 783Combined sources
Beta strandi84 – 9714Combined sources
Helixi100 – 1089Combined sources
Helixi110 – 12920Combined sources
Helixi142 – 15615Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FX3X-ray2.50A/B/C/D1-169[»]
1OZBX-ray2.80A/B/C/D/E/F/G/H1-169[»]
ProteinModelPortaliP44853.
SMRiP44853. Positions 15-163.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP44853.

Family & Domainsi

Sequence similaritiesi

Belongs to the SecB family.Curated

Phylogenomic databases

eggNOGiCOG1952.
KOiK03071.
OMAiGSFPQLN.
OrthoDBiEOG6DVJZZ.
PhylomeDBiP44853.

Family and domain databases

Gene3Di3.10.420.10. 1 hit.
HAMAPiMF_00821. SecB.
InterProiIPR003708. SecB.
[Graphical view]
PfamiPF02556. SecB. 1 hit.
[Graphical view]
PRINTSiPR01594. SECBCHAPRONE.
SUPFAMiSSF54611. SSF54611. 1 hit.
TIGRFAMsiTIGR00809. secB. 1 hit.

Sequencei

Sequence statusi: Complete.

P44853-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSEQKQDVAA TEEQQPVLQI QRIYVKDVSF EAPNLPHIFQ QEWKPKLGFD
60 70 80 90 100
LSTETTQVGD DLYEVVLNIS VETTLEDSGD VAFICEVKQA GVFTISGLED
110 120 130 140 150
VQMAHCLTSQ CPNMLFPYAR ELVSNLVNRG TFPALNLSPV NFDALFVEYM
160
NRQQAENAEE KSEEEQTKH
Length:169
Mass (Da):19,132
Last modified:November 1, 1995 - v1
Checksum:i047DCC722965EC7B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22401.1.
PIRiI64089.
RefSeqiNP_438902.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22401; AAC22401; HI_0743.
GeneIDi949770.
KEGGihin:HI0743.
PATRICi20190127. VBIHaeInf48452_0779.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22401.1 .
PIRi I64089.
RefSeqi NP_438902.1. NC_000907.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1FX3 X-ray 2.50 A/B/C/D 1-169 [» ]
1OZB X-ray 2.80 A/B/C/D/E/F/G/H 1-169 [» ]
ProteinModelPortali P44853.
SMRi P44853. Positions 15-163.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P44853. 1 interaction.
STRINGi 71421.HI0743.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC22401 ; AAC22401 ; HI_0743 .
GeneIDi 949770.
KEGGi hin:HI0743.
PATRICi 20190127. VBIHaeInf48452_0779.

Phylogenomic databases

eggNOGi COG1952.
KOi K03071.
OMAi GSFPQLN.
OrthoDBi EOG6DVJZZ.
PhylomeDBi P44853.

Miscellaneous databases

EvolutionaryTracei P44853.

Family and domain databases

Gene3Di 3.10.420.10. 1 hit.
HAMAPi MF_00821. SecB.
InterProi IPR003708. SecB.
[Graphical view ]
Pfami PF02556. SecB. 1 hit.
[Graphical view ]
PRINTSi PR01594. SECBCHAPRONE.
SUPFAMi SSF54611. SSF54611. 1 hit.
TIGRFAMsi TIGR00809. secB. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
  2. "Crystal structure of the bacterial protein export chaperone secB."
    Xu Z., Knafels J.D., Yoshino K.
    Nat. Struct. Biol. 7:1172-1177(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).

Entry informationi

Entry nameiSECB_HAEIN
AccessioniPrimary (citable) accession number: P44853
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 26, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3