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P44853

- SECB_HAEIN

UniProt

P44853 - SECB_HAEIN

Protein

Protein-export protein SecB

Gene

secB

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA.

    GO - Biological processi

    1. protein folding Source: UniProtKB-HAMAP
    2. protein tetramerization Source: InterPro
    3. protein transport Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Chaperone

    Keywords - Biological processi

    Protein transport, Translocation, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein-export protein SecB
    Gene namesi
    Name:secB
    Ordered Locus Names:HI_0743
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 169169Protein-export protein SecBPRO_0000055378Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer, a dimer of dimers. One homotetramer interacts with 1 SecA dimer.

    Protein-protein interaction databases

    IntActiP44853. 1 interaction.
    STRINGi71421.HI0743.

    Structurei

    Secondary structure

    1
    169
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi17 – 3115
    Helixi35 – 384
    Beta strandi51 – 599
    Beta strandi62 – 7110
    Turni76 – 783
    Beta strandi84 – 9714
    Helixi100 – 1089
    Helixi110 – 12920
    Helixi142 – 15615

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1FX3X-ray2.50A/B/C/D1-169[»]
    1OZBX-ray2.80A/B/C/D/E/F/G/H1-169[»]
    ProteinModelPortaliP44853.
    SMRiP44853. Positions 15-163.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP44853.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SecB family.Curated

    Phylogenomic databases

    eggNOGiCOG1952.
    KOiK03071.
    OMAiGSFPQLN.
    OrthoDBiEOG6DVJZZ.
    PhylomeDBiP44853.

    Family and domain databases

    Gene3Di3.10.420.10. 1 hit.
    HAMAPiMF_00821. SecB.
    InterProiIPR003708. SecB.
    [Graphical view]
    PfamiPF02556. SecB. 1 hit.
    [Graphical view]
    PRINTSiPR01594. SECBCHAPRONE.
    SUPFAMiSSF54611. SSF54611. 1 hit.
    TIGRFAMsiTIGR00809. secB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P44853-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEQKQDVAA TEEQQPVLQI QRIYVKDVSF EAPNLPHIFQ QEWKPKLGFD    50
    LSTETTQVGD DLYEVVLNIS VETTLEDSGD VAFICEVKQA GVFTISGLED 100
    VQMAHCLTSQ CPNMLFPYAR ELVSNLVNRG TFPALNLSPV NFDALFVEYM 150
    NRQQAENAEE KSEEEQTKH 169
    Length:169
    Mass (Da):19,132
    Last modified:November 1, 1995 - v1
    Checksum:i047DCC722965EC7B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22401.1.
    PIRiI64089.
    RefSeqiNP_438902.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC22401; AAC22401; HI_0743.
    GeneIDi949770.
    KEGGihin:HI0743.
    PATRICi20190127. VBIHaeInf48452_0779.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22401.1 .
    PIRi I64089.
    RefSeqi NP_438902.1. NC_000907.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1FX3 X-ray 2.50 A/B/C/D 1-169 [» ]
    1OZB X-ray 2.80 A/B/C/D/E/F/G/H 1-169 [» ]
    ProteinModelPortali P44853.
    SMRi P44853. Positions 15-163.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P44853. 1 interaction.
    STRINGi 71421.HI0743.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC22401 ; AAC22401 ; HI_0743 .
    GeneIDi 949770.
    KEGGi hin:HI0743.
    PATRICi 20190127. VBIHaeInf48452_0779.

    Phylogenomic databases

    eggNOGi COG1952.
    KOi K03071.
    OMAi GSFPQLN.
    OrthoDBi EOG6DVJZZ.
    PhylomeDBi P44853.

    Miscellaneous databases

    EvolutionaryTracei P44853.

    Family and domain databases

    Gene3Di 3.10.420.10. 1 hit.
    HAMAPi MF_00821. SecB.
    InterProi IPR003708. SecB.
    [Graphical view ]
    Pfami PF02556. SecB. 1 hit.
    [Graphical view ]
    PRINTSi PR01594. SECBCHAPRONE.
    SUPFAMi SSF54611. SSF54611. 1 hit.
    TIGRFAMsi TIGR00809. secB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
    2. "Crystal structure of the bacterial protein export chaperone secB."
      Xu Z., Knafels J.D., Yoshino K.
      Nat. Struct. Biol. 7:1172-1177(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).

    Entry informationi

    Entry nameiSECB_HAEIN
    AccessioniPrimary (citable) accession number: P44853
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3